Navigation Links
Targeted virus compels cancer cells to eat themselves

An engineered virus tracks down and infects the most common and deadly form of brain cancer and then kills tumor cells by forcing them to devour themselves, researchers at The University of Texas M. D. Anderson Cancer Center report this week in the Journal of the National Cancer Institute.

The modified adenovirus homed in on malignant glioma cells in mice and induced enough self-cannibalization among the cancer cells -- a process called autophagy -- to reduce tumor size and extend survival, says senior author Seiji Kondo, M.D., Ph.D., associate professor in the Department of Neurosurgery at M. D. Anderson.

''This virus uses telomerase, an enzyme found in 80 percent of brain tumors, as a target,'' Kondo says. ''Once the virus enters the cell, it needs telomerase to replicate. Normal brain tissue does not have telomerase, so this virus replicates only in cancer cells.''

Other cancers are telomerase-positive, and the researchers showed in lab experiments that the virus kills human prostate and human cervical cancer cells while sparing normal tissue.

In addition to demonstrating the therapeutic potential of the virus, called hTERT-Ad, Kondo says the international research team also clarified the mechanism by which such conditionally replicating adenoviruses (CRAs) infect and kill cancer cells.

Autophagy is a protective process that cells employ to consume part of themselves when nutrients are scarce or to destroy some of their organelles to recycle their components. A double membrane forms around the material to be consumed, then everything inside is digested.

Kondo and colleagues showed that hTERT-Ad (short for human telomerase reverse transcriptase promoter regulated adenovirus) infected the glioma cells and induced autophagy by inactivating a molecular pathway -- the mammalian target of rapamycin (mTOR) pathway -- that is known to prevent cellular self-cannibalization.

The result was a huge difference in t
'"/>

Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. Affymetrix and ParAllele Launch Industrys Most Comprehensive Product Line for Targeted Genotyping
2. Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
3. Association of herpesvirus with lung disorder questioned
4. Topical treatment shown to inhibit HIV and herpes simplex virus infection
5. Elusive HIV shape change revealed; Key clue to how virus infects cells
6. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
7. Live Recombinant Adenovirus Vaccine Technique Explored
8. Marburg virus disease in Angola - update
9. Studies reveal methods viruses use to sidestep immune system
10. Norovirus, AIDS vaccine and Hepatitis Virus
11. Epstein-Barr virus protein crucial to its role in blood cancers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Targeted virus compels cancer cells eat themselves

(Date:8/19/2014)... and Network-Level Science, , Imagine if we had the ... was responding to global changes in real time. Such ... multiple decades of information about ecological responses to environmental ... of different ecosystem types. , In fact, this ... Network, which will soon celebrate its 35th anniversary. , ...
(Date:8/19/2014)... Two Northwestern University scientists have identified a biomarker ... aggressive carcinoma that is resistant to many types ... provides a smart target for new therapeutics designed ... breast cancer patient data taken from The Cancer ... Robert W. Tell used powerful computational and bioinformatics ...
(Date:8/19/2014)... Texas Health Science Center at San Antonio and The ... the awarding of more than $750,000 in grants through ... , Launched in 2003, SALSI is a model of ... health science center join forces for greater research and ... with a focus on public health issues and diseases ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3San Antonio Life Sciences Institute awards $750,000 to innovators 2San Antonio Life Sciences Institute awards $750,000 to innovators 3
... effort led by The Burnham Institute's Gen-Sheng Feng has ... activity in the liver, and generated new findings about ... understanding the pathogenesis of type 2 diabetes. These results, ... made available to the scientific community by advance posting ...
... stem cell lines specifically tailored to match the nuclear DNA ... from disease or spinal cord injury. , The research is ... AAAS, the non-profit science society, on the Science Express website ... the study of human disease in cells in the laboratory. ...
... embryonic stem cell lines specifically tailored to match the nuclear ... suffering from disease or spinal cord injury. , The research ... by AAAS, the non-profit science society, on the Science Express ... enable the study of human disease in cells in the ...
Cached Biology News:Mouse with designer liver has enhanced glucose tolerance, insulin response 2Mouse with designer liver has enhanced glucose tolerance, insulin response 3SuperLigands - a database of ligand structures derived from the Protein Data Bank 2SuperLigands - a database of ligand structures derived from the Protein Data Bank 3SuperLigands - a database of ligand structures derived from the Protein Data Bank 4Scientists generate patient-specific stem cells, Science study says 2Scientists generate patient-specific stem cells, Science study says 3Scientists generate patient-specific stem cells, Science study says 4
(Date:8/19/2014)... Pa. , Aug. 19, 2014 A ... has been nominated for a Centers for Disease Control ... addressing a major public health concern. ... System, is one of a team of researchers nominated ... Charles C. Shepard Science Award for Data Methods and ...
(Date:8/19/2014)... Research and Markets  has announced the addition ... Strategic Business Report" report to their offering. ... Fuel Cells (SOFCs) in US$ Thousands. The report provides separate ... Europe , Asia-Pacific , ... for the period 2012 through 2020. Market data and analytics ...
(Date:8/19/2014)... XenoTech announces an exclusive partnership with ... from bioactive small molecules. Based on an ... convenient and timely assessment of critical metabolite and ... of Commercial Operations, Christian Darabant, “the value of ... be measured directly by comparison with the approximate ...
(Date:8/19/2014)... GLEN BURNIE, Md. , Aug. 19, 2014 /PRNewswire/ ... the clinical research industry, recently announced the formation of ... is pleased to announce the addition of Dr. ... Photo - http://photos.prnewswire.com/prnh/20140818/136957 ... insight across a variety of therapeutic areas and set ...
Breaking Biology Technology:Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3
... and economic development efforts here are taking shape with ... , ,The state is giving Wisconsin Indianhead Technical ... work with local businesses. With the grant, northern Wisconsin ... their workers in industrial maintenance, electrical, supervisory management, and ...
... for fishing enthusiasts may not guarantee you catching "the ... promising spots to cast a lure. , ,A newly ... topographical maps of about 1,000 Wisconsin lakes with global ... ideal fishing locations. The application requires only an Internet ...
... of this article is deliberately misleading. It feeds into ... a bunch of generational tribes engaged in rivalries and ... misunderstandings and tensions among workers born in different eras ... is overblown in my view. , ,Recently, I had ...
Cached Biology Technology:Superior receives funds for technical training 2Online fishing site introduces interactive maps 2Online fishing site introduces interactive maps 3Geezers, grungers, gen-Xers and geeks - a look at workplace generational conflict 2Geezers, grungers, gen-Xers and geeks - a look at workplace generational conflict 3Geezers, grungers, gen-Xers and geeks - a look at workplace generational conflict 4
... Chemicon Detergent-OUT Kit is a simple high ... solutions. Removes detergents without significant dilution ... protein solution on the Detergent-OUT Spin column ... columns are suitable for removing detergent from ...
... electrophoresis hood is a component ... Placed on the transilluminator, it ... and provides a darkroom environment ... lab bench. This 13 x ...
... Chemicon Detergent-OUT SDS Kit is a simple ... protein solutions. Removes detergents without significant ... the protein solution on the Detergent-OUT Spin ... Med columns are suitable for removing ...
... microarrays are derived from frozen embedded tissue ... control procedures to ensure the highest quality. ... in one block, sectioned at a thickness ... slides. Sections are large (3-5 mm in ...
Biology Products: