Navigation Links
Temperament linked to onset of cancer and early death in female rats

Female rats that are apprehensive of new experiences as infants maintain that temperament and die earlier from mammary and pituitary tumors than do their more adventuresome sisters, according to new research by a team based at the University of Chicago.

The apprehensive rats were more likely to have irregular reproductive cycles than adventuresome rats, and that disruption could account for hormonal differences linked to the development of cancer earlier, the scholars found. There was no difference in the length of time between onset of cancer and death in the two set of rats, however, the scholars found.

Because the findings have identified a difference in temperament that is associated with the onset of cancer, the findings may have implications for research on the development of cancer in humans, said Martha McClintock, the David Lee Shillinglaw Distinguished Service Professor in Psychology at the University of Chicago, and a member of the team that reports its findings in the paper "Infant Temperament Predicts Life Span in Female Rats that Develop Spontaneous Tumors" in the current issue of Hormones and Behavior.

Current human studies on the relationship between cancer and personality primarily focus on survival once a tumor has been identified.

"Human studies may need to consider more basic behavior traits than those already considered," McClintock explained. By understanding the development of basic traits, researchers will be better equipped to link the connections between personality and cancer development, the team suggests.

The links between behavior traits and cancer in rats are striking, the scholars found.

"This is the first evidence that infant temperament among rats predicts the time at which these tumors appear and the age at which the females will die," said lead author Sonia Cavigelli, a former University researcher who is now Assistant Professor in Biobehavioral Health Pennsylvania State Univer sity. Jason Yee, a graduate student in the Department of Comparative Human Development at University of Chicago researcher, is also an author of the paper.

For their study, the researchers selected 81 female Sprague-Dawley rat pups. The breed is prone to development of breast and pituitary tumors. In order to minimize the differences in temperament that are accountable to differences between rat families, the researchers compared behavior among sisters.

The rats were tested at 20 days and 11 months of age in a cage to see how willing they were to explore a new environment, which contained non-threatening items such as toys. The researchers measured adventuresomeness by recording how far the rats wandered in the environment.

They found that by age 390 days, middle age for rats, 80 percent of the fearful rats had mammary cancer while only 38 percent of the adventuresome rats had the illness. The fearful rats had a life span of 573 days, versus 850 for the adventuresome rats. They found similar life span results for females with pituitary tumors.

The researchers also monitored ovarian cycles daily from the time the rats were 55 days old until they were 450 days old. In studying their ovarian cycles, the scholars found that during puberty, the fearful rats were twice as likely as the adventuresome rats to have irregular cycles (52 percent, versus 22 percent). The cycles stabilized after the rats reached adulthood, and then became differentiated again during middle age with the fearful rats having irregular cycles more often. The aging affects on reproduction were also accelerated in the fearful rats.

In an earlier study, University of Chicago researchers looked at the lifespan of male rats and found that the adventuresome males lived longer. Because the male rats died of a variety of diseases, they could not establish a reason for the differences. The new study links personality specifically with cancer.


'"/>

Source:University of Chicago


Related biology news :

1. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
2. Low level of extinction during ice age linked to adaptability
3. Improved statistical tools reveal many linked loci
4. Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
5. Attacks of King George IIIs madness linked to key metabolism molecule
6. Gene controlling circadian rhythms linked to drug addiction
7. Physical and functional interaction of key cell growth molecules linked to cancer
8. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
9. Naturally occurring asbestos linked to lung cancer
10. Disappearing arctic lakes linked to climate change
11. Genes linked to treatment resistance in children with leukemia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... at the Pennsylvania Convention Center and will showcase its product’s latest features from ... also be presenting a scientific poster on Disrupting Clinical Trials in The Cloud ...
(Date:6/23/2016)... -- Amgen (NASDAQ: AMGN ) today announced a ... sciences incubator to accelerate the development of new therapies ... QB3@953 was created to help high-potential life science and ... stage organizations - access to laboratory infrastructure. ... "Amgen Golden Ticket" awards, providing each winner with one ...
(Date:6/22/2016)... , June 22, 2016 Research and ... Global Markets" report to their offering. ... billion in 2014 from $29.3 billion in 2013. The market is ... of 13.8% from 2015 to 2020, increasing from $50.6 billion in ... projected product forecasts during the forecast period (2015 to 2020) are ...
Breaking Biology Technology: