Navigation Links
Temperature regulates circadian clock in zebrafish

The biological clock controls the circadian rhythms of a wide range of physiological and behavioral processes, from fluctuating hormone levels to sleep-wake cycles and feeding patterns. While it's well known that circadian clock elements sense and respond to light cycles, much less is known about how daily temperature cycles affect the clock's timing mechanism in vertebrates. In the open-access journal PLoS Biology, Kajori Lahiri, Nicholas Foulkes, and their colleagues study temperature related responses at the genetic and molecular level in zebrafish.

This genetically tractable model organism is especially suited to this task because adults, larvae, and even embryos can tolerate a wide range of core body temperatures (being cold-blooded animals) that can be manipulated simply by changing the water temperature. Temperature variations of as little as 2 oC (35.6 oF) can reset the zebrafish clock, Lahiri et al. show, and precise shifts in temperature trigger significant changes in the expression of specific clock genes. More explicitly, clock genes per4, cry2a, cry3, and clock1 showed rhythmic expression under temperature cycles when animals were raised in the dark, and the expression profiles during the high temperature phase matched those seen during a light phase when animals experienced light-dark cycles.

Zebrafish cell lines also proved valuable tools for studying temperature response, showing a similar pattern of clock gene expression during cycles of small temperature changes and continued entrainment of clock gene expression even after the cells were exposed to constant temperature. Acute temperature shifts can also trigger significant changes in clock gene expression (transcript levels of per4 and cry3 dropped after a temperature increase and spiked after a temperature decrease; cry2 showed the opposite response)--changes wrought by temperature-dependent shifts in the behavior of transcriptional regulators, as in the case of per4. '"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. Multi-purpose protein regulates new protein synthesis and immune cell development
2. Scientists identify molecule that regulates well-known tumor suppressor
3. MicroRNA gene that regulates lifespan found by Yale scientists
4. Research identifies protein in mice that regulates bone formation
5. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
6. Newly identified biomarker detects and regulates spread of brain tumors
7. Novel pathway regulates timing of brain cell development
8. Fruit fly study identifies gene mutation that regulates sensitivity to alcohol
9. Researchers first to map gene that regulates adult stem cell growth
10. After a time-shift, mixed signals from the circadian clock
11. The circadian clock: Understanding natures timepiece
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Temperature regulates circadian clock zebrafish

(Date:7/29/2014)... Achalasia is a rare disease it affects 1 in ... in the esophageal wall. While its cause remains unknown, a ... in Belgium, the University of Bonn in Germany and other ... autoimmune in origin. The study, published on 6 July in ... the mysterious disease. , When we swallow, a sphincter in ...
(Date:7/28/2014)... the U.S. Food and Drug Administration (FDA) for other ... pathogens inside human cells, including those that cause Legionnaires, ... in mBio , the online open-access journal of ... of identifying non-antibiotic drugs that could one day help ... on the list inhibit the growth of at least ...
(Date:7/28/2014)... researchers led by the University of Arizona has sequenced ... information will enhance scientists, and agriculturalists, understanding of the ... the development of new rice varieties that are better ... solve global hunger challenges. , The paper, "The genome ... evidence for independent domestication," was published online in ...
Breaking Biology News(10 mins):Mysterious esophagus disease is autoimmune after all 2New route to identify drugs that can fight bacterial infections 2Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4
... Cowman has won the Mahathir Science Award in Tropical ... the Academy of Sciences Malaysia, in recognition of his ... Foundation chairman Tun Ahmad Sarji Abdul Hamid made the ... to the global malaria research effort, leading studies into ...
... November 7, 2013 The knowledge and skills required to ... unavailable to those living with financial limitations. Competing demands ... achieving better diets. However, two researchers at the ... at the effects that three educational sessions might have ...
... associated with hydrocarbon extraction can negatively affect aquatic ... in the open-access journal PLOS ONE ... and other institutions. Hydrocarbons are a primary ... exploration and extraction are profitable enterprises, hydrocarbons contribute ...
Cached Biology News:Professor Alan Cowman wins Malaysian science award 23 'hands on' nutrition classes -- Enough to impact health behaviors in lower income women 2Drilling for hydrocarbons can impact aquatic life 2
(Date:7/30/2014)... 2014  RXi Pharmaceuticals Corporation (NASDAQ: ... on discovering, developing and commercializing innovative therapies ... technologies, today announced that their third Phase ... reduction of recurrence of hypertrophic scars following ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
(Date:7/30/2014)... 2014 Vala Sciences was recently ... Protection Agency (EPA). This new contract was awarded ... including tests designed to assess the effect of ... of connections between neurons (synapses), which are critical ... formation by environmental pollutants likely contributes to a ...
(Date:7/30/2014)... LayerBio, Inc., an MIT spinoff developing novel ... of seed financing from friends and family investors. Proceeds ... a novel sustained-release product for ophthalmology. , "We are ... commitment to this important work," said Dr. Ken Mandell, ... many areas in which innovations in drug delivery have ...
(Date:7/29/2014)... have hurdled a number of significant technological challenges ... observing technology originally created for the James Webb ... Investigator Harvey Moseley, a scientist at NASA,s Goddard ... that electrostatically actuated microshutter arrays that is, ... are as functional as the current technology,s magnetically ...
Breaking Biology Technology:RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4
... (OTCQB: AHRO) ("AtheroNova"), a biotech company focused on the research ... that it has appointed Johan M. (Thijs) Spoor as a ... effective January 3, 2012. Mr. Spoor is an independent director ... the Board. "I am very pleased to ...
... Inc., has initiated its transition from technology development ... Stan Rose, Ph.D., as the company,s first chief ... Sklar, M.D., Ph.D., has agreed to join the ... pioneering the development of a novel technology with ...
... Jan. 5, 2012  ZyGEM Corp. Ltd., a developer ... of DNA and other nucleic acids, and the ... (USAMRIID), today announced the signing of a Cooperative ... of simplified sample processing solutions for biothreat agents. ...
Cached Biology Technology:AtheroNova Announces a New Board Member 2AtheroNova Announces a New Board Member 3Nabsys Expands Leadership Team to Prepare for Commercialization of Novel DNA Positional Sequencing Technology 2Nabsys Expands Leadership Team to Prepare for Commercialization of Novel DNA Positional Sequencing Technology 3Nabsys Expands Leadership Team to Prepare for Commercialization of Novel DNA Positional Sequencing Technology 4ZyGEM and USAMRIID Sign CRADA for Development of Simplified Sample Processing Solutions for Biothreat Agents 2ZyGEM and USAMRIID Sign CRADA for Development of Simplified Sample Processing Solutions for Biothreat Agents 3
... smallest electronic pressure controller available measuring 26 ... this unit specifically for the analytical instrumentation ... carrier gas flow control, microfluidic flow control, ... focusing, the OEM-EPC offers external pressure sensor ...
... Stroke Thrust Slide is designed for heavy ... are limited and substantial side-loading is present. ... provide millions of trouble-free cycles even in ... bushings or recirculating ball bearings , Optional ...
... offered in several versions. The Captiva 0.2 ... are ideal to prepare precipitated protein samples ... and necessary to prevent clogging of expensive ... fiber and 20 um polypropylene filter plates ...
... CyScribe Post-Labeling Kit with CyScribe GFX ... generation and purification of Cy3- and ... for complete cDNA labeling and purification.Flexible ... for performing labeling reactions with either ...
Biology Products: