Navigation Links
TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

lymphoma by enlarging the B lymphocyte population. This increases the likelihood that at least a few of the cells acquire a mutation eliminating p53 function just by chance. In the absence of p53, the cells remains alive and become cancerous."

The study's findings help explain the interlocking roles of MYC, TEL2, and p53 in the development of B lymphoma. It was already known that many human B-cell lymphomas over-express the MYC gene, either because the tumor cells acquire additional copies of this gene or because the cells suffer mutations that affect control over the level of MYC expression. Excess MYC expression spurs the cells to proliferate. This abnormal behavior then triggers p53 to instruct these overzealous cells to undergo apoptosis.

However, such rogue cells can still become fully cancerous if they succeed in eliminating p53 activity, in effect silencing the command to commit suicide. This situation occurs when increased TEL2 activity reduces the cell's ability to trigger apoptosis in response to relentless prodding by MYC to keep multiplying. As the process of apoptosis becomes sluggish, the population of B lymphocytes increases. The greater the number of these cells, the more likely some of them will eliminate their p53 function. Without the ability to commit suicide, these cells will start multiplying entirely out of control.

"This is exactly what we saw in mice that were genetically modified so their B lymphocytes were over-expressing MYC," Grosveld said. "When we forced over-expression of TEL2 in these mice, we curtailed apoptosis in the precancerous B lymphocytes that were being forced to multiply by MYC."

But even the combined effect of MYC and TEL2 wasn't enough to turn these overactive lymphocytes into lymphoma cells.

"The coup de grace consisted of a complete elimination of the apoptotic response through loss of p53 function," Grosveld said. "In fact, all TEL2/MYC B-cell lymphomas had lost their p53 functio
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3

Related biology news :

1. H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses
2. Finnish scientists discovered a new approach to treat virus-induced lymphomas
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: TEL2 gene cooperates with MYC gene provoke cell lymphomas

(Date:5/20/2013)... effect of physical education (PE) on child weight, but ... the amount of time that elementary schoolchildren spent in ... study represents some of the first evidence of a ... forthcoming in the Journal of Health Economics . ... be viewed at: http://www.sciencedirect.com/science/article/pii/S0167629613000556 , The research ...
(Date:5/20/2013)... National Science Foundation (NSF) planning grant will help establish ... joint program of the University of Illinois at Urbana-Champaign ... "CARD will be devoted to research in drying moist, ... forestry and paper products; chemical products; textiles; and biopharmaceuticals," ... food science and human nutrition and the Illinois site ...
(Date:5/20/2013)... articles posted online ahead of print 9 ... of geoscience subdisciplines, including minerals exploration, archaeology, planetary ... include Siberia; the Sumatran subduction margin; the Monte ... and the Southeastern U.S. Atlantic Margin. Brief highlights ... tectonics;, 2. The clear fingerprint of ice ages ...
Breaking Biology News(10 mins):Gym class reduces probability of obesity, study finds for first time 2NSF approves planning grant for Center for Advanced Research in Drying 2New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 2New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 3New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 4New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 5New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 6New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 7New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 8New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 9New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 10New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 11
... deliver payloads of cancer-fighting drugs to tumors in the ... But scientists are still at a relatively early stage ... Although developing nanoparticles that work as "magic bullets" ... is still the goal, the reality is that most ...
... MARC (Minority Access to Research Careers) Program has announced ... of America (GSA) Mouse Genetics conference in Washington, DC ... to promote the entry of underrepresented minority students, postdoctorates ... community and to encourage the participation of young scientists ...
... Royal Swedish Academy of Sciences, Margareta is the editor of ... changes we see are dramatic. And they are not coincidental. ... compared with a longer term perspective", she says. The ... is warming up fastest today. Measurements of air temperature show ...
Cached Biology News:Hitting target in cancer fight now easier with new nanoparticle platform, UCLA scientists say 2A new research report shows effects of climate change in the Arctic are more extensive than expected 2A new research report shows effects of climate change in the Arctic are more extensive than expected 3
(Date:5/20/2013)... May 20, 2013  (PSHR) Pacific Shore Holdings, ... products across a broad range of product categories ... investor relations firm, BlueWater Advisory Group, to provide ... trading process, and to direct the company,s outreach ... Matthew Mills , Pacific ...
(Date:5/20/2013)... NY (PRWEB) May 20, 2013 With bed ... Products said that although bed bugs need to be eliminated, ... will not compromise a person's health. And so to help ... how to get rid of bed bugs without ... non-pesticide bed bug spray it called Bed Bug Bully. , ...
(Date:5/20/2013)... --  Flexion Therapeutics , Inc. today announced the addition ... its management team as chief financial officer. Mr. Driscoll ... with biotechnology and medical device companies. Prior ... for Novavax (NASDAQ: NVAX ) where he ... through a combination of investment funding and commercial and ...
(Date:5/20/2013)... 2013 Researchers from the Southern University ... lower back pain, and the acne causing P.acnes bacteria. Researchers ... the bacteria seek out oxygen deprived location to seek shelter ... column, P.acnes has the ability to live in the open ... a spokesman for “ The best acne treatment ” explains ...
Breaking Biology Technology:Pacific Shore Holdings Retains Investor Relations Firm 2New Non Pesticide Discovery on How to Get Rid of Bed Bugs Tipped by My Cleaning Products 2Flexion Therapeutics Names Frederick Driscoll Chief Financial Officer 2Adult Acne Treatment, Probiotic Action Shares New Insight How Treating Acne May Help Reduce Body Pain 2
... highly efficient and fast PCR amplification ... in a ... Biosystems, Inc., a leading,developer of state-of-the-art PCR devices and Cell-based ... at the San,Diego Convention Center that it has successfully completed ...
... 17 BioXcel Corporation,today announced a strategic ... leading consulting company serving the healthcare industry., ... will combine forces with,ASDO,s industry-experienced consultants to ... analytics to support,licensing/due-diligence, competitive intelligence, IP analytics, ...
... 17 Campbell Alliance, the leading,management consulting firm ... that its Clinical Development Practice will,conduct two workshops ... to be held June 22 to 26, 2008, ... Dietlin, Vice President, will lead a workshop that ...
Cached Biology Technology:Ahram Biosystems Completes Development of a Palm-Size Portable PCR Device 2BioXcel Expands Its Capability in Business Analytics Support Services 2Campbell Alliance Clinical Development Practice to Conduct Two Workshops at 44th DIA Annual Meeting 2Campbell Alliance Clinical Development Practice to Conduct Two Workshops at 44th DIA Annual Meeting 3Campbell Alliance Clinical Development Practice to Conduct Two Workshops at 44th DIA Annual Meeting 4
Rabbit polyclonal to ErbB 2 (phospho Y1248) ( Abpromise for all tested applications). entrezGeneID: 2064 SwissProtID: P04626...
...
... Blot Strong Antibody Stripping Solution is effective ... that have been developed with chemiluminescence or ... not recommended for stripping colorimetric substrates (TMB, ... possible to effectively remove substrates that precipitate ...
... supplied as a 5x solution. Designed ... membrane-bound proteins without destroying antigenic binding ... radioisotopic signals from blots. Not recommended ... as a 5X solution sufficient to ...
Biology Products: