Navigation Links
Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

Silencing Alzheimer's: targeting a key enzyme with gene therapy reversed course of disease in mouse modelsIn mice, that had been genetically engineered to develop Alzheimer's disease, scientists were able to reverse the rodents' memory loss by reducing the amount of an enzyme that is crucial for the development of Alzheimer's disease.

"What we are showing is a proof of principle that stopping the synthesis of a protein that is necessary for the formation of the telltale plaques reverses the progression of the disease, and more importantly, the cognitive function of these mice, which had already been impaired, has now recovered," says Inder Verma, professor in the Laboratory for Genetics at the Salk Institute for Biological Studies.

The findings, which are the result of a close collaboration between researchers at the Salk Institute and scientists at the University of California in San Diego, are reported in an advance on-line publication of Nature Neuroscience.

In the past, gene therapy has been mainly used to deliver normal genes into cells to compensate for defective versions of the gene causing disease. In their study, the researchers used gene therapy to silence a normally functioning gene. Exploiting a mechanism called RNA interference, they were able to turn down the gene that helps produce the characteristic amyloid plaques that are one of the hallmarks of Alzheimer's disease.

"Within a month of treatment, mice that had already suffered memory deficits could learn and remember how to find their way through a water maze," says co-author Robert Marr, a post-doctoral researcher in Verma's lab.

"It appears that these mice can come back from a very severe level of disease progression," adds first author Oded Singer, also at the Salk. "This is a very important finding because humans are usually diagnosed when the disease has already progressed relatively far."

But he warns that it is too early to make direct comparison
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
2. Targeting tumors the natural way
3. Targeting sugar on blood vessels may inhibit cancer growth
4. Lack of enzyme turns fat cells into fat burners
5. Scientists find missing enzyme for tuberculosis iron scavenging pathway
6. Researchers report new pro-inflammatory role for anti-inflammatory enzyme
7. Purdue researchers use enzyme to clip DNA wires
8. Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
9. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
10. UCLA researchers identify key enzyme linked to childhood blindness
11. K-State professors discover enzyme responsible for creation of a beetles hard shell
Post Your Comments:
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... microcontroller (MCU) and touch technology solutions, today launched the ... with the widest V cc range from ... accuracy and faster I 2 C bus communication speeds, ... EEPROM memory making them ideal for consumer, industrial, computer, ...
(Date:11/18/2014)... , Nov. 17, 2014 The Parenteral Drug Association ... regulatory agencies will speak and at least seven more will ... at the Omni Shoreham Hotel in Washington D.C. ... again to have significant support from the regulatory agencies in ... Europe in our effort to help advance the ...
(Date:11/12/2014)... , Nov. 12, 2014 Crossmatch™, a ... that its U.are.U ® fingerprint readers have been ... in Central Mexico . The bakery ... to eliminate payroll issues caused by employees clocking in ... the U.are.U fingerprint readers, Montparnasse relied on paper timecards ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... of Rochester Medical Center scientists have demonstrated a new ... sometimes dangerous E. coli bacteria. , The unique technology ... of the sensing system that also includes a silicon ... and Bioelectronics published an article on the technology in ...
... clinical trial demonstrate that high doses of an experimental ... healthy adults. , Approximately half of those volunteers ... the highest dosage of the vaccine tested in the ... predict would neutralize the virus. The National Institute of ...
... estate may be its most important feature to many ... San Diego (UCSD) and the University of Virginia have ... distributed along the chromosomes of bacteria and simpler organisms ... , In a paper published Jan. 13 online in ...
Cached Biology News:Rochester scientists develop fast-working biosensor 2H5N1 avian flu virus vaccine induces immune responses in healthy adults 2H5N1 avian flu virus vaccine induces immune responses in healthy adults 3Patterns in genome organization may partially explain how microbial cells work 2Patterns in genome organization may partially explain how microbial cells work 3
(Date:12/17/2014)... (PRWEB) December 17, 2014 Audacity, a ... agency and member of the Huntsworth Health Group, is ... its executive team. In her role, Gonzales will serve ... “We are incredibly honored to welcome a talent of ... and CEO, Gaëtan Fraikin. “She is a proven healthcare ...
(Date:12/17/2014)...   Synageva BioPharma Corp. (NASDAQ: ... rare disorders, announced today its presentation at the upcoming ... San Francisco, CA. Sanj ... present on Monday, January 12, 2015, at 9:00 a.m. ... live and may be accessed from the "Webcasts & ...
(Date:12/15/2014)... Agritech Limited (NASDAQ GS: SEED) (" Origin ", or the ... China , today announced that the Company ... 30, 2014, before the market opens on Thursday, January 8, ... January 8, 2015, at 8:00 a.m. ET / 9:00 p.m. ... To participate in the call, please dial +1-888-346-8982 in ...
(Date:12/13/2014)... The DNA Microarray market market was ... expected to grow at a CAGR of 15.2% ... TOC of the DNA Microarray for an in-depth ... help of various tables and figures. , ... consists of instrument, consumables, and services, where the ...
Breaking Biology Technology:Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 2DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 4
... fusions in lysates of the yeast Saccharomyces cerevisiae using the , ... , Paul Gavin # and Mark Prescott # ... # Department of Biochemistry and Molecular ... Australia , * Technical assistance: Varian Australia Pty ...
... Overview , Affinity ... number of biological molecules. For example, antibodies may be purified based ... purified on the basis of its affinity for a monospecific antibody ... column with a relatively large volume. This note discusses the use ...
... Purpose , ... be identified and quantified more effectively and efficiently using LC/MS/MS. These ... challenges. , Overview ... safety organizations worldwide are placing great importance on the identification and ...
Cached Biology Technology: Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 2 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 3 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 4Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 2Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 3Identification of Insecticides and Herbicides by LC/MS/MS Using the API 2000 LC/MS/MS System 2
... Using the New FAST(tm) Frame Multi-Slide Plate! ... designed to hold four, 16-pad FAST Slides ... a microplate footprint for high throughput processing ... standards recommended by the Society of Biomolecular ...
... Package Superior Protein Detection and Quantitation ... 2D Proteomic Imaging System is a highly ... general life science research applications. ProXPRESS 2D ... all dyes in the UV and VIS ...
fully automated system for the processing of microarrays on microscope slides...
... Blot includes 7 lanes ... from Alzheimer's-diseased brain tissue ... gyrus, frontal lobe, temporal ... lobe and cerebellum. Patent/trademark/license ...
Biology Products: