Navigation Links
Technique offers new view of dynamic biological landscape

A new technique for analyzing the network of genetic interactions promises to change how researchers study the dynamic biological landscape of the cell. The technology, which is called epistatic mini array profiles (E-MAP), has already been used to assign new functions to known genes, to uncover the roles of previously uncharacterized proteins, and to define how biochemical pathways and proteins interact with one another.

E-MAP will enable new understanding of how genes and proteins function in the cell, said Jonathan S. Weissman, a Howard Hughes Medical Institute (HHMI) investigator at the University of California, San Francisco (UCSF) and leader of the team that developed the technique. For example, E-MAPs of human gene interactions could enable researchers to optimize drug treatments to patients' genetic backgrounds. It might also be possible to use E-MAP to develop effective combinations of antiviral drugs that target proteins produced by interacting genes. Such a strategy would help to prevent these genes from acting together to compensate for an attack on just one protein, said Weissman.

The researchers, led by Weissman, Maya Schuldiner, a post-doctoral fellow working in his lab, and Nevan Krogan at the University of Toronto, described initial studies of E-MAP in yeast in the November 4, 2005, issue of the journal Cell. Weissman and his colleagues at UCSF collaborated on the studies with researchers at the University of Toronto.

Previous techniques for analyzing epistatic interactions -- how the activity of one gene affects that of another -- involved altering single genes and analyzing their impact on growth in combination with all other genes in the yeast genome. "The one-to-one method has been an extremely powerful way of studying biological systems," said Weissman. "But we wanted to approach such analyses in a systematic way and to use the new generation of high-throughput technology to quantitatively explore large numbers
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. New Technique for Tracking Gene Regulators
2. Live Recombinant Adenovirus Vaccine Technique Explored
3. Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
4. Researchers Find New Technique To Identify Fetal Genetic Material From Amniotic Fluid
5. Techniques available to detect soil that inhibits destructive soybean pest
6. Technique makes it easier to see mouse embryo in all its glory
7. Technique speeds up detecting, treating wound bacteria
8. Technique monitors thousands of molecules simultaneously
9. Protein offers way to stop microscopic parasites in their tracks
10. Gene silencing technique offers new strategy for treating, curing disease
11. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Technique offers new view dynamic biological landscape

(Date:5/18/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
(Date:5/14/2015)... 14, 2015  Verificient Technologies, Inc., a ... online remote proctoring, announced a new alliance ... and creator of the Canvas Learning Management ... companies will benefit from the seamless integration ... As a fully integrated multifactor biometrics behavioral ...
(Date:5/11/2015)... May 11, 2015  Through a well-rounded UAS delegation representing ... had a strong showing at AUVSI,s Unmanned 2015 conference last ... Ohio,s UAS industry met with over ... all points along the UAS ecosystem. "Our ... Vice President for Aerospace Rich Knoll . "If you ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
... which could alleviate the suffering of millions of people with ... clinical testing in patients. Developed and patented by ... with FV-100 has recently been initiated in America. Previous ... times more potent than existing treatments in early lab tests. ...
... of Duchenne Muscular Dystrophy (DMD) for 2 years ... the same length of delay children have endured for ... and treatment. A simple and inexpensive blood test for ... and abnormalities could speed up the process while pilot ...
... (LSTM) has been awarded a 1.1m grant by the ... year project to develop a Field Applicable Screening Tool ... in mosquitoes. The two principal methods for control ... insecticide-treated bednets (ITNs) and indoor residual spraying (IRS) of ...
Cached Biology News:Clinical trials for shingles drug take an important step forward 2Muscular dystrophy diagnosis delayed almost 2.5 years in boys 2$1.6 million grant to lead development of resistance-detecting field kit 2
(Date:5/20/2015)... FRANCISCO, Calif. , May 20, 2015 /PRNewswire/ ... ) today presented preliminary data demonstrating the ability ... idiopathic pulmonary fibrosis (IPF) from other interstitial lung ... findings suggest the classifier,s potential to help thousands ... to resolve ambiguity in IPF diagnosis – a ...
(Date:5/20/2015)... 19, 2015 Research and Markets ( ... "Global Cell Therapy Market Outlook 2020 " report ... in tissue and regenerative medicine is expected to have ... which could help in the growth of deregulated organs. ... they are unable to form new tissue or sometimes ...
(Date:5/20/2015)... 2015  Health eCareers, the healthcare industry,s online ... job seekers looking for the flexibility of short-term ... and online tool dedicated exclusively to temporary and ... SHIFT enables employers to quickly find and hire ... diem and other temporary positions, eliminating the time ...
(Date:5/20/2015)...  Haemonetics Corporation (NYSE: HAE ) announced today ... present at The Jefferies 2015 Global Healthcare Conference in ... st , 2015 at 8:30am Eastern time.  ... via webcast at: http://wsw.com/webcast/jeff88/hae ... is a global healthcare company dedicated to providing innovative ...
Breaking Biology Technology:Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3
... PARS ) today reported results for the first quarter ended ... million, or $0.14 per share,for the first quarter 2008 compared ... in the first quarter 2007. Cash and short-term investments,totaled $11.3 ... loss for the first quarter 2008 is due primarily to,a ...
... IRVINE, Calif., May 8 Edwards Lifesciences,Corporation (NYSE: ... heart valves,announced that the company will celebrate a number ... annual meeting of the American,Association for Thoracic Surgery (AATS), ... marked by Edwards -- which this year celebrates,its 50th ...
... Additional Investors ... Next Growth Phase, SAN DIEGO, May 8 CardioDynamics (Nasdaq:,CDIC), ... the reverse split of 1 for 7 shares of the,Company,s common ... earlier today., The record date for the reverse split has ...
Cached Biology Technology:Pharmos Corporation Reports 2008 First Quarter Results 2Pharmos Corporation Reports 2008 First Quarter Results 3Pharmos Corporation Reports 2008 First Quarter Results 4Edwards Lifesciences Celebrates One Million Heart Valve Patients and More at AATS 2008 2Edwards Lifesciences Celebrates One Million Heart Valve Patients and More at AATS 2008 3Edwards Lifesciences Celebrates One Million Heart Valve Patients and More at AATS 2008 4CardioDynamics Shareholders Approve One-for-Seven Reverse Split of Company's Common Stock and Trading in Post-split Shares Begins May 9, 2008 2CardioDynamics Shareholders Approve One-for-Seven Reverse Split of Company's Common Stock and Trading in Post-split Shares Begins May 9, 2008 3
Moue Serum 8-12 Weeks Old...
... is collected off the clot fasted non-Swiss Albino mice ... Available Anticoagulants: N-02: Citrate N-04: ... Potassium Oxalate N-10: EDTA (Na) ... CPD N-09: K3EDTA N-11: ...
Contains 100 positive controls for effective screening of HDAC inhibitors by fluorometric method....
dynactin 4, mRNA (cDNA clone MGC:3248 IMAGE:3505855), complete cds...
Biology Products: