Navigation Links
Tamoxifen for breast cancer prevention does not benefit most women

develop an estrogen receptor-negative tumor, which has a worse prognosis. (Cancers prevented by tamoxifen are mostly estrogen receptor-positive).

In the new study, Melnikow and her colleagues calculate that tamoxifen can be expected to extend life expectancy only when a woman's five-year risk of developing breast cancer reaches 3 percent or more. This is especially true for women who have not had a hysterectomy, and therefore face the risk of endometrial cancer related to tamoxifen use.

Cost-effectiveness was also calculated in the study. For women at the 1.67-percent risk level, taking tamoxifen to stave off breast cancer came to $1.3 million per year of life saved based on the U.S. price of the drug -- a prohibitively expensive cancer-prevention strategy. Melnikow and her co-authors note, however, that the cost-effectiveness equation could be improved if pharmaceutical prices were negotiated at a national level. At Canadian prices, for example, the researchers showed that taking tamoxifen to prevent breast cancer comes to $123,780 per year of life saved for women at the 1.67-percent risk level.

In comparison, annual flu shots cost about $980 per year of life saved for patients ages 65 and older; colonoscopy every 10 years costs about $11,000 per year of life saved for people 50 and older; and annual mammography costs about $58,000 per year of life saved for women ages 40 to 80.

To arrive at their findings, Melnikow and her colleagues used a complex mathematical model based on a hypothetical group of 50-year-old women.

Melnikow specializes in research to better understand women's health-care preferences and how women make health-care decisions. In a study published in the journal Cancer last year, she reported that among women with a five-year breast cancer risk of 1.67 percent or higher, fewer than one in five were inclined to take tamoxifen to prevent the disease. Concern about potential side effects was the primar
'"/>

Source:University of California - Davis


Page: 1 2 3

Related biology news :

1. Tamoxifen-like drug suggests new ways to selectively block estrogen
2. Viral DNA sequence a possible trigger for breast cancer
3. Used in a new way, RNA interference permanently silences key breast cancer gene
4. Biomarkers isolated from saliva successfully predict oral and breast cancer
5. Study reveals dramatic difference between breast cancers in US and Africa
6. Compounds in plastic packaging act as environmental estrogens altering breast genes
7. Alcohol consumption disrupts breastfeeding hormones
8. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
9. Scientists discover genetic pathway responsible for breast cancer cell growth
10. Study hints at role of stem cell genes in testicular, breast cancers
11. Microarray technology for tailoring breast cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen for breast cancer prevention does not benefit most women

