Navigation Links
Tandem transcripts team together

In the January issue of the journal Genome Research, two teams of scientists describe a widespread phenomenon in the human genome called transcription-induced chimerism (TIC), where two adjacent genes produce a single, fused RNA transcript. The work has implications for drug development, as well as for understanding mechanisms underlying gene evolution, transcription regulation, and genomic organization.

Dr. Roderic Guigó's group from the Centre de Regulació Genòmica (Barcelona, Spain), in collaboration with the group of Dr. Stylianos Antonarakis from the University of Geneva (Switzerland), and Dr. Rotem Sorek's team from Compugen (Tel Aviv, Israel) independently derived estimates that at least 2-5% of the genes in the human genome are involved in these events.

"In a certain way, this phenomenon challenges our very concept of a gene," points out Guigó. "The 'one gene, one protein' rule has been fundamental to molecular biology. However, as we deepen our understanding of the eukaryotic genome, a picture emerges that challenges this paradigm ?not a picture in which the sequences in the genome have distinct functions, but rather one in which the sequences participate in multiple transcripts, encoding molecules with diverse functionality."

Sorek's team systematically identified over 200 cases of TIC involving 421 human genes. They found that genes involved in TIC events often reside closer together than other gene pairs in the genome. In addition, they discovered that the intergenic sequences of TICs were processed via the same standard eukaryotic splicing machinery that removes introns from RNA transcripts.

Following a similar whole-genome survey of splicing events, Guigó's laboratory focused on the ENCODE regions, a set of DNA sequences, representing 1% of the genome, that have been chosen by a large research consortium for more rigorous, in-depth analyses. When focusing on these regions, the researchers identified six TIC e vents (involving 3.6% of tandem gene pairs), only one of which was identified during the whole-genome survey. This indicates that future investigations of specific regions may reveal a greater prevalence of TIC events genome-wide.

Sorek's team unraveled an interesting gene fusion event involving genes called PIP5K1A and PSD4, which reside side by side on human chromosome 1. These genes produce a fusion product that, during the course of evolution, inserted into a different location in the human genome (chromosome 10), becoming a new gene that is actively transcribed in a variety of tissues.

"Our findings might have applications in drug development," says Sorek. "Recombinant engineered fused proteins are currently being developed as therapeutic proteins by several companies and institutes. The problem is that these proteins often elicit an immune response and therefore, are toxic and cannot be used as efficient drugs. The understanding that some gene pairs are naturally produced as fused proteins might lead, in the future, to the development of non-toxic engineered fused proteins that could be used as drugs."


'"/>

Source:Cold Spring Harbor Laboratory


Related biology news :

1. Wild bees and the flowers they pollinate are disappearing together
2. MIT device draws cells close -- but not too close -- together
3. New molecular pathway could reveal how cells stick together
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2017)... Jan. 4, 2017  For the thousands of attendees at this year,s ... in connected health and biometric measurement devices and services, will be featuring ... On display in A&D Medical,s special CES Exhibit Suite , the ... expansion of the company,s WellnessConnected product platform.  ... ...
(Date:1/3/2017)... VEGAS , Jan. 3, 2017 Onitor, ... the introduction of Onitor Track, an innovative biometric data-driven ... men, showcasing this month at the 2017 Consumer Electronics ... In the U.S., the World Health ... more than two-thirds of adults who are overweight or ...
(Date:12/22/2016)... , December 22, 2016 SuperCom (NASDAQ: ... secure solutions for the e-Government, Public Safety, HealthCare, and Finance sectors ... SuperCom, has been selected to implement and deploy a community-based supportive ... Northern California , further expanding its presence in the ... This new ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... Jan. 24, 2017  Neogen Corporation (NASDAQ: ... agreement with SenesTech Incorporated (NASDAQ: SNES ) ... being developed by SenesTech. The two firms had worked ... the SenesTech product was approved by the U.S. Environmental ... that the product could only be used by a ...
(Date:1/24/2017)... 24, 2017  Bruker today announced that ... leader in the development, manufacture, and sale ... Hysitron,s innovative nanomechanical testing instruments to Bruker,s ... surface profilometers, and tribology and mechanical testing ... nanomaterials research markets. Hysitron,s 2016 revenues were ...
(Date:1/24/2017)... , ... January 24, 2017 , ... ... label-free graphene biosensor assays for fragment-based screening, will showcase its proprietary ... Society for Laboratory Automation and Screening (SLAS) conference in Washington, D.C. from Feb. ...
(Date:1/24/2017)... ... 2017 , ... Edward Buckler, Ph.D., a research geneticist focused ... of Sciences Prize in Food and Agriculture Sciences. He is being honored for ... of Sciences (NAS) Prize in Food and Agriculture Sciences was established in 2016 ...
Breaking Biology Technology: