Navigation Links
The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures

The Protein Structure Initiative (PSI), a national program aimed at determining the three-dimensional shapes of a wide range of proteins, has now determined more than 1,000 different structures. These structures will shed light on how proteins function in many life processes and could lead to targets for the development of new medicines.

The PSI is a 10-year, approximately $600 million project funded largely by the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health. The first half of this project ?a pilot phase that started in 2000 ?has centered on developing new tools and processes that enable researchers to quickly, cheaply, and reliably determine the shapes of many proteins found in nature.

“One thousand protein structures is a significant milestone for the PSI, and it shows an impressive return on the investment in the technology and methods for rapid structure determination,?said Jeremy M. Berg, Ph.D., director of NIGMS. “These structures are interesting in their own right and provide the basis for modeling many important proteins.?/p>

Some of the newly determined structures are of proteins found in plants, mice, yeast, and bacteria, including the pathogenic types that cause pneumonia, anthrax, and tuberculosis.

The nine PSI pilot centers have transformed protein structure determination from a mostly manual process to a highly automated one. Robotic instruments rapidly clone, express, purify, crystallize, and analyze many proteins simultaneously, cutting the time it takes to determine a single protein structure from months to days. For example, a robotic arm drops protein solution into thousands of tiny wells for crystallization trials, and an imaging system quickly scans the wells looking for signs of crystal formation ?key to capturing protein structures.

“At this large scale, it would be unthinkable to do all these steps by hand,?said John Norvell, Ph.D., director of the PSI at
'"/>

Source:NIH/National Institute Of General Medical Sciences


Page: 1 2 3

Related biology news :

1. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
2. Whole genome promoter mapping - Human Genome Project v2.0?
3. Knockout Mouse Project
4. Research on Worms Yields Clues on Aging
5. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
6. A step toward the $1,000 personal genome using readily available lab equipment
7. Students discover 11,000 year old remains of Irish Elk
8. Boston University biomedical engineers win major grant for pursuit of the $1,000 Genome
9. Scientists win grants to develop $1,000 genome sequencing technology
10. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
11. Protein discovery could unlock the secret to better TB treatment
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The Shapes Life NIGMS Project Yields More Than Protein Structures

(Date:5/17/2013)... The State University of New Jersey, and City University ... called Visikol TM that effectively clears organisms to ... place of chloral hydrate, which is one of the ... tightly regulated by the Drug Enforcement Administration (DEA) due ... or clearing agents, are vital for viewing organisms under ...
(Date:5/17/2013)... project (Intelligent Cargo in Efficient and Sustainable Global Logistics ... an improvement in the efficiency of intermodal loading systems ... making. It comprises 29 European organisations with experience in ... has a budget totalling 17,000,000 and a duration of ... to specify and develop the semantic components and ontologies ...
(Date:5/16/2013)... Bethesda, MD (May 17, 2013) Illustrating a ... the American Gastroenterological Association (AGA) Research Foundation ... Future Student Research Fellowship Award recipients. Supported by ... Kidney Diseases (NIDDK), this new award helps underrepresented ... digestive disease and nutrition research. , "By establishing ...
Breaking Biology News(10 mins):New formula invented for microscope viewing, substitutes for federally controlled drug 2New formula invented for microscope viewing, substitutes for federally controlled drug 3New logistics services that will cut energy consumption and CO2 emissions 2Underrepresented minority students receive fellowships in digestive disease and nutrition research 2
... often get bad press, with those found in water ... The University of Nottingham are using these tiny organisms ... and refine water cleaning technology. These one-celled organisms ... is being treated prior to industrial use or even ...
... Think of bacteria eating rock. Now think of bacteria ... on bacteria in that rock 15,000 feet underwater" ... Betty Moore Foundation, USC researcher Katrina Edwards will lead ... Recently discovered subseafloor microbes, which live on chemical ...
... being launched today to tackle some of the most ... which can devastate crop yields across the developing world. ... live in rural areas and most depend on agriculture ... through higher incomes, more and cheaper food, and more ...
Cached Biology News:Bacteria and nanofilters -- the future of clean water technology 2USC awarded $3.9M for lab under the sea 2Major scientific push to tackle agricultural productivity and food security in developing world 2Major scientific push to tackle agricultural productivity and food security in developing world 3
(Date:5/17/2013)...  Insero Health, Inc., a company developing natural compounds ... neurological disorders, is today reporting top-line results from a ... patients with drug-resistant epilepsy.  The data are being presented ... meeting by Dr. Steven Schachter , ... Advisory Board.  In this study, INS001 appeared safe and ...
(Date:5/17/2013)... 17, 2013 RURO Inc. is ... 4.1, a versatile refinement to the smart management ... improves its advanced methodical management for transgenic animal ... 4.1. The network-based platform provides user access with ... While continuing to emphasize streamlined tasks, such as ...
(Date:5/17/2013)... (PRWEB) May 17, 2013 Tooth decay is ... showing active signs of the disease. The World Health Organization ... nearly 100% of adults have cavities. What are the long-term ... is showing a strong connection between the oral bacterial imbalance ... this disease so rampant, yet it is also 100% preventable? ...
(Date:5/16/2013)... Oven Industries, Inc. has been an industry ... sensors since 1964. Expertly designed, the proportional-integral-derivative PID ... applications. As one of the most commonly ... loop feedback system, which helps minimize errors. With three-term ... systematic process, using a control element, like a valve ...
Breaking Biology Technology:Insero Health Reports Positive Data on Phase I Trial of Novel Therapy for Drug-resistant Epilepsy 2RURO Introduces ezColony 4.1 – The Versatile Transgenic Animal Colony Management Software 2Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 2Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 3New PID Temperature Controllers Announced by Oven Industries Inc. 2
... (Infectious Disease Research,Institute) and Immune Design Corp. announced ... to which Immune Design Corp. is granted a ... of,IDRI,s Glycopyranosyl Lipid Adjuvant (GLA) technology for products ... to fight infectious diseases of,the developing world, IDRI ...
... WWMR, Inc., the marketing research,leader in pain, ... Pain,Drug Company Survey". The top three most ... according to the 100 pain clinic,physicians surveyed in ... for,their knowledgeable, respectful and informed sales representatives, their,sampling/voucher ...
... 20 A US District Court,judge in Oregon yesterday ... & Nephew,s (NYSE: SNN ; LSE: SN) ... of Naples, Fla., from manufacturing or,selling medical devices that ... Dr. John O. Hayhurst of Portland, Ore. The ...
Cached Biology Technology:IDRI and Immune Design Corp. Enter License Agreement on GLA Vaccine Adjuvant 2WWMR Announces Pain Clinic Physicians' Most Appreciated Companies: Pfizer, Eli Lilly and Endo Pharmaceuticals 2WWMR Announces Pain Clinic Physicians' Most Appreciated Companies: Pfizer, Eli Lilly and Endo Pharmaceuticals 3US District Court Enters Final Judgment in Favor of Smith & Nephew; Permanent Injunction Prohibits Arthrex Inc. From Selling Infringing Medical Devices 2US District Court Enters Final Judgment in Favor of Smith & Nephew; Permanent Injunction Prohibits Arthrex Inc. From Selling Infringing Medical Devices 3
BD BioCoat Collagen I 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of rat tail collagen type I....
Topoisomerase II...
... a positive selection for creating baculovirus recombinants ... insect cells. The kit improves on the ... eliminating the time-consuming steps of plaque purification. ... with a portion of the essential open ...
... The CHEMICON XpressPack™ Colorimetric Detection System ... detection of amplified DNA generated by an ... of a selected target of interest. ... Colorimetric Detection System is a hybridization capture ...
Biology Products: