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Testes to incubate stem cells

e tightly regulated, Sariola pointed out.

The Dutch researchers are also hunting for the ideal conditions and nutrients that will coax spermatogonial stem cells into becoming sperm. So far, they have found that growth factors GDNF and fibroblast growth factor (FGF) seem to be necessary to enhance cell growth. The team's next move is to transplant monkey and human cells into the mouse testes system.

"It is truly remarkable that mouse testes can sustain these bovine cells in culture," says Elaine Dzierzak, who coordinates a EuroSTELLS project at Erasmus University Medical Centre in Rotterdam. Testicular cultures could also prove an ideal system to test compounds that might affect sperm-production such as endocrine disruptors or therapeutic drugs.


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Source:European Science Foundation


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