(Date:7/21/2014)... ROUGE LSU,s Mark Batzer, Boyd Professor and Dr. ... Sciences in the College of Science, contributed to an ... titled "The Common Marmoset Genome Provides Insight into Primate ... Batzer contributed analysis of "jumping genes," or mobile elements ... mechanism in the genome. The marmoset is important because ...
(Date:7/21/2014)... Dr. Mark DeCoster, the James E. Wyche III ... University, will present as an invited speaker at ... Biopolis Research and Development Center in Singapore. , ... in Louisiana Tech,s Institute for Micromanufacturing, will present ... 3D cell and tissue models." The presentation ...
(Date:7/21/2014)... many times do we see an innovation and think, ... minds start turning towards thoughts of our own invention, ... is the concept behind the International Space Station Program ... see what their colleagues have going on in orbit, ... "Our goal is to encourage investigators to propose new ...
Breaking Biology News(10 mins):LSU's Mark Batzer contributes to Nature Genetics article on marmoset genome 2Louisiana Tech University professor presents at International Bioprinting Congress 2International Space Station researcher guides aim to maximize science 2International Space Station researcher guides aim to maximize science 3International Space Station researcher guides aim to maximize science 4
... 2008) Self-guided treatment for depression could soon ... Scientists with the National Space Biomedical Research Institute ... will assist astronauts in recognizing and effectively managing ... a substantial threat to crew safety and mission ...
... diet that contains enough essential vitamins and minerals. ... nutritional status has shown that the average child gets the ... consume more added sugars than recommended. The study ... looked at a nationally representative sample of children aged 4-18 ...
... scientific researchers released two new studies today, including a ... cause significant impacts on Florida,s coastlines and economy due ... researchers at Florida Atlantic University recommends that the state ... at adapting to these large coastal and other impacts ...
Cached Biology News:Coming soon: Self-guided, computer-based depression treatment 2Coming soon: Self-guided, computer-based depression treatment 3Variety of foods -- the key for child nutrition 2New studies find global warming will have significant economic impacts on Florida coasts 2New studies find global warming will have significant economic impacts on Florida coasts 3
(Date:7/22/2014)... Jersey , 22. Juli 2014 ... Life-Sciences-Industrie, hat die Ernennung von Marcus Bergler zum ... Herr Bergler hat die europäischen kommerziellen Aktivitäten von ... Bevor er sich Qforma anschloss, war er in ... Customer Information, als Vertriebsteam-Leiter Deutschland bei IMS Health ...
(Date:7/21/2014)... July 21, 2014 Lawrence ... Investment Board (WIB) and Las Positas College (LPC) ... technical education and hands-on training for veterans, officials ... Program at Las Positas is designed to ... for engineering technician careers, and establishes a pipeline ...
(Date:7/21/2014)... EUGENE, Ore. (July 21, 2014) The yield ... of Oregon have developed a low-energy, solution-based mineral substitution ... that could find use in electronics and alternative energy ... on the cover of the July 21 issue of ... most citations of research in the inorganic and nuclear ...
(Date:7/20/2014)... the process releases radioactive krypton and xenon gases. Naturally ... gas radon. A new porous material called CC3 effectively ... Nature Materials shows how: by breathing enough ... , The CC3 material could be helpful in removing ... air in buildings and also in recycling useful elements ...
Breaking Biology Technology:Qforma gibt Schaffung des neuen Postens als General Manager in Europa bekannt 2Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3Oregon chemists eye improved thin films with metal substitution 2A noble gas cage 2A noble gas cage 3
... - With the U.S. economy showing alternating signs of ... to business organizations that might want to slow the ... a housing-induced recession. , ,The Information Technology and ... the Economic Benefits of the Information Technology Revolution, focused ...
... Wis. - The Fitchburg Plan Commission has recommended approval ... building and data center that would accommodate the expansion of ... the anchor tenant in both buildings, which are planned for ... Fitchburg Technology Campus . , ,The plans, which now go ...
... has its own lingo. Whether it be at play (like ... lawyers, education, military), it seems that when a group of ... outside of the group can understand. The world of ... I continue in the series that I began with the ...
Cached Biology Technology:Study affirms information technology-productivity link 2Study affirms information technology-productivity link 3Berbee to expand at New Venture Center 2Translating the language of capital-raising 2Translating the language of capital-raising 3Translating the language of capital-raising 4Translating the language of capital-raising 5Translating the language of capital-raising 6Translating the language of capital-raising 7
... Preparation contains a unique β-agarose digesting enzyme ... of intact DNA and RNA from low ... in TAE, TBE, MOPS, or phosphate buffers. ... the TAE, TBE, MOPS, and phosphate electrophoresis ...
... Preparation contains a unique β-agarose digesting enzyme ... of intact DNA and RNA from low ... in TAE, TBE, MOPS, or phosphate buffers. ... the TAE, TBE, MOPS, and phosphate electrophoresis ...
... causing shortages in your laboratory or fellow ... cause unwanted distractions, problems and delays. • ... hard work and endeavour! Bring us your ... and market it internationally. We work under ...
... in-house demand is causing shortages in your ... This can cause unwanted distractions, problems and ... royalties for your hard work and endeavour! ... build it up,and market it internationally. We ...
Biology Products: