Navigation Links
The dangerous legacy of lead

Although lead is a well-known human health hazard, researchers at the University of Rochester Medical Center have discovered a new aspect of how it may work in mice to harm the function of T-cells, which regulate the body's immune response to bacteria, viruses and other bugs.

The discovery adds insight to the latest trend in lead research, as scientists shift their emphasis from the immediate public health threat to understanding the long-term burden on the body, said Michael McCabe Jr., Ph.D., associate professor of Environmental Medicine at the University of Rochester.

"We know more about lead than any other environmental agent, but we're still trying to understand exactly why lead is dangerous and what its legacy might be," said McCabe, who co-authored a recent study published in Toxicology and Applied Pharmacology.

Our research shows there may be additional long-term health threats," McCabe said. "Lead appears to disrupt the immune system's checks and balances, which must be in place if we are to successfully fight off pathogens. Our continuing research is aimed at discovering how lead upsets the balance of cells charged with protecting us."

Graduate student David G. Farrer, of the Department of Environment Medicine, who established that T cell function was targeted by lead, performed the laboratory work. Farrer also has shown that another crucial immune system cell ?myeloid suppressor cells, which control runaway immune responses ?may also be disrupted by lead exposure in mice.

The next step is to understand how this applies to humans. Already, scientists know that lead is toxic to the nervous system and certain regions of the brain. This latest research underscores the burden lead may pose to many organ systems, McCabe said. The National Institutes of Health is funding the research.

An estimated 434,000 children in the United States under age 5 have lead levels in their blood that are higher than the limit set by the Centers for Disease Control. Toxic exposure usually occurs in older housing, where children come in contact with lead paint and dust and, as a result, may experience intellectual impairment, behavioral problems and lifelong health issues. The effects of lead in children are irreversible, so public health officials are primarily focused on preventing these exposures.


'"/>

Source:University of Rochester Medical Center


Related biology news :

1. Too much water may be as dangerous as too little during long-distance athletic events
2. Colorful bacteria more dangerous
3. Study identifies substances in grapefruit juice that interact dangerously with some drugs
4. Commercial fishing causes dangerous fluctuations in fish populations
5. Newly discovered behavior in cancer cells signals dangerous metastasis
6. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... YORK , Feb. 2, 2016 ... of that Rising Market Are you interested ... analysis forecasts revenues for checkpoint inhibitors. Visiongain,s report ... market, submarket, product and national level. Avoid ... discover what progress, opportunities and revenues those emerging ...
(Date:2/2/2016)... RESTON, Va. , Feb. 2, 2016 /PRNewswire/ ... contract award from the U.S. Army Research Office ... extend the range and sensitivity of the company,s ... DoD,s Past Accounting Mission and, more generally, defense-related ... its DNA phenotyping capabilities (predicting appearance and ancestry ...
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Florida , February 11, 2016 ... and Promote Genetic Understanding to Support Research and Discovery ... GenomeAsia 100K, today announced an ambitious plan to sequence 100,000 ... South Asian countries and at least 7 of North and ... In the first phase, the project will focus on ...
(Date:2/11/2016)... -- Vermillion, Inc. (NASDAQ: VRML ), a bio-analytical solutions ... of the Steering Committee for its Pelvic Mass Registry. ... Pelvic masses can present physicians and healthcare professionals with ... ruled out, pelvic masses may include cancers of the ... tumors and gastrointestinal and urinary tract masses. ...
(Date:2/11/2016)... , Feb. 11, 2016  Bioethics International, a not-for-profit organization ... researched, developed, marketed and made accessible to patients around the ... had named the publication of the Good Pharma ... publication is also featured as one of BMJ Open ... last year that are most frequently read. Ed ...
(Date:2/11/2016)...  Wellcentive today announced it has been selected ... -based community care organization (CCO) with more than ... reporting and care management solutions and services. Wellcentive,s ... quality managers, analysts and care managers while providing ... FamilyCare members. Oregon ...
Breaking Biology Technology: