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Tearing down the fungal cell wall

directs the synthesis of secondary metabolites known as non-ribosomal peptides. However, the functions of many of these proteins and the subsequent synthesized metabolites are largely unknown. Dr. Lawrence added: "To the best of our knowledge, this is the first report that a fungal non-ribosomal peptide synthetase is associated with cell wall construction in fungal spores. The putative secondary metabolite produced by the protein encoded by this gene could serve as a physical bridge in the layers of the cell wall or function as a regulator of cell wall biosynthesis. Future work will focus on identifying the role of the product of the AbNPS2 gene which should allow us to get an important handle on the precise series of molecular events that give rise to these drastic effects on spore viability."


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Source:Virginia Tech


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