Navigation Links
Targeting tumors the natural way

By mimicking Nature's way of distinguishing one type of cell from another, University of Wisconsin-Madison scientists now report they can more effectively seek out and kill cancer cells while sparing healthy ones.

The new tumor targeting strategy, presented today (March 25) at the annual national meeting of the American Chemical Society, cleverly harnesses one of the body's natural antibodies and immune responses. "The killing agent we chose is already in us," says UW-Madison chemistry professor Laura Kiessling, who led the work with postdoctoral researcher Coby Carlson. "It's just not usually directed toward tumor cells."

In a series of cell-based experiments, the researchers' system recognized and killed only those cells displaying high levels of receptors known as integrins. These molecules, which tend to bedeck the surfaces of cancer cells and tumor vasculature in large numbers, have become important targets in cancer research.

In contrast, an established tumor-homing agent linked to the cell toxin doxorubicin destroyed cells even when they expressed very little integrin, indicating this strategy has the potential to kill cancerous and healthy cells indiscriminately.

"This study suggests that the cell recognition mode we used can direct an endogenous immune response to destroy cancer cells selectively," says Kiessling. "We think this could lead to a new class of therapeutic agents not only for cancer but also for other diseases involving harmful cells."

Cancer cells typically display higher levels of certain receptors on their surfaces than do normal cells, a fact that allows scientists to pinpoint tumor cells lurking among the body's scores of cell types. A popular approach employs a cell-binding agent, such as a monoclonal antibody, that is powerfully attracted to the target receptor and holds fast to any cell displaying it.

Although this strategy has benefits, it's not natural, says Kiessling. Cell recogni
'"/>

Source:University of Wisconsin-Madison


Page: 1 2 3

Related biology news :

1. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
2. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
3. Targeting sugar on blood vessels may inhibit cancer growth
4. Mouse brain tumors mimic those in human genetic disorder
5. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
6. Pulsating ultrasound enhances gene therapy for tumors
7. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
8. Vaccine targets tumors where they live
9. Breast tumors in mice eradicated using cancer vaccine
10. Optimizing cell therapy against tumors is a balancing ACT
11. A new link between stem cells and tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Targeting tumors the natural way

(Date:12/17/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) ... Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this ... in biomedical applications. Chemical sensors help in recording ... during surgical procedures. The Global Chemical Sensor market ...
(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of ... report to their offering. One ... adoption of multimodal biometric systems. Multimodal biometric systems ... for verification and identification purposes. This helps to ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... unknown to science have been discovered on the seafloor ... hydrothermal vents. The discoveries, made by teams led ... British Antarctic Survey, include new species of yeti crab, ... For the first time, researchers have used a Remotely ...
... out closely related species and managing each type on ... management system. Some species, like the two types ... behavior that differentiation can be challenging. Conservation researchers at ... developed a mechanism for identifying these reclusive species from ...
... manipulating the way bacteria "talk" to each other, researchers ... of control over the formation and dispersal of biofilms ... applications, particularly to bioreactor technology. Working with ... Associate Professor Arul Jayaraman of the university,s Artie McFerrin ...
Cached Biology News:'Lost world' discovered around Antarctic vents 2Manipulating way bacteria 'talk' could have practical applications, Texas A&M profs say 2Manipulating way bacteria 'talk' could have practical applications, Texas A&M profs say 3
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/fhh9rj/technology ) ... Innovations in Smart Fabrics (Technical Insights)" report ... http://photos.prnewswire.com/prnh/20130307/600769 The Research Service titled ... assessment on technological advancements and market for Smart ... 1. The Smart Fabrics market is expected to ...
(Date:12/19/2014)... CAMBRIDGE, MA (PRWEB) December 18, 2014 ... adults in the United States suffer from one or ... arthritis, asthma, or cancer. Medication can address some of ... to daily activities that many sufferers face. While implanted ... surgery and stimulate the whole nerve, which can induce ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group ... dental biomaterial market will grow moderately through 2023 as ... and growing awareness of dental biomaterials all spur procedure ... such as China and ... bring dental procedures within reach for a larger proportion ...
(Date:12/17/2014)... Based on the revenues gained from surgical imaging ... by four major players contributing to approximately 74% ... GE Healthcare (U.K.), Siemens AG (Germany), Philips (Netherlands), ... Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , The leading ... its strong product portfolio, which includes its flagship ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... Exciting new data presented today at ... causal role in the development of diabetes and non-alcoholic ... 1] . Though an early stage animal model, the ... NAFLD with gut microbiota transplantation - the engrafting of ...
... can restore complex hand movements in monkeys following paralysis, ... of Health. In a report in the journal ... pieces of technology to create a neuroprosthesis a ... One piece is a multi-electrode array implanted directly into ...
... component of the James Webb Space Telescope is its new ... be conceived, designed and built specifically to enable it to ... advances, some of the innovations are being used to benefit ... the world,s next-generation space observatory and successor to the Hubble ...
Cached Biology Technology:Gut Microbiota Transplantation may Prevent Development of Diabetes and Fatty Liver Disease 2Gut Microbiota Transplantation may Prevent Development of Diabetes and Fatty Liver Disease 3Brain-activated muscle stimulation restores monkeys' hand movement after paralysis 2Brain-activated muscle stimulation restores monkeys' hand movement after paralysis 3Webb Telescope spinoff technologies already seen in some industries 2Webb Telescope spinoff technologies already seen in some industries 3Webb Telescope spinoff technologies already seen in some industries 4
Sheep polyclonal to Salmonella Shoreditch ( Abpromise for all tested applications). Antigen: Native Salmonella shoreditch (Group D2)....
anti-achaete...
... Super-Sensitive, Super-Dark, Super-Small! ... with the ChemiDoc-It Imaging System. High-sensitivity ... produces low-background noise and wide dynamic ... a short exposure time. The light-tight ...
... Based Oligonucleotide) Genome Set and MEEBO (Mouse ... contain a collection of open source oligo ... allowing interrogation of thousands of genes. Developed ... University and UCSF, the sets enable the ...
Biology Products: