Navigation Links
TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

The genes TEL2 and MYC cooperate with each other to promote pediatric cases of the immune system cancer B-cell lymphoma. This finding, from investigators at St. Jude Children's Research Hospital, is published in the current issue of Molecular Cell Biology (MCB).

B-cell lymphoma is a cancer in which the antibody-producing cells (B lymphocytes) multiply uncontrollably and crowd out other blood cells. The St. Jude researchers report that TEL2 cooperates with MYC to increase the chance that a certain mutation will occur in precancerous B lymphocytes, permitting these cells to become cancerous. This mutation inactivates the function of p53, a gene that orchestrates the ability of abnormal lymphocytes to commit suicide--ridding the body of potentially cancerous cells.

"The study's findings strongly suggest that physicians should look for TEL2 activity in a patient's B-cells as part of the diagnosis of B-cell lymphoma," said Gerard Grosveld, Ph.D., chair of St. Jude Genetics and Tumor Cell Biology. "TEL2 should also be considered a potential target for novel drugs to treat this disease." Grosveld is senior author of the MCB report.

The TEL2 gene is part of a family of genes called ETS transcription factors. Transcription factors prompt the cell to read the code of a specific gene and produce copies of RNA. RNA then directs the production of the protein that the gene codes for. The gene TEL1, which works to slow cell growth and multiplication, is another member of the ETS family and is a known target of mutations in human leukemia. Grosveld's group previously identified TEL2 and noted its similarity to TEL1, which prompted them to investigate whether TEL2 also played a role in leukemia. In the MCB study, the investigators discovered that, unlike TEL1, TEL2 promotes cell multiplication, playing an indirect role in the development of B lymphoma.

"TEL2 doesn't directly cause cancer," Grosveld said. "Instead, this gene promotes the development of
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3

Related biology news :

1. H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses
2. Finnish scientists discovered a new approach to treat virus-induced lymphomas
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: TEL2 gene cooperates with MYC gene provoke cell lymphomas

(Date:8/19/2014)... biology and other science courses are increasingly being ... now they have a new textbook to help ... published this month by Princeton Press and co-authored ... and Biological Synthesis (NIMBioS), teaches readers about basic ... to explore and explain biological phenomena. , Suitable ...
(Date:8/19/2014)... awarded a nearly $40,000 grant from the National Center ... the National Park Service (NPS) and U.S. Department of ... of the energy efficiency and cost effectiveness of radiant ... , Radiant barriers are reflective thermal insulations commonly fitted ... reducing the amount of heat emitted in the direction ...
(Date:8/19/2014)... are superior to humans and animals in a number ... which enables them to regrow entire organs. After being ... back its entire crown. But there is one major ... literally rooted to the habitats in which they live ... In response to this dilemma, plants have developed mechanisms ...
Breaking Biology News(10 mins):New textbook introduces undergraduates to mathematics for the life sciences 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3How steroid hormones enable plants to grow 2
... has been heading north since it was first introduced from ... invader chokes out native species and has dramatically altered wetland ... have a vulnerability after all: the northern climate. Canadian ... carries a severe reproductive penalty that may limit its spread. ...
... Mich. A team of Michigan State University scientists ... have uncovered the inner workings of a key iron-containing ... medicines or understand how enzymes repair DNA. ... that is important in metabolism. Enzymes in this family ...
... ... ... , ... , , , ...
Cached Biology News:Climate may keep beautiful killer plant in check 2MSU scientists unlock key enzyme using newly created 'cool' method 2ModiFace Launches iLab: An iPhone and iPad App Experimentation Laboratory 2ModiFace Launches iLab: An iPhone and iPad App Experimentation Laboratory 3
(Date:8/19/2014)... One of the major limitations ... inadequate vascular supply. Nutrient and gas transport throughout ... critical for successful regeneration and integration into the ... in vascularization and promote angiogenesis in a variety ... design and architecture, and enhancing scaffolds with stem ...
(Date:8/19/2014)... Calif. (PRWEB) August 19, 2014 ... campaign to raise $200,000 to fund a corporate ... device. , This development is a critical ... model of care to the implementation of personalized ... method of practicing medicine. , Indiegogo contributions will ...
(Date:8/19/2014)... 19, 2014 Research and ... the "Spectroscopy Equipment and Accessories - ... their offering. This report ... and Accessories in US$ Thousands by the ... Raman Spectrometers, NMR-EPR Spectrometers, Near Infrared (NIR) ...
(Date:8/19/2014)... , Aug. 19, 2014 /PRNewswire/ - iCo Therapeutics ... ICOTF), today reported results of its Oral Amphotericin ... HIV reservoirs.  The study, conducted by ImmuneCarta®, the ... in vitro effectiveness of Oral Amp B ... present in individuals despite intensive treatment with antiretroviral ...
Breaking Biology Technology:Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3
... University in Sendai, Japan, has purchased a LEAP 3000 metrology ... of Madison, Wis. The Tohoku University system is ... six months. Imago delivered the system in conjunction with its representatives ... removing and examining individual atoms, enabling metrology at the atomic scale. ...
... National Science Foundation -funded network, University of Wisconsin-Madison engineering ... nation's top science museums to create hands-on exhibits about technology ... it. , ,The Museum of Science , Boston, the ... , San Francisco, are leading the $20 million Nanoscale Informal ...
... adoption curves, just take a look at the data from ... that business blogging isnt just about to take off ... 55% of corporations have adopted blogs for both internal ... organizations launched their blogs within the last year, and most ...
Cached Biology Technology:Engineers help turn science into interactive exhibits 2Staggering stats on blog adoption 2Staggering stats on blog adoption 3
Rabbit polyclonal to SpUlp2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: SNNERQSLSSGSND, corresponding to amino acids 622-635 of Schizosaccharomyces pombe SpUlp2...
Rabbit polyclonal to Factor IX ( Abpromise for all tested applications). entrezGeneID: 2158 SwissProtID: P00740...
Mouse monoclonal [CLB-SW16 (formerly 708)] to CD42d (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 2814 SwissProtID: P40197...
ANTI-HUMAN CYTOKINES, GROWTH FACTORS (polyclonal rabbit (or goat) antibodies) Human TARC - Biotin...
Biology Products: