Navigation Links
Taking 'chips' to the next level of gene hunting

Researchers at the Johns Hopkins' High Throughput Biology Center have invented two new gene "chip" technologies that can be used to help identify otherwise elusive disease-causing mutations in the 97 percent of the genome long believed to be "junk."

A variety of DNA microarray technology, one of the two new chips, called the TIP-chip (transposable element insertion point) can locate in the genome where so-called jumping genes have landed and disrupted normal gene function. This chip is described online this week in the Proceedings of the National Academy of Sciences.

The most commonly used gene chips are glass slides that have arrayed on them neat grids of tiny dots containing small sequences of only hand-selected non-junk DNA. TIP-chips contain on them all DNA sequences. Because each chip can hold thousands of these dots - even a whole genome's worth of information - scientists in the future may be able to rapidly and efficiently identify, by comparing a DNA sample from a patient with the DNA on the chip, exactly where mutations lie.

"With standard chips, we're missing a big piece of the picture of mutations in humans because they look only at the meaty parts of genes, but the human genome is only 3 percent meaty parts," says Jef Boeke, Ph.D., Sc.D, professor of molecular biology and genetics and director of the HiT (High Throughput Biology Center), who spearheaded both studies at the Institute of Basic Biomedical Sciences at Hopkins. "The other 97 percent also can contain disease-causing mutations and is often systematically ignored," he says.

Boeke and his team have focused particularly on transposable elements, segments of DNA that hop around from chromosome to chromosome. These elements can, depending on where they land, wrongly turn on or off nearby genes, interrupt a gene by lodging in the middle of it, or cause chromosomes to break. Transposable elements long have been suspected of playing a role vital to disease-causing
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
2. Taking Aim With Nanoparticle PEBBLEs
3. Taking the piste out of Alpine vegetation
4. Taking a flying jump
5. Taking a bite out of a fellow worker helps wasps recruit new foragers
6. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
7. Taking the wrinkles out of motoneuronal disease
8. Cancer vaccines -- Taking a jab at cancer by stimulating the immune system
9. Unprecedented water level rise in Somalia
10. Low level of extinction during ice age linked to adaptability
11. New lab technique identifies high levels of pathogens in therapy pool
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Taking chips the next level gene hunting

(Date:7/13/2014)... research raises the prospect of more effective treatments for ... in about half of all cancer patients, raising their ... Institute. , Many strategies have been tried to reverse ... can,t endure potentially life-saving treatments, but none have had ... advanced online edition of Nature , led by ...
(Date:7/11/2014)... Society for Bone and Mineral Research awarded Michael F. ... (BUSM), with the 2014 Louis V. Avioli Award. Holick, ... is internationally known for revolutionizing the understanding of vitamin ... The award honors a member of the American Society ... to bone and mineral basic research. It is named ...
(Date:7/11/2014)... of researchers from The Chinese University of Hong Kong, ... wild soybean linked to salt tolerance, with implication for ... This study published online in Nature Communications ... for crop improvement. , Soybean is an important crop ... cultivated soybeans have less genetic diversities than their wild ...
Breaking Biology News(10 mins):Antibody halts cancer-related wasting condition 2Antibody halts cancer-related wasting condition 3BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2BGI reports a novel gene for salt tolerance found in wild soybean 2
... for their lethal bites, but not all. Some spit defensively. ... some cobras defend themselves by spraying debilitating venom into the ... spitting cobras in South Africa, Young took the opportunity to ... by a sheet of Perspex, Young caught the trails of ...
... , NAIROBI, KENYA (MAY 13, 2010) The Wildlife Conservation ... closures and gear restrictions implemented in fishing areas can ... presented today at the Subsidiary Body on Scientific, Technical, ... held in Nairobi, Kenya, will help usher in a ...
... Nutrition, Agriculture, and Natural Resource Sciences in the FY ... written by key staff at American Society of Agronomy, ... of America. Authors Karl Glasener, Director of ... Coordinator, highlight programs and trends across the federal portfolio ...
Cached Biology News:Spitting cobras track first, predict later 2Not a fish story: Protected corals increase fishing profits 2Not a fish story: Protected corals increase fishing profits 3Identifying federal research dollars for ag 2
(Date:7/11/2014)... -- Research and Markets  has announced the addition ... Industry Analysis, Size, Share, Growth, Trends and Forecast to ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection is a ... RNA) into cells. This technology helps the cells to ... metabolism by affecting the nuclear genes. The transfection technology ...
(Date:7/11/2014)... AZ (PRWEB) July 11, 2014 ... device company specializing in the soft tissue reconstruction ... All-Suture Anchor System for surgeries involving the shoulder ... fixation through a novel, inserter-controlled deployment method. The ... to partial deployment, anchor pull-out, or anchor displacement ...
(Date:7/10/2014)... Mass. (PRWEB) July 10, 2014 Terascala, ... today announced that Alan Swahn, a former vice president ... executive team as vice president of marketing. Terascala’s software ... Dell and NetApp create the highest performance and most ... been appointed to guide Terascala’s channel expansion and broaden ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Senior ... institutions and professional associations, addressed the challenges of “Reducing ... Medical Device Industries” through strategic sourcing. Describing the partnership ... with the Supply Chain Management Institute ( SCMI) ... event on June 24 at the Kroc Institute of ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Terascala Expands Executive Team 2Terascala Expands Executive Team 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4
... BEER-SHEVA, ISRAEL, February, 18 2011 Ben-Gurion University of ... that stabilizes an otherwise unstable form of calcium carbonate. ... retention rates than other sources presently used as dietary ... one of the most important minerals in the human ...
... 18, 2011 Palatin Technologies, Inc. (NYSE Amex: ... February 24, 2011 at 11:00 a.m. Eastern Time to discuss ... for its programs under development.   Schedule ... Q2 Fiscal Year 2011 Conference Call-Live Domestic Dial-In ...
... the University of Pittsburgh have been awarded funding for two ... spinal cord injuries to test if it is possible for ... or a prosthetic limb, with their thoughts. The projects ... the interfaces temporarily placed on their brains and were able ...
Cached Biology Technology:New Pitt projects will test brain computer interfaces for people with spinal cord injury 2
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... 2 NaO 7 S 2 Formula Weight: ... Identity: By IR epsilon max (615 nm, ... equal to 60 x 10 3 Loss ... lambda max (H 2 O solution): ...
...
... research-grade spectrofluorometer with a minimum 1 nm ... 200 or greater for the Raman band ... to keep in mind in order to ... titration, or anisotropic measurements. ,The FP-6500 is ...
Biology Products: