Navigation Links
Targeting sugar on blood vessels may inhibit cancer growth

uced by Genentech, has been shown to block a major pro-angiogenesis molecule called vascular endothelial growth factor (VEGF), thus inhibiting the growth of vasculature. The drug has been used along with chemotherapy in humans to successfully inhibit the growth of tumors in colon and lung cancers.

"If novel drugs can be developed to target tumor heparan sulfate, we might be able to make a leap in cancer-fighting therapies, because several molecules critical to tumor endothelial growth also bind to heparan sulfate," Fuster said. "Altering this binding would allow for suppression of a broader array of the tumor ‘fuels?for angiogenesis, without a major effect on normal vascular function."

The researchers hope to develop novel therapies by inhibiting endothelial heparan sulfate in the tumor environment. An example would be developing small-molecule inhibitors of Ndst1. By affecting a broad array of molecules ?such as VEGF, fibroblast growth factor, platelet-derived growth factor, or others that impact angiogenesis in a variety of carcinomas ?this therapy could be used to inhibit cancer growth and metastasis with fewer side effects.
'"/>

Source:University of California - San Diego


Page: 1 2

Related biology news :

1. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
2. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
3. Targeting tumors the natural way
4. Thai spice helps cut blood sugar swings
5. Cats indifference towards sugar explained
6. Life-extending protein keeps blood sugar in check
7. Too much sugar not good for coral reefs
8. Darkness unveils vital metabolic fuel switch between sugar and fat
9. Scientists seek to unwrap the sweet mystery of the sugar coat on bacteria
10. A single sugar found responsible for an antibodys ability to treat inflammation
11. Researchers attack tumor cells by exploiting dependency on sugar metabolism
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Targeting sugar blood vessels may inhibit cancer growth

(Date:12/10/2014)... RALEIGH, N.C. , Dec. 9, 2014  Valencell, ... announced it is seeing a staggering demand from its ... demand, the Company revealed, is not solely coming from ... industries as well. "A wearable is only ... a result, accuracy is the ultimate driver in long-term ...
(Date:12/10/2014)... CIE San Diego has launched an innovative ... tissue that enhances care coordination among social service and ... information; earned a second $1 million grant from the ... aging in community and; will be recognized as a ... 4-6p. CIE San Diego today announced ...
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... coin or a watch can be dangerous for people ... is allergic to the metal. "This raises the question ... Professor Dr. Markus Rettenmayr of the Friedrich Schiller University ... for cardiovascular implants in minimal invasive surgery. Once implanted, ...
... CHICAGO Solving crucial environmental issues such as ... interests, uncertainty and risk, and this is best ... Arizona State University Barrett Honors College ... which scientists, stakeholders and policy makers can communicate ...
... a range of climate change mitigation scenarios are discussed, ... of sulfate particles into the atmosphere to reflect sunlight ... a severe threat if not maintained indefinitely and supported ... The new study, published today, 18 February, in IOP ...
Cached Biology News:Metal in the heart is non-hazardous to health 2Environmental issues examined through cohesive efforts 2Researchers warn against abrupt stop to geoengineering method 2
(Date:12/25/2014)... 2014 The report “Service ... Market by Product Type & Provider Type ... (2014-2019)” defines and segments the market with ... , Browse 152 market data tables, ... in-depth TOC on “Service Quality Management (SQM) ...
(Date:12/24/2014)... SILVER SPRING, Md. , Dec. 24, 2014 ... ) announced today that Medtronic, Inc. (NYSE: ... application to the U.S. Food and Drug Administration ... II implantable drug infusion system (including a ... Remodulin ® (treprostinil) Injection delivered intravenously to ...
(Date:12/24/2014)... and NEW YORK , Dec. 24, ... a biopharmaceutical company advancing patient care in critical areas, ... 3,500,000 shares of common stock, and warrants to purchase ... at an offering price of $4.00 per share and ... exercise price of $5.00, are exercisable immediately, and expire ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a ... today that the Company closed its previously announced ... Jack W. Schuler , Birchview Fund LLC ... million, before offering expenses.  The proceeds will be ... Under the terms of the private ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... , , ... , , , Duplications and ... different methods are used for detecting such rearrangements,most based on either ... accurate, but very labour intensive and expensive,while quantitative PCR methods are ...
... , ... , , , Slab ... the separated bands,of an unknown sample to a known,standard (size ... estimated. The Agilent,2100 bioanalyzer is an instrument,which utilizes LabChip,technology to ...
... , , ... , , , , Gene expression ... for analyzing cellular behavior in a micro,scale and is used in ... of RNA from specific cell,populations out of their surrounding tissue environment. ...
Cached Biology Technology:Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 2Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 3Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 4Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 5High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 2High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 3High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 4High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 5Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 2Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 3Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 4Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 5Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 6Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 7Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 8
... Polymerase is ideal for high-fidelity amplification ... such as cloning and mutagenesis. ... proprietary enzyme preparation containing recombinant DNA ... (3'Cut Site5' exonuclease) activity. Platinum ...
... PLAU N-term Antibody This antibody is generated ... synthetic peptide selected within aa 50~150 of ... in PBS with 0.09% (W/V) sodium azide. ... G column and eluted out with both ...
...
Human interferon-beta (IFN-beta). Recognizes amino acids 30-47 of IFN-beta. No cross-reactivity with Human IFN-alpha or IFN-gamma....
Biology Products: