Navigation Links
Temperature regulates circadian clock in zebrafish

The biological clock controls the circadian rhythms of a wide range of physiological and behavioral processes, from fluctuating hormone levels to sleep-wake cycles and feeding patterns. While it's well known that circadian clock elements sense and respond to light cycles, much less is known about how daily temperature cycles affect the clock's timing mechanism in vertebrates. In the open-access journal PLoS Biology, Kajori Lahiri, Nicholas Foulkes, and their colleagues study temperature related responses at the genetic and molecular level in zebrafish.

This genetically tractable model organism is especially suited to this task because adults, larvae, and even embryos can tolerate a wide range of core body temperatures (being cold-blooded animals) that can be manipulated simply by changing the water temperature. Temperature variations of as little as 2 oC (35.6 oF) can reset the zebrafish clock, Lahiri et al. show, and precise shifts in temperature trigger significant changes in the expression of specific clock genes. More explicitly, clock genes per4, cry2a, cry3, and clock1 showed rhythmic expression under temperature cycles when animals were raised in the dark, and the expression profiles during the high temperature phase matched those seen during a light phase when animals experienced light-dark cycles.

Zebrafish cell lines also proved valuable tools for studying temperature response, showing a similar pattern of clock gene expression during cycles of small temperature changes and continued entrainment of clock gene expression even after the cells were exposed to constant temperature. Acute temperature shifts can also trigger significant changes in clock gene expression (transcript levels of per4 and cry3 dropped after a temperature increase and spiked after a temperature decrease; cry2 showed the opposite response)--changes wrought by temperature-dependent shifts in the behavior of transcriptional regulators, as in the case of per4. '"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. Multi-purpose protein regulates new protein synthesis and immune cell development
2. Scientists identify molecule that regulates well-known tumor suppressor
3. MicroRNA gene that regulates lifespan found by Yale scientists
4. Research identifies protein in mice that regulates bone formation
5. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
6. Newly identified biomarker detects and regulates spread of brain tumors
7. Novel pathway regulates timing of brain cell development
8. Fruit fly study identifies gene mutation that regulates sensitivity to alcohol
9. Researchers first to map gene that regulates adult stem cell growth
10. After a time-shift, mixed signals from the circadian clock
11. The circadian clock: Understanding natures timepiece
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Temperature regulates circadian clock zebrafish

(Date:5/17/2013)... 18, 2013) The AGA Research Foundation announced a ... relationship between the gut microbiota, one of today,s most ... , The AGA Research Awards Panel selected Andrew ... General Hospital and Harvard Medical School, Boston, as the ... Chan will receive $25,000 of funding, commencing in July ...
(Date:5/17/2013)... New Jersey, and City University of New York have ... that effectively clears organisms to be viewed under microscopes. ... which is one of the few high-quality clearing solutions ... Drug Enforcement Administration (DEA) due to its use as ... vital for viewing organisms under a microscope. Without them, ...
(Date:5/17/2013)... the interaction of a group of proteins in the ... identified a new target that could increase cell survival. ... School of Biochemistry and published in the EMBO ... eventually lead to new therapies for stroke and other ... by the team which identified a protein, known as ...
Breaking Biology News(10 mins):New gut microbiome research to explore red meat -- colorectal cancer pathway 2New formula invented for microscope viewing, substitutes for federally controlled drug 2New formula invented for microscope viewing, substitutes for federally controlled drug 3SUMO wrestling cells reveal new protective mechanism target for stroke 2
... is available in Spanish . , ... nematodes could improve the delivery, timing and use of ... machine is the result of a cooperative research and ... and Southeastern Insectaries, Inc., of Perry, Ga. The ...
... The Association for Molecular Pathology (AMP) opposed the ... the subject matter of a cancer-related proteonomics patent application ... submitted to NIH in response to a request for ... of Exclusive License: The Development of a Companion Diagnostic ...
... has no effect on the presence of large mammals in ... time compares the biological diversity of ecotourism zones with that ... biodiversity of areas that are not officially protected yet are ... to promote ecological tourism at the end of the 1980,s ...
Cached Biology News:Special delivery: Nematode-infected insect cadavers 2AMP opposes exclusive licensing of NIH proteomics patent 23 researchers in the Amazon clear up doubts as to the benefits of ecotourism 23 researchers in the Amazon clear up doubts as to the benefits of ecotourism 3
(Date:5/21/2013)... Through science fairs, workshops, kits for building optical ... organizations will continue their work to increase awareness about ... daily life with the aid of SPIE Education ... countries, are the first of two groups of recipients ... international society for optics and photonics , in 2013. ...
(Date:5/21/2013)... , May 21, 2013 The ... and Transplant Association) is the biggest congress in ... therapy. Nearly 10,000 participants are in Istanbul ... latest research findings. New pioneering studies have been presented: ... FERRIC PYROPHOSPHATE (SFP) ADMINISTERED VIA HEMODIALYSATE REDUCES ESA USE" ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Smarter Security, ... security solutions, today announced that Genzyme, a Sanofi company ... of Door Detective® CL for a multi-use facility in ... in four other Genzyme buildings, this latest order underscores ... the tailgate detection device improving doorway access ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Many have ... as contributor to acne. Recently physicians from Clinical ... mental stress on the skin, and suggested using ... reduce the chemicals produced from stress that cause acne. ... the negative feelings acne brings about, stress causes changes ...
Breaking Biology Technology:Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 2Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 3ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 2Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 3Adult Acne Treatment, Probiotic Action Explains How Hypnotherapy and Probiotics May Cure Various Skin Conditions 2
... law in New Jersey could be sign of things ... about workplace violence,is nowhere more acute than among healthcare ... to become the target of on-the-job violence than,their counterparts ... of horrific headlines, healthcare facilities understandably face,mounting pressure to ...
... RICHMOND, Va., July 9 Insmed Inc. (Nasdaq:,INSM), a ... Glover, President Insmed Therapeutics, will present at the,Collins Stewart ... 10:30 AM ET, in New York., The conference ... New,York City, from Tuesday, July 8 through Thursday, July ...
... -- Dr. Fernando Perez-Ruiz Joins Ardea,s Inflammatory Disease Scientific ... ... Ardea Biosciences, Inc.,(Nasdaq: RDEA ) today announced that it has ... RDEA806 in gout,patients with hyperuricemia. Gout, also known as metabolic arthritis, ...
Cached Biology Technology:Healthcare Industry Faces Mounting Pressure to Prevent On-The-Job Violence, Says Veteran Safety and Health Attorney 2Insmed to Present at Collins Stewart Fourth Annual Growth Conference 2Ardea Biosciences' Advances RDEA806 Into Phase 2a Proof-of-Concept Study for Gout 2Ardea Biosciences' Advances RDEA806 Into Phase 2a Proof-of-Concept Study for Gout 3Ardea Biosciences' Advances RDEA806 Into Phase 2a Proof-of-Concept Study for Gout 4
... for whole-blood clinical diagnostic work in hospitals ... this analyzer makes precise glucose measurements of ... lactate measurements of whole blood, plasma, or ... allows you to have glucose results expressed ...
... Cleanroom-grade vinyl curtains or ... powder-coated steel support frame to ... cleanroom that meets cleanliness to ... HEPA filter/fan units, lights, and ...
... BioSafe room is configured specifically for ... chemical analysis. Panels are precision-joined to ... to wipe down and disinfect. One-inch ... panel design creates strong, rigid surface ...
... The Varian 500-MS LC Ion Trap ... high-throughput LC/MS analysis where sensitivity, reliability ... 500-MS provides a robust platform for ... mass resolution, and mass stability reflect ...
Biology Products: