Navigation Links
The Bacteria's guide to survival

If there was a market for it, a survival guide for bacteria might include topics like "How to use your pili to keep your host from going apoptotic." A host's cells can respond to a bacterial infection with apoptosis, or programmed cell death. For bacteria that pass directly from host to host, this can pose a problem. If the bacteria are highly virulent and induce too much cell death, they could take down their host before they're able to jump ship, thus hurting the bacteria's chances of survival in the long run.

Reporting in the open-access journal PLoS Biology, Magdalene So and colleagues present evidence that bacteria can induce changes in hosts' gene expression - and possibly keep the host cells alive longer - through tiny tugs on cell membranes. The study examined gene activity in human epithelial cells infected with Neisseria gonorrhoeae, the bacteria responsible for the sexually transmitted disease gonorrhea.

By comparing cells infected with normal N. gonorrhoeae to those infected with a mutant strain with defective pili, the researchers found a subset of 52 host genes that had higher activity when the host was infected with the normal bacteria, suggesting that the pulls of the pili were responsible. They then showed that an artificial mechanical pull on the host cell membrane could trigger a signaling cascade in the host cells to affect the host's gene expression.

Many of the genes that increased in activity due to the tugs were already known to regulate apoptosis and cellular response to stress, including mechanical strain on the membrane. Also, a majority of these genes were known to be induced by a family of proteins called mitogen-activated protein kinases, or MAPKs. The researchers showed that blocking MAPKs reduced the activity of several of the genes that are usually enhanced by infection with the normal bacteria. Also, they found that cells infected with the bacteria tended to survive treatment with staurosporine, a chemical tha t normally induces apoptosis.

Overall, the group's findings support previous speculations that some bacteria influence gene expression and the fate of cells in their hosts by tugging on the host cells' membranes with their pili. For bacteria like N. gonorrhoeae that pass directly from host to host, the researchers argue, it would be in a bacterium's interest to help keep its host alive. And bacteria appear to do this with the help of their pili.

###

Citation: Howie HL, Glogauer M, So M (2005) The Neisseria gonorrhoeae type IV pilus stimulates mechanosensitive pathways and cytoprotection through a pilT-dependent mechanism. PLoS Biol 3(4): e100.


'"/>

Source:PLoS Biology


Related biology news :

1. DNA: Bacterias survival ration
2. Researchers discover stem cell guide that may be key for targeting neural stem cell treatments
3. Ethical guidelines suggested for research that would put human stem cells in primates
4. Gradient guides nerve growth down spinal cord
5. Master regulatory gene found that guides fate of blood-producing stem cells
6. Light guides flight of migratory birds
7. 3-D ultrasound scanner could guide robotic surgeries
8. AIDS study challenges conventional treatment guidelines for HIV patients
9. Clues to gene expression in cystic fibrosis will guide research
10. AIDS vaccine research offers new insights on survival
11. Singing for survival
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
Breaking Biology News(10 mins):
(Date:9/12/2017)... ... September 12, 2017 , ... ... announced the release of their latest product LabCODE™, a novel Lab Information ... LabCODE™ offers pre-built capabilities for Biobanking, Pharmacokinetics, Pharmacogenetics, Next Generation Sequencing, Flow ...
(Date:9/12/2017)... ... 2017 , ... VetStem Biopharma, Inc. , announced that a major new ... license to that patent. This patent covers methods for isolating stem ... stem cell with matrix materials, and incorporating the stem cells in an implant. ...
(Date:9/12/2017)... ... , ... An August 30th article on Daily Express explores a ... aging and overweight patients suffer from enlarged veins (genetics are also an important component), ... , The Washington State clinic Northwest Vein & Aesthetic Center notes that patients troubled ...
(Date:9/12/2017)... ... September 12, 2017 , ... OAI, ... semiconductor, MEMS, and microfluidics industries, announced today that multiple units of their advanced, ... design approach adds the flexibility required to meet the customers’ specific production process. ...
Breaking Biology Technology: