Navigation Links
TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

The genes TEL2 and MYC cooperate with each other to promote pediatric cases of the immune system cancer B-cell lymphoma. This finding, from investigators at St. Jude Children's Research Hospital, is published in the current issue of Molecular Cell Biology (MCB).

B-cell lymphoma is a cancer in which the antibody-producing cells (B lymphocytes) multiply uncontrollably and crowd out other blood cells. The St. Jude researchers report that TEL2 cooperates with MYC to increase the chance that a certain mutation will occur in precancerous B lymphocytes, permitting these cells to become cancerous. This mutation inactivates the function of p53, a gene that orchestrates the ability of abnormal lymphocytes to commit suicide--ridding the body of potentially cancerous cells.

"The study's findings strongly suggest that physicians should look for TEL2 activity in a patient's B-cells as part of the diagnosis of B-cell lymphoma," said Gerard Grosveld, Ph.D., chair of St. Jude Genetics and Tumor Cell Biology. "TEL2 should also be considered a potential target for novel drugs to treat this disease." Grosveld is senior author of the MCB report.

The TEL2 gene is part of a family of genes called ETS transcription factors. Transcription factors prompt the cell to read the code of a specific gene and produce copies of RNA. RNA then directs the production of the protein that the gene codes for. The gene TEL1, which works to slow cell growth and multiplication, is another member of the ETS family and is a known target of mutations in human leukemia. Grosveld's group previously identified TEL2 and noted its similarity to TEL1, which prompted them to investigate whether TEL2 also played a role in leukemia. In the MCB study, the investigators discovered that, unlike TEL1, TEL2 promotes cell multiplication, playing an indirect role in the development of B lymphoma.

"TEL2 doesn't directly cause cancer," Grosveld said. "Instead, this gene promotes the development of
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3

Related biology news :

1. H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses
2. Finnish scientists discovered a new approach to treat virus-induced lymphomas
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: TEL2 gene cooperates with MYC gene provoke cell lymphomas

(Date:3/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) ... Global Strategic Business Report" report to their offering. ... in US$ Thousands. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided ...
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ... - Global Strategic Business Report" report to their offering. ... Biometrics in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Latin America . Annual estimates ...
(Date:3/18/2015)... -- As mobile payments become more prevalent amongst ... apps continue to be introduced into the market place at ... industry in focus today are:  NXT-ID, Inc. (NASDAQ: ... ), Apple Inc. (NASDAQ: AAPL ), Google Inc. ... FB ) NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
... with businesses in Munich, Germany and Ann Arbor, Michigan ... at the National Institute on Aging, National Institutes of ... stem (ES) cells. , In their work they first ... and qRT-PCR methods. Then they employed extensive DNA promoter ...
... the media agree that prolonged jogging raises people,s spirits. ... called endorphins, are the cause of this. But in ... at the Technische Universitt Mnchen and the University of ... driven runners high. In an imaging study they were ...
... Attempting U.S. ... Entry, ... the U.S. Department of Homeland Security (DHS) is,expanding the operation of their ... charged with securing the more than 95,000 miles of,America,s coastline," said Rear ...
Cached Biology News:The myth of runner's high revisited with brain imaging 2The myth of runner's high revisited with brain imaging 3DHS Expands Biometrics-at-Sea Program to the Florida Straits 2
(Date:5/4/2015)... , May 4, 2015   Intrexon Corporation ... first quarter 2015 financial results after the market closes ... conference call that day at 5:30 PM ET to ... The conference call may be accessed by ... to join the "Intrexon Conference Call."  Participants may also ...
(Date:5/4/2015)... Marianjoy Rehabilitation Hospital has ... hand impairments by acquiring the Armeo®Spring arm and ... site. , Secured through grant support of a ... option for patients with upper extremity weakness or ... of just four Illinois providers offering treatment with ...
(Date:5/1/2015)... N.C. (PRWEB) May 01, 2015 ... Charlotte (UNC Charlotte) spin-out company, announced that Pinku Mukherjee, ... the UNC Board of Governors’ highest faculty honor. ... to humanity’s welfare , for her innovative research and ... Max Gardner Award represents a crowning moment in my ...
(Date:5/1/2015)... 2015 Pfenex Inc. (NYSE MKT: PFNX), ... of biosimilar therapeutics including high value and difficult ... quarter 2015 financial results will be released on ... market. At 8:30 am Eastern Time, Pfenex management will ... results and provide a business update. A press release ...
Breaking Biology Technology:Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2
... ATLANTA, March 24 GeoVax Labs, Inc. (OTC,Bulletin Board: ... company, is very pleased to announce the addition of ... 2008. Current President/CEO,and company co-founder Don Hildebrand remains as ... to be heavily involved in company,development, growth and expansion ...
... An information technology,revolution is improving cancer ... according to Supportive Oncology Services, Inc. (SOS), ... PROs are self-,assessments that measure any aspect ... the patient without any interpretation by the ...
... be Used as Biomarkers, for Diagnosing the Primary Tumor Site in Patients With ... ... That Will be the Basis of a CUP Diagnostic Test That Will be ... by a CLIA-certified lab in the US in 2008, Approximately 70,000 Patients in ...
Cached Biology Technology:GeoVax Further Strengthens Management Team 2GeoVax Further Strengthens Management Team 3GeoVax Further Strengthens Management Team 4GeoVax Further Strengthens Management Team 5Patient-Reported Outcomes (PROs) Improve Cancer Treatment -- Experts Agree 2Patient-Reported Outcomes (PROs) Improve Cancer Treatment -- Experts Agree 3Accurate Identification of Tumor Origin Using MicroRNAs is Published by Rosetta Genomics' Scientists and Collaborators in Nature Biotechnology 2Accurate Identification of Tumor Origin Using MicroRNAs is Published by Rosetta Genomics' Scientists and Collaborators in Nature Biotechnology 3Accurate Identification of Tumor Origin Using MicroRNAs is Published by Rosetta Genomics' Scientists and Collaborators in Nature Biotechnology 4Accurate Identification of Tumor Origin Using MicroRNAs is Published by Rosetta Genomics' Scientists and Collaborators in Nature Biotechnology 5
... utilizies CTI Molecular Imaging's proprietary Focus™ ... sensitivty, and a large imaging volume ... to image multiple mice or large ... a dedicated small animal PET (Positron ...
...
These 18x18 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick....
...
Biology Products: