Navigation Links
The closest look ever at the cell's machines

y of prefabricating core elements of machines and then synthesizing additional, snap-on molecules that give each machine a precise function. That provides an economic way to diversify biological processes and also to control them."

Thus if the cell needs to respond quickly, such as in a disease or another emergency, it may only need to produce few parts to switch on or tune the machine. On the other hand, if something shouldn't happen, it may only need to block the production of a few molecules.

Patrick Aloy and Rob Russell at EMBL used sophisticated computer techniques to reveal the modular organisation of these cellular machines. "This is the most complete set of protein complexes available and probably the set with the highest quality," Aloy says. "Most proteomics studies in the past have shown whether molecules interact or not, in a 'yes/no' way. The completeness of this data lets us see how likely any particular molecule is to bind to another. By combining such measurements for all the proteins in the cell, we discovered new complexes and revealed their modular nature."

"Investigating protein complexes has always posed a tricky problem ?they're too small to be studied by microscopes, and generally too large to be studied by techniques like X-ray crystallography," says Russell. "But they play such a crucial role in the cell that we need to fill in this gap. There's still a huge amount to be learned from this data and from the methods we are developing to combine computational and biochemical investigations of the cell."

"This is an important milestone towards a more global and systems-wide understanding of the cells of organisms ranging from yeast to humans," says Peer Bork, Head of the Structural and Computational Biology Unit at EMBL, and one of the authors of the paper. "Ultimately we hope to achieve a 'molecular anatomy' that takes us from the level of the entire cell to the much deeper level of all the molecules and atoms th
'"/>

Source:European Molecular Biology Laboratory


Page: 1 2 3

Related biology news :

1. Study shows how retinoic acid enters a cells nucleus
2. Hopkins researchers discover genetic switch that turns off an oxygen-poor cells combustion engine
3. Johns hopkins researchers find link between cells energy use and genome health
4. Columbia scientists determine 3-dimensional structure of cells fuel gauge
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The closest look ever the cell machines

(Date:6/25/2015)... According to a new ... Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive & ... Others) & Geography - Global Forecast to 2014 ... is expected to reach $14,500.07 Million by 2020, ... Browse 76 market Tables and 109 Figures spread ...
(Date:6/24/2015)... 24, 2015 The biologics safety testing market ... for the market include growth of the pharmaceutical and ... launches. Over the years, the number of drug approvals ... 2010, the FDA approved 225 drug applications and Health ... Europe accounted for 3,822 of the ...
(Date:6/24/2015)... DUBLIN , June 22, 2015 ... has announced the addition of the "Huawei ... Analysis" report to their offering. ... going to the opposite direction than Apple,s and ... innovative fingerprint sensor developed by Fingerprint Cards, a ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... and Research Center report in the March issue of ... as fibulins 3 and 5, slow the growth of ... sprouting. The proteins are promising candidates for use in ... which regulate cell proliferation, migration and invasion. In the ...
... imaging study shows that age-related breakdown of myelin, the ... with the presence of a key genetic risk factor ... the January edition of the peer-reviewed journal Archives of ... evidence that myelin breakdown is a key contributor to ...
... home, but the presence of gas stresses out plants too. ... University of Nottingham have found that changes in the physical ... leaks in natural gas pipelines. "Our study was about ... leaks via the spectrum of reflected light from plants, which ...
Cached Biology News:Proteins stop blood-vessel and tumor growth in mice 2Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown 2Plants used to detect gas leaks, from outer space! 2
(Date:7/30/2015)... , July 30, 2015   GenoSpace ... for the interpretation and analysis of genomic and ... Fischer has joined the company as Vice ... - http://photos.prnewswire.com/prnh/20150730/250931 "GenoSpace ... to integrate, interpret, analyze and explore complex sets ...
(Date:7/30/2015)... CITY, Kan. , July 30, 2015 /PRNewswire/ ... ), a pet therapeutics company focused on the ... for companion animals, today announced that its strategic ... from a dose confirmation study of AT-016, an ... Aratana for the treatment of osteoarthritis pain in ...
(Date:7/30/2015)... July 30, 2015  Discovery Laboratories, Inc. (Nasdaq: ... received the second $1.0M tranche under a previously ... grant valued at up to $3.0 million to ... surfactant as a potential medical countermeasure to mitigate ... was awarded an initial $1.0 million under this ...
(Date:7/29/2015)... 30, 2015 According to a new ... Trends & Forecasts (2015-2020), , published by Mordor Intelligence, the ... by the end of 2020, with North America ... than 40% of the global market size. The Global market ... of 13.7% during the period of (2015-2020).      ...
Breaking Biology Technology:GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3
... week from his position as director of the nonpartisan ... on the reasons for his ouster. , ,And while ... results of an audit of the bureaus performance as ... Speaker John Gard (R-Peshtigo) said the move was simple ...
... WI. - A business Internet Service Provider (ISP) in ... getting ready to launch a virus protection service ... FirstBridge, McAfee and Postini. , , Cyberlynk Network Inc. ... to add virus protection to the service offering in ...
... , ,MADISON-WI. - The Wisconsin Technology Network recently ... researcher about his work in games and education, and ... used in academics. , ,Kurt Squire, Ph.D., was ... his research on games and learning. A former elementary ...
Cached Biology Technology:Wahl Mute on Firing from Legislative IT Bureau -- but politics could be to blame 2Franklin Firm to Pick Fight with Postini? 2Franklin Firm to Pick Fight with Postini? 3Franklin Firm to Pick Fight with Postini? 4GameBased Learning Strategies 2GameBased Learning Strategies 3
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
... Rabbit polyclonal antibody to human XAB2 (amino ... first identified through its interaction with XPA. ... fraction of XAB2 interacts with the transcription-coupled ... as with RNA polymerase II. Microinjection experiments ...
... coating using advanced automated high throughput microplate processing equipment that ... also accommodate virtually any lot size of the following formats ... 8 and 12 well strips, ... 384 well microplate, ...
...
Biology Products: