Navigation Links
Test reveals effectiveness of potential Huntington's disease drugs

A test using cultured cells provides an effective way to screen drugs against Huntington's disease and shows that two compounds ?memantine and riluzole ?are most effective at keeping cells alive under conditions that mimic the disorder, UT Southwestern Medical Center researchers report.

"These drugs have been tested in a variety of Huntington's disease models and some HD human trials and results are very difficult to interpret," said Dr. Ilya Bezprozvanny, associate professor of physiology and senior author of the study, available online and published in today's issue of Neuroscience Letters. "For some of these drugs conflicting results were obtained by different research groups, but it is impossible to figure out where the differences came from because studies were not conducted in parallel.

"We systematically and quantititatively tested the clinically relevant drugs side-by-side in the same HD model. That has never been done before," said Dr. Bezprozvanny.

Huntington's disease is a fatal genetic disorder, manifesting in adulthood, in which certain brain cells die. The disease results in uncontrolled movements, emotional disturbance and loss of mental ability. The offspring of a person with Huntington's have a 50 percent chance of inheriting it.

More than 250,000 people in the United States have the disorder or are at risk for it. There is no cure, but several drugs are used or are being tested to relieve symptoms or slow Huntington's progression.

The disease affects a part of the brain called the striatum, which is involved in the control of movement and of "executive function," or planning and abstract thinking. It primarily attacks nerve cells called striatal medium spiny neurons, the main component of the striatum.

Dr. Bezprozvanny's group previously demonstrated that Huntington's striatal neurons are oversensitive to glutamate, a compound that nerve cells use to communicate with each other.

'"/>

Source:UT Southwestern Medical Center


Page: 1 2

Related biology news :

1. A bacterial genome reveals new targets to combat infectious disease
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
4. NYU study reveals how brains immune system fights viral encephalitis
5. Study reveals new technique for fingerprinting environmental samples
6. Study reveals dramatic difference between breast cancers in US and Africa
7. UCSD research reveals mechanism involved with type of fatal epilepsy
8. Study reveals candidate targets for anti-retroviral therapeutics
9. Chimp genome reveals a retroviral invasion
10. Survey reveals women and doctors arent talking about HPV
11. Bioinformatics reveals new gene regulation system
Post Your Comments:
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... bacterial pneumonia in female mice to an enzyme activated ... naturally more resistant to respiratory infections than males. Now, ... resistance to bacterial pneumonia in female mice is linked ... also show that this enzyme is ultimately activated by ... The team, lead by Professor Lester Kobzik at the ...
(Date:10/14/2014)... cancer tumors scavenge and hoard copper that is an ... be a fatal weakness. , Researchers at Duke ... cells by delivering a trove of copper along with ... with the mineral, leaving non-cancer cells healthy. , The ... for other uses, could soon be tested in clinical ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Prostate cancer's penchant for copper may be a fatal flaw 2
... as the insects and plants in the network are ... question is difficult to answer because there is no ... or insects first appeared and almost none follow both ... Knight and her then postdoctoral research associate Laura Burkle ...
... on the challenge of providing the first insights into how ... with scientists from the John Innes Centre on a project ... Society and 2000 from the British Society for Plant Pathology., ... to Take-all, one of the most serious fungal diseases of ...
... everyone,s skin, yet one in five people is lucky enough ... In a boon for teenagers everywhere, a UCLA study conducted ... Los Angeles Biomedical Research Institute has discovered that acne bacteria ... may protect the skin. The findings, published ...
Cached Biology News:Walking in the footsteps of 19th and 20th century naturalists 2Walking in the footsteps of 19th and 20th century naturalists 3Walking in the footsteps of 19th and 20th century naturalists 4Walking in the footsteps of 19th and 20th century naturalists 5Growing talent -- schools to provide vital knowledge for food security 2New study could explain why some people get zits and others don't 2New study could explain why some people get zits and others don't 3
(Date:10/18/2014)... The Asian arthroscopic devices report defines and ... forecast of revenue. The arthroscopic devices market in Asia ... at a CAGR of 6.5% from 2013 to 2018. ... devices market, to get an idea of the in-depth ... segmentation of arthroscopic devices market in the same region, ...
(Date:10/18/2014)... 18, 2014 The Biomass Power ... the five years to 2014. The industry's expansion has ... tax credits that encouraged the use of biomass power. ... standards (RPSs), which require local utilities to generate electricity ... energy portfolio. Increased campaigning for green technology also influenced ...
(Date:10/17/2014)... a $451,781 Air Force Office of Scientific Research grant ... nano-scale level that will provide clues for predicting fatigue ... Aerospace Engineering, said the new technology and process would ... an aircraft,s wing., "We,ll be able to determine metal ... it on this scale," Huang said. "Certain patterns of ...
(Date:10/17/2014)... Horsham, PA (PRWEB) October 17, 2014 ... is being called upon by health facilities around ... exposed patients are being treated. Among the many ... used includes Texas Health Presbyterian Hospital Dallas and ... Center. The state-of-the-art vapor-producing robots have been utilized ...
Breaking Biology Technology:The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3UT Arlington project to detect possible damages in aircraft parts early in process 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6
... 2 Onyx,Pharmaceuticals, Inc. (Nasdaq: ONXX ) ... Healthcare Conference on Monday, January 7, at 11:30 ... webcast of the,presentation at:, http://www.metameetings.com/webcasts/jpmorgan/healthcare08 , ... 15 minutes early in order to,register and download ...
... CARLOS, Calif., Jan. 2 Nektar,Therapeutics, (Nasdaq: NKTR ... corporate presentation at the upcoming JPMorgan 26th Annual Healthcare,Conference ... California on,Tuesday, January 8, 2008, at 4:30 p.m. Pacific ... live audio and slideshow,webcast through a link posted on ...
... PRINCETON, N.J., Dec. 31 Pharmasset, Inc.,(Nasdaq: ... to,discovering, developing and commercializing novel drugs to treat ... year ended,September 30, 2007. Pharmasset reported a net ... $0.46 per share, as compared to a net ...
Cached Biology Technology:Pharmasset Reports Fiscal Year End 2007 Financial Results 2Pharmasset Reports Fiscal Year End 2007 Financial Results 3Pharmasset Reports Fiscal Year End 2007 Financial Results 4Pharmasset Reports Fiscal Year End 2007 Financial Results 5Pharmasset Reports Fiscal Year End 2007 Financial Results 6Pharmasset Reports Fiscal Year End 2007 Financial Results 7Pharmasset Reports Fiscal Year End 2007 Financial Results 8Pharmasset Reports Fiscal Year End 2007 Financial Results 9
... timer, SB3, Fully adjustable mixing angle, Variable ... to hold a number of different sized ... for aerating cultures, keeping biological samples in ... rotator can be used in incubators up ...
...
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
Fingerprinting II cluster analysis is an optional module that adds dendrogram and phylogenetic tree construction, cluster and group significance, and congruence of techniques functions to the Fingerp...
Biology Products: