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Taking the wrinkles out of motoneuronal disease

A winner of UniQuest's 2006 Trailblazer innovation competition, Dr Frederic Meunier, is developing a treatment for motoneuronal diseases based on modifying botox –the popular anti-wrinkle treatment.

Motoneuronal diseases cause a degeneration of the nerve pathways controlling muscle activity. The diseases are severe and physically debilitating disorders which lead toprogressive weakness and wasting of muscles. Many of the diseases are incurable.

Dr Meunier is developing botox to selectively deliver drugs to motoneurons to directly treatmotorneuron diseases.

"I first became interested in investigating neurotoxins because they are fantastic moleculartools to dissect synaptic mechanisms," Dr Meunier said.

"The aim of our lab is to understand the molecular mechanism underlying neuronal communication. The legacy of millions of years of evolution and competition between venomous species has resulted in deadly neurotoxins capable of blocking neuronal communication. I am using our knowledge of the mode of action of these neurotoxins to design a selective motoneuron delivery system that could change our way of treating motoneuronal diseases."

Dr Meunier's innovative research caught the attention of UQ's main commercialisation company, UniQuest Pty Ltd, which runs the annual Trailblazer competition.

UniQuest Managing Director David Henderson said the Trailblazer judges were impressed by Dr Meunier's research and the opportunities surrounding it.

"The therapeutic applications of this research are important, as it could help prevent or cure motoneuronal diseases," Mr Henderson said.

"Also, the research potentially has important applications for the treatment of other diseases."


Source:Research Australia

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