Navigation Links
Technique monitors thousands of molecules simultaneously

A chemist at Washington University in St. Louis is making molecules the new-fashioned way ?selectively harnessing thousands of minuscule electrodes on a tiny computer chip that do chemical reactions and yield molecules that bind to receptor sites. Kevin Moeller, Ph.D., Washington University professor of chemistry in Arts & Sciences, is doing this so that the electrodes on the chip can be used to monitor the biological behavior of up to 12,000 molecules at the same time.

The work is motivated by a desire to map the three-dimensional requirements of biological receptors on cell surfaces. Typically, receptors bind small molecules through a lock and key mechanism where the molecule is the key and the receptor the lock. The nature and shape of molecules that serve as keys tells about the binding requirements of the receptor. Traditionally, probing a receptor this way has been done by making a library of molecules, treating it with the receptor, washing away any excess receptor that has not found a key, and then treating the bound receptors with an antibody that recognizes the receptor and is tagged to a fluorescent label. The washing step risks removing a bound receptor if it does not bind the molecular key strongly enough. But, with an electrochemically addressable computer chip, provided in great abundance by one of his sponsor's, CombiMatrix in Seattle, Moeller saw a way of probing the binding of a library with a receptor without the need for washing by putting each member of the molecular library by an electrode that can then be used to monitor its behavior.

The electrochemically addressable chips being used represent a new environment for synthetic organic chemistry, changing the way chemists and biomedical researchers make molecules, build molecular libraries and understand the mechanisms by which molecules bind to receptor sites.

"We believe we can move most of modern synthetic organic chemistry to this electrochemically addressable ch
'"/>

Source:Washington University in St. Louis


Page: 1 2 3 4

Related biology news :

1. New Technique for Tracking Gene Regulators
2. Live Recombinant Adenovirus Vaccine Technique Explored
3. Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
4. Researchers Find New Technique To Identify Fetal Genetic Material From Amniotic Fluid
5. Techniques available to detect soil that inhibits destructive soybean pest
6. Technique offers new view of dynamic biological landscape
7. Technique makes it easier to see mouse embryo in all its glory
8. Technique speeds up detecting, treating wound bacteria
9. One signal elicits thousands of answers
10. Hundreds of thousands of viral species present in the worlds oceans
11. Ebola outbreaks killing thousands of gorillas and chimpanzees
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Technique monitors thousands molecules simultaneously

(Date:8/20/2014)... a study of 158 pregnant teenagers in Rochester, NY, ... intentional consumption of ice, cornstarch, vacuum dust, baby powder ... Cornell study. , Moreover, such teens had significantly lower ... eat nonfood substances. , Pregnant teens, regardless of pica, ... lead to iron deficiency and anemia. Low iron in ...
(Date:8/20/2014)... life can persist in a cold, dark world. A ... that examined waters and sediments from a shallow lake ... extreme environment supports microbial ecosystems. , The National ... has implications for life in other extreme environments, both ... are published in the current edition of the science ...
(Date:8/20/2014)... Arizona State University, the Wellcome Trust Sanger Institute and ... isolated Mycobacterium pinnipedii from skeletons found in ... pathogen is a relative of the TB bacterium that ... today. These researchers assume that seals carried the pathogens ... sea lions was unexpected" comments Sebastien Gagneux, from the ...
Breaking Biology News(10 mins):Pica in pregnant teens linked to low iron 2University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2
... disease affecting a person,s ability to coordinate and control ... in a finger will eventually lead to difficulty in ... without assistance. Since the 1950s research has shown that ... dopamine in their brains, which is involved in sending ...
... in rehabilitating goats and other animals that have suffered from ... In this first scientific study of rescued animals, ... had endured poor welfare, such as inappropriate diet, and lack ... created a spatial awareness test, which involved giving the animals ...
... April 22, 2013 The U.S. Farmers  & Ranchers ... multiple disciplines, including farmers, media, industry and academia,  to ... discussion was moderated by CNBC Senior Analyst and Financial ... Chicago , which took place during the ...
Cached Biology News:New research examines connection between inflammatory stimulus and Parkinson's disease 2New research examines connection between inflammatory stimulus and Parkinson's disease 3Rescue me: New study finds animals do recover from neglect 2CNBC Senior Analyst Ron Insana Moderates Discussion On Biotech Seeds At The Food Dialogues(SM): Chicago 2CNBC Senior Analyst Ron Insana Moderates Discussion On Biotech Seeds At The Food Dialogues(SM): Chicago 3
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the Netherlands to ... Majesty Willem-Alexander, King of the Netherlands, has announced that ... Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant in Emmetsburg, ... take part in the Grand Opening Ceremony to perform ... and tour the plant. POET-DSM is a joint venture ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... in Brazil and ... restrictions. The uptake of several newly approved agents, ... for this indication and the launch of emerging ... asthma markets. In particular, the emerging IL-5 inhibitors ...
(Date:8/21/2014)... HONG KONG , Aug. 21, 2014  China Cord ... today announced its plan to release financial results for ... August 28, 2014, after market close in the US.  ... call at 8:00 a.m. ET on Friday, August 29, ... brief overview of the Company,s recent developments, followed by ...
(Date:8/21/2014)... Bulgaria (PRWEB) August 21, 2014 ... released today by Ontotext . Now the ... semantic analysis of structured and unstructured data is available ... the cost of enterprise technology. Organizations that do not ... for data management can use S4 since there is ...
Breaking Biology Technology:His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... , ... , , , ... in the homeostasis of cell numbers in adult,organisms, furthermore in eliminating ... two distinct ways of,eukaryotic cell death: oncosis and apoptosis. How cells,die ...
... , , ... , , , ... and thymidylate,synthase (TS) play a pivotal role in the metabolism,of ... is the standard,chemotherapy treatment for a wide range of solid,tumors. ...
... , , ... , Since the first description of ... a few years ago, RNAi has become a powerful,tool for analyzing ... that are,homologous to the suppressed gene. These small interfering,RNAs (siRNAs) of ...
Cached Biology Technology:Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 2Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 3Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 4Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 5Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 6Gene-Expression Analysis of TP, DPD, and TS Using,the LightCycler mRNA Quantification KitsPLUS 2Gene-Expression Analysis of TP, DPD, and TS Using,the LightCycler mRNA Quantification KitsPLUS 3Gene-Expression Analysis of TP, DPD, and TS Using,the LightCycler mRNA Quantification KitsPLUS 4Quantification of siRNA Silencing Efficiency,Using the LightCycler System 2Quantification of siRNA Silencing Efficiency,Using the LightCycler System 3Quantification of siRNA Silencing Efficiency,Using the LightCycler System 4Quantification of siRNA Silencing Efficiency,Using the LightCycler System 5
... Effectively condenses and traps a wide variety ... vacuum pump oil. Easy-to-use glass condensation flask (GCF400) ... self contained jar for easy draining. Rapid cooling ... remove glass flask for quick solvent changes ...
... Analysis Note: Protein determined by Biuret ... 25 mM Tris-HCl, pH 7.6, 1 mM ... 2 Preparation Unit Definition: One unit ... per minute at pH 9.8 at 37 ...
Immulon 2 HB 1x8 Strip assembled, C-bottom; high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes....
Immulon 2HB, Flat Bottom, 50/Bx; high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes....
Biology Products: