Navigation Links
Testes to incubate stem cells

Men may cringe at the idea, but sperm-producing stem cells found in testicles could be extracted, grown in the lab, and frozen for future use. A team in the Netherlands has successfully harvested spermatogonial stem cells from cows and cultured them inside mouse testes. The hope is that the same thing could be done for men. "This is a very promising route to help young cancer patients undergoing chemotherapy," Dirk de Rooij of Utrecht University, Netherlands, told participants gathered at the first EuroSTELLS conference in Venice last month.

The research team were delighted to find abundant bovine spermatogonial stem cells thriving in the mouse testes, since they are hard to spotin tissue sections. Once the researchers learned to isolate these elusive sperm-producing cells from bull calfs, they transplanted them into mouse testes. Despite the foreign surroundings, the bovine cells survived for long periods, up to three months, although they failed to fully develop into sperm, said de Rooij.

"Our plan is to develop a culture system for spermatogonial stem cells" de Rooij told conference attendees. Although admitting the leap to humans is considerable, the colonised mouse testes are already providing useful insights.

"We'd like to know how to culture human spermatogenic stem cells to restore male fertility after cancer therapy," says Hannu Sariola, from the University of Helsinki in Finland who is also working towards a similar goal.

Bizarrely, a brain cell growth factor also has a powerful influence on spermatogonial stem cells. Glial cell derived neurotrophic factor (GDNF) is also involved in spermatogenesis: levels are high during the neonatal period and drop in adulthood. Indeed, mice that have been genetically manipulated to express high levels of GDNF in the testes produce huge clusters of spermatogonial stem cells. But the risk of cancer is boosted too, so it is not just about turning on the GDNF tap indiscriminately. It must b e tightly regulated, Sariola pointed out.

The Dutch researchers are also hunting for the ideal conditions and nutrients that will coax spermatogonial stem cells into becoming sperm. So far, they have found that growth factors GDNF and fibroblast growth factor (FGF) seem to be necessary to enhance cell growth. The team's next move is to transplant monkey and human cells into the mouse testes system.

"It is truly remarkable that mouse testes can sustain these bovine cells in culture," says Elaine Dzierzak, who coordinates a EuroSTELLS project at Erasmus University Medical Centre in Rotterdam. Testicular cultures could also prove an ideal system to test compounds that might affect sperm-production such as endocrine disruptors or therapeutic drugs.


'"/>

Source:European Science Foundation


Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Elusive HIV shape change revealed; Key clue to how virus infects cells
4. Scientists rid stem cell culture of key animal cells
5. Genetically modified natural killer immune cells attack, kill leukemia cells
6. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
7. Tiny scaffolding allows stem cells to become working fat cells
8. Researchers devise way to mass-produce embryonic stem cells
9. New insight into regulation of blood stem cells
10. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
11. Protein helps regulate the genes of embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
Breaking Biology Technology: