Navigation Links
The closest look ever at the cell's machines

Today researchers in Germany announce they have finished the first complete analysis of the "molecular machines" in one of biology's most important model organisms: S. cerevisiae (baker's yeast). The study from the biotechnology company Cellzome, in collaboration with the European Molecular Biology Laboratory (EMBL), appears in this week's online edition of Nature.

"To carry out their tasks, most proteins work in dynamic complexes that may contain dozens of molecules," says Giulio Superti-Furga, who launched the large-scale project at Cellzome four years ago. "If you think of the cell as a factory floor, up to now, we've known some of the components of a fraction of the machines. That has seriously limited what we know about how cells work. This study gives us a nearly complete parts list of all the machines, and it goes beyond that to tell us how they populate the cell and partition tasks among themselves."

The study combined a method of extracting complete protein complexes from cells (tandem affinity purification, developed in 2001 by Bertrand Séraphin at EMBL), mass spectrometry and bioinformatics to investigate the entire protein household of yeast, turning up 257 machines that had never been observed. It also revealed new components of nearly every complex already known.

In the course of the work, new computational techniques were developed at EMBL that gave new insights into the dynamic nature of protein complexes. In contrast to most man-made factories, cells continually dismantle and reassemble their machines at different stages of the cell cycle and in response to environmental challenges, such as infections.

"This would be a logistical nightmare if the cell had to build every machine from scratch any time it needed to do something," says Anne-Claude Gavin, former Director of Molecular and Cell Biology at Cellzome and currently a team leader at EMBL. "We've discovered that the reality is different. Cells use a mixed strateg
'"/>

Source:European Molecular Biology Laboratory


Page: 1 2 3

Related biology news :

1. Study shows how retinoic acid enters a cells nucleus
2. Hopkins researchers discover genetic switch that turns off an oxygen-poor cells combustion engine
3. Johns hopkins researchers find link between cells energy use and genome health
4. Columbia scientists determine 3-dimensional structure of cells fuel gauge
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The closest look ever the cell machines

(Date:4/21/2015)... 2015 High crime rate, ... boosting access control systems market in Saudi ... recently published report by TechSci Research " Saudi Arabia Access ... control systems market in Saudi Arabia ... access control systems market in the Kingdom is growing ...
(Date:4/17/2015)... 2015 Increasing adoption ... advancement to drive biometric systems market in ... According to a recently released TechSci ... ", biometric systems market in Saudi ... at CAGR of over 22% through 2020. The ...
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... from the ARC Centre of Excellence for Coral Reef ... science to help solve some of the world,s biggest ... science fellow at the ARC CoECRS, holds a joint ... University in the USA. Dr Hicks says more ...
... WEST LAFAYETTE, Ind. Researchers have discovered a tube-shaped structure ... deliver its DNA during the infection process and then dissolves ... mechanism in the phiX174 virus, which attacks E. coli ... bacteria, is in a class of viruses that do not ...
... by scientists could help combat the spread of sleeping sickness. ... to communicate with one another could help limit the spread of ... could be designed to disrupt the flow of messages sent between ... disrupts sleep patterns is transmitted by the bite of the ...
Cached Biology News:Linking social science and ecology to solve the world's environmental problems 2Virus grows tube to insert DNA during infection then sheds it 2
(Date:5/26/2015)... 26, 2015 WORMS, GERMANY – ... Co. (NYSE: GRA) announces that its manufacturing facility ... (GMP) certification from EXCiPACT™, an independent organization that ... , All three Grace facilities that ... excipient silica gels have now received GMP certification, ...
(Date:5/26/2015)... , Kalifornien und HILDEN, Deutschland, May ... QIAGEN Clinical Insight ® ... Genvarianten und die Erstellung dazugehöriger Berichte; Vorstellung ...     QIAGEN N.V. (NASDAQ: ... heute die Markteinführung von QIAGEN Clinical Insight ...
(Date:5/26/2015)... 2015  Sangamo BioSciences, Inc. (NASDAQ: SGMO ) announced ... will provide an update on the progress of Sangamo,s ZFP ... company,s business strategy at 1:30pm ET on Monday, June 1, ... is being held in New York, NY ... may be accessed via a link on the Sangamo BioSciences ...
(Date:5/26/2015)... , May 26, 2015  Alere Inc. (NYSE: ALR ... its failure to timely file its Quarterly Report on Form ... "Form 10-Q"), it has received a notice from the New ... in compliance with the NYSE,s continued listing requirements under the ... Listed Company Manual. The reason for the ...
Breaking Biology Technology:CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 2QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 3QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 4QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 5QIAGEN bringt klinische Bioinformatik-Plattform für Next Generation Sequencing-Anwendungen auf den Markt 6Sangamo BioSciences Announces Presentation At The Jefferies 2015 Global Healthcare Conference 2
... , NEW HAVEN, Conn., Sept. ... discovery, development and commercialization of novel drugs for the treatment ... been appointed to the Company,s Board of Directors, succeeding Joseph ... Zook is President of MedImmune, Chief Executive Officer of AstraZeneca ...
... , CHENGDU, China, Sept. ... TPI ), a manufacturer and supplier ... its new,production facility obtained the Good Manufacturing Practices ... Food and Drug,Administration ("SFDA") in China. , ...
... VIENNA, Va., Sept. 16 CEL-SCI Corporation ... and therapeutics for the prevention and treatment of infectious diseases ... Food and Drug Administration (FDA) has indicated that the Company ... effect of its investigational LEAPS-H1N1 treatment on the white blood ...
Cached Biology Technology:Rib-X Pharmaceuticals, Inc. Appoints Tony Zook of MedImmune to Board of Directors 2Rib-X Pharmaceuticals, Inc. Appoints Tony Zook of MedImmune to Board of Directors 3Tianyin Pharmaceutical Co., Inc. Obtains GMP Certification for Its New Production Facility 2Tianyin Pharmaceutical Co., Inc. Obtains GMP Certification for Its New Production Facility 3CEL-SCI to Commence First Clinical Study with Hospitalized H1N1 Infected Patients 2CEL-SCI to Commence First Clinical Study with Hospitalized H1N1 Infected Patients 3CEL-SCI to Commence First Clinical Study with Hospitalized H1N1 Infected Patients 4
Guanine nucleotide-binding protein G(k), alpha subunit...
Goat anti-VAV2 Class: Antibody Product Group: Miscellaneous Antibody...
... P7 D7 F5] to RYK ( ... Antigen: Synthetic ... to amino acids 462 - 475 ... Gene ID: 6259 ...
DAP12 Market Segment: Protein Kinases...
Biology Products: