Navigation Links
The Bacteria's guide to survival

If there was a market for it, a survival guide for bacteria might include topics like "How to use your pili to keep your host from going apoptotic." A host's cells can respond to a bacterial infection with apoptosis, or programmed cell death. For bacteria that pass directly from host to host, this can pose a problem. If the bacteria are highly virulent and induce too much cell death, they could take down their host before they're able to jump ship, thus hurting the bacteria's chances of survival in the long run.

Reporting in the open-access journal PLoS Biology, Magdalene So and colleagues present evidence that bacteria can induce changes in hosts' gene expression - and possibly keep the host cells alive longer - through tiny tugs on cell membranes. The study examined gene activity in human epithelial cells infected with Neisseria gonorrhoeae, the bacteria responsible for the sexually transmitted disease gonorrhea.

By comparing cells infected with normal N. gonorrhoeae to those infected with a mutant strain with defective pili, the researchers found a subset of 52 host genes that had higher activity when the host was infected with the normal bacteria, suggesting that the pulls of the pili were responsible. They then showed that an artificial mechanical pull on the host cell membrane could trigger a signaling cascade in the host cells to affect the host's gene expression.

Many of the genes that increased in activity due to the tugs were already known to regulate apoptosis and cellular response to stress, including mechanical strain on the membrane. Also, a majority of these genes were known to be induced by a family of proteins called mitogen-activated protein kinases, or MAPKs. The researchers showed that blocking MAPKs reduced the activity of several of the genes that are usually enhanced by infection with the normal bacteria. Also, they found that cells infected with the bacteria tended to survive treatment with staurosporine, a chemical tha
'"/>

Source:PLoS Biology


Page: 1 2

Related biology news :

1. DNA: Bacterias survival ration
2. Researchers discover stem cell guide that may be key for targeting neural stem cell treatments
3. Ethical guidelines suggested for research that would put human stem cells in primates
4. Gradient guides nerve growth down spinal cord
5. Master regulatory gene found that guides fate of blood-producing stem cells
6. Light guides flight of migratory birds
7. 3-D ultrasound scanner could guide robotic surgeries
8. AIDS study challenges conventional treatment guidelines for HIV patients
9. Clues to gene expression in cystic fibrosis will guide research
10. AIDS vaccine research offers new insights on survival
11. Singing for survival
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The Bacteria guide survival

(Date:10/18/2014)... stress and stress-related psychiatric disorders are associated ... the molecular mechanisms underlying this relation are ... the development of targeted preventive strategies and ... diseases. This work is presented at the ... Now an international group of researchers from ...
(Date:10/17/2014)... news release is available in German . ... millions of sperms every day in order to reproduce? And ... are the topic of the latest issue of the research ... 2014). The evolutionary biologist Steven Ramm from Bielefeld University Bielefeld ... it is not unusual for a female to copulate with ...
(Date:10/16/2014)... William and Mary,s Virginia Institute of Marine Science ... Environmental Protection Agency to identify the streams and ... develop tools to help local governments and citizens ... critically on a dataset of tidal-marsh observations first ... with this historical baseline can today,s researchers accurately ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Sperm wars 2EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3
... use of an automated, underwater cell analyzer developed at ... managers were recently able to detect a bloom of ... prevent human consumption of tainted shellfish. Shellfish beds in ... though they are expected to re-open in the next ...
... This research work is the first step to confirm ... to detect the signs of the Climatic Change through the temperatures ... of Applied Physics of the University of Granada ... maximum and minimum temperature series of every month since the end ...
... FAIRBANKS, AlaskaDuring the mid-1970s, Glenn Shaw of the Geophysical ... the notion of Arctic haze after collecting aerosol samples ... Arctic to contain relatively pure air due to its ... rocked once Shaws data indicated there was a murky ...
Cached Biology News:Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas 2Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas 3Scientists compiled 20th century temperature data in Spain as evidence of climatic change 2Atmospheric scientists gear up for collaborative airborne campaigns 2
(Date:10/22/2014)... The North American crystal oscillator market report defines and ... forecast of revenue. This market was valued at $531.4 ... million by 2018, at a CAGR of 3.3% from ... the North American crystal oscillator market report, to get ... provides a glimpse of the segmentation of the market, ...
(Date:10/22/2014)... 22, 2014 Involution Studios , ... of a new infographic, Understanding Ebola . ... beautifully designed, easy to follow informative tool for anyone ... outbreak, symptoms and prevention. , "As the news has ... 2014 Ebola outbreak represents not only a healthcare crisis ...
(Date:10/22/2014)... Diego, CA (PRWEB) October 22, 2014 ... balances from Sartorius, A & D Weighing, Rice ... Sartorius CPA Semi-Micro Balance . The Sartorius CPA ... for an affordable high-quality, precise, and user-friendly laboratory ... manufacturing of laboratory equipment, their laboratory balances are ...
(Date:10/22/2014)... 2014 Physicians Choice Laboratory Services ... menu, which enables healthcare providers to individualize therapeutic ... evidence-based results, healthcare providers are better able to ... while minimizing risks for adverse drug reactions and ... the FDA [1] more than 2.2 million adverse ...
Breaking Biology Technology:The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3
Canine Serum...
NORMAL DONOR DONKEY SERUM...
Homo sapiens toll interacting protein Antigen: Recombinant Protein...
Mouse monoclonal [PRMT5-21] to PRMT5 ( Abpromise for all tested applications). entrezGeneID: 10419 SwissProtID: O14744...
Biology Products: