Navigation Links
Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

Silencing Alzheimer's: targeting a key enzyme with gene therapy reversed course of disease in mouse modelsIn mice, that had been genetically engineered to develop Alzheimer's disease, scientists were able to reverse the rodents' memory loss by reducing the amount of an enzyme that is crucial for the development of Alzheimer's disease.

"What we are showing is a proof of principle that stopping the synthesis of a protein that is necessary for the formation of the telltale plaques reverses the progression of the disease, and more importantly, the cognitive function of these mice, which had already been impaired, has now recovered," says Inder Verma, professor in the Laboratory for Genetics at the Salk Institute for Biological Studies.

The findings, which are the result of a close collaboration between researchers at the Salk Institute and scientists at the University of California in San Diego, are reported in an advance on-line publication of Nature Neuroscience.

In the past, gene therapy has been mainly used to deliver normal genes into cells to compensate for defective versions of the gene causing disease. In their study, the researchers used gene therapy to silence a normally functioning gene. Exploiting a mechanism called RNA interference, they were able to turn down the gene that helps produce the characteristic amyloid plaques that are one of the hallmarks of Alzheimer's disease.

"Within a month of treatment, mice that had already suffered memory deficits could learn and remember how to find their way through a water maze," says co-author Robert Marr, a post-doctoral researcher in Verma's lab.

"It appears that these mice can come back from a very severe level of disease progression," adds first author Oded Singer, also at the Salk. "This is a very important finding because humans are usually diagnosed when the disease has already progressed relatively far."

But he warns that it is too early to make direct comparison
'"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
2. Targeting tumors the natural way
3. Targeting sugar on blood vessels may inhibit cancer growth
4. Lack of enzyme turns fat cells into fat burners
5. Scientists find missing enzyme for tuberculosis iron scavenging pathway
6. Researchers report new pro-inflammatory role for anti-inflammatory enzyme
7. Purdue researchers use enzyme to clip DNA wires
8. Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
9. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
10. UCLA researchers identify key enzyme linked to childhood blindness
11. K-State professors discover enzyme responsible for creation of a beetles hard shell
Post Your Comments:
(Date:9/2/2014)... In the battle between our immune systems and ... bacteria-killing viruses known as phages. In a new study, ... Health, Haiti,s National Public Health Laboratory, and elsewhere, report ... their virulence in order to survive. Importantly, the study ... cholera,s mutational escape from phage predation occurs during human ...
(Date:9/2/2014)... the truth; everyone has a tipping point. We all want ... the benefit is great enough. Now, scientists have confirmed the ... , The result was published online this week in ... be honest, even if lying is beneficial," said Lusha Zhu, ... Virginia Tech Carilion Research Institute , where she works ...
(Date:9/2/2014)... Sam Kean stops by Reactions this week to debunk ... that, despite what "Shark Week" may lead you to ... http://youtu.be/KhFygIoW_MA . , Kean,s book, "The Disappearing Spoon: ... History of the World from the Periodic Table of ... 10-episode video series produced for the newly launched American ...
Breaking Biology News(10 mins):War between bacteria and phages benefits humans 2War between bacteria and phages benefits humans 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 2Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 4
... Single person submersibles have been called in to help ... that may hold vital clues to the history of life ... environmental geochemist in the Faculty of Science, says the objects ... microbialites because they are covered with microbes. Some of these ...
... risks from the use of nanomaterials will be explored ... project supported by a $400,000 grant from the U.S.Department ... Nanomaterials are becoming more prevalent in our lives each ... less than one one-thousandth the width of a human ...
... Canadell from CSIRO and the Global Carbon Project, and ... of tons of carbon dioxide (CO2) absorbed annually by ... change mitigation worth hundreds of billions of dollars. ... challenges in quantifying changes in the size of those ...
Cached Biology News:Mini subs to probe odd structures in BC lake 2Growing use of nanomaterials spurs research to investigate possible downsides 2Growing use of nanomaterials spurs research to investigate possible downsides 3Tropical forest sustainability: A climate change boon 2
(Date:9/2/2014)...  Synthetic Biologics, Inc. (NYSE MKT: SYN), a ... targeting specific pathogens that cause serious infections and ... preclinical toxicology study of SYN-004. Per U.S. Food ... was required to move the Company,s lead anti-infective, ... effects of Clostridium difficile (C. difficile), ...
(Date:9/2/2014)... -- Culot brings life science and software ... BioData, producer of Labguru, the web-based research ... appointment of Louis Culot as the company,s ... and Business Development at BioDiscovery Inc., developer of genomics ... Previously, Culot worked for 17 years with CambridgeSoft ...
(Date:9/1/2014)... The Collaborative R&D Terms and Agreements ... understanding and unprecedented access to the collaborative R&D ... leading life science companies. , The report provides ... why companies enter collaborative R&D deals. , Understanding ... terms provides critical insight into the negotiation process ...
(Date:8/31/2014)... 2014 This is a professional ... the Epoxy Hardener industry in Global and ... the industry, including definitions, applications and industry chain ... analysis are provided with a focus on history, ... A comparison between the international and Chinese situation ...
Breaking Biology Technology:Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5Louis Culot Appointed as BioData's CEO 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3
... , , , , , , ... , 1691112, 100 g, ... Inserts/Product , Instructions , , German , ... version - 54 K , , US Material Safety , Data Sheets, ...
... , , , Template , ... outcome of the PCR. For instance, , large amounts of RNA ... of the PCR. Also, impure templates may contain polymerase inhibitors that , ... always use a purification product specifically designed to purify DNA such , ...
... , , , PCR principles , , ... , , Setting up the , ... , , Thermal , Cycling ... Enzymes , Choice of RT-PCR Enzymes , , ...
Cached Biology Technology:PCR reaction components 2PCR reaction components 3PCR reaction components 4PCR reaction components 5PCR reaction components 6Roche Diagnostics Corporation 2
... ,Schistosomal glutathione-S-transferase (GST) is commonly ... proteins in E. coli (1). The GSTTag ... production and in some cases the solubility ... a soluble, properly folded form, GSTTag fusion ...
... peptide whose sequence is from the C-terminal end of the mouse retinoic ... amino acids 429 to 448 of RAR*. The sequence of PEP-005 ... - S - P - S - S - V - E ... - S - P - L - L - Q (The ...
... applications for the use of small interfering ... via the RNA interference (RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... or enzymatically, and then transfected into the ...
... The HybArray 12™ is an automated ... microarrays. The system automates both the hybridization ... onto glass slides. A single instrument can ... time in pairs and has multi-protocol software, ...
Biology Products: