Tetanus toxin is a neurotoxin belonging to the same family as botulinum neurotoxins, which cause botulism. These have been successfully used as a therapy to treat disorders caused by abnormal muscular contractions such as strabismus, cerebral palsy, anal contractions and torticollis. Recently these toxins have been used even in cosmetics against wrinkles. For these therapeutic and cosmetic applications, the scientists are working with sublethal doses of toxins.
Led by José Aguilera, scientists from the Department of Biochemistry and Molecular Biology and the Institute of Neuroscience at the UAB, have studied whether it would also be possible to use sublethal doses of tetanus toxin and molecules derived from tetanus toxin for therapeutic purposes. The results have been obtained in the laboratory after 20 years of studying these toxins, and they are very encouraging.
Two separate, distinct parts form the tetanus toxin molecule: one part is the cause of the toxic effects and the tetanus symptoms; the other, however, is harmless and is able to penetrate and affect the nervous system. This harmless part, called the carboxy-terminal domain, has been reproduced in large quantities in the laboratory so that tests can be carried out on its effects on the nervous system of rats.
The experiments have shown that the harmless part inhibits serotonin from being transported through the synaptic membranes, i.e. the membranes that connect the neurones so that signals can be sent through the brain. The molecule is as effective as the selective inhibit
Source:Universitat Autonoma de Barcelona