Navigation Links
System Drastically Cuts Down Botulism Detection Time

A new study reveals critical molecular events in the origin of fat cells. The findings are central to understanding chronic diseases, such as obesity and diabetes, as fat cells produce hormones critical for metabolic control, the researchers said.

The study finds that a hormonal cocktail routinely used in the lab induces a key genetic switch in the transition from fat-cell precursors to full-blown fat, researchers at University of Michigan Life Sciences Institute report in the September Cell Metabolism.

"The body needs fat cells, both as a storage depot for fuel and as cells that sense hormonal and energy status and in response, secrete hormones that maintain whole-body energy balance," said study author Alan Saltiel. "However, you don't want too many, big fat cells. It's a careful balance, and many diseases are associated with either extreme."

Lipodystrophies are disorders characterized by fat deficiency, Saltiel said. While obesity and lipodystrophy represent opposite ends of the spectrum, both are characterized by other metabolic disorders, such as insulin resistance, he added.

The generation of fat begins before birth and continues throughout life. The first step in fat production involves proliferation of mesenchymal stem cells, followed by differentiation into fat cell precursors called preadipocytes. Mesenchymal stem cells can differentiate into various cell types, including bone, cartilage, muscle, nerve, and fat.

Fat precursor cells then migrate and proliferate at the site of fat production, where they differentiate further to become spherical adipocytes.

"The multistep process is regulated by numerous hormones and is accompanied by dramatic changes in cell shape and gene expression," Saltiel said.

The team identified changes in the activity of hundreds of genes during the transition to fat cells, including a critical switch in gene activity--from integrin alpha 5 to integrin alpha 6. That switch allows
'"/>

Source:


Page: 1 2

Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. PANTHER Protein Classification System Database 5.0
5. Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
6. UCSD-Salk Team Show Protein’s Gene-Silencing Role In Development of Nervous System
7. White Blood Cell Waste Disposal System Plays Critical Regulatory Role
8. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
9. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
10. Breakthrough System for Understanding Ocean Plant Life Announced
11. Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: System Drastically Cuts Down Botulism Detection Time

(Date:5/19/2015)... 19, 2015 Research ... addition of the  "Genetic Testing Market Outlook ... http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, Genetic Testing ... of the current and future genetic testing ... their working principles and types are covered ...
(Date:5/14/2015)... 14, 2015 Research and Markets ( ... "Fingerprint Sensors Market in Smart Mobile Devices " ... that 2014 was a watershed year for fingerprint sensors ... ,Apple Pay,. Apple gave fingerprint sensors a raison d,etre ... Fingerprint sensors are a must-have feature in flagship smartphones. ...
(Date:5/11/2015)... 2015  Synaptics Incorporated (NASDAQ: SYNA ), ... announced the appointment of Wajid Ali ... reporting to Rick Bergman , President and ... Officer, Kathleen Bayless , who announced her ... Ali brings extensive financial management expertise to Synaptics, ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... than a decade to understand how tiny molecules called ... that microRNA actually moves between cells to help them ... of cells that grow and develop. This discovery ... including medical gene therapy and bioengineering of crop plants. ...
... simplify lab-on-a-chip devices that could offer quicker, cheaper ... researchers have created microfluidic integrated circuits. Just ... electricity on computer chips without external controls, these ... their devices without instructions from outside systems. ...
... is available in <A HREF=",http://chinese.eurekalert.org/zh/pub_releases/2010-04/sfeb-phr042210.php,">Chinese . ... with extraordinarily complex fluctuations across a wide range of ... both clinical and dynamical significance it may provide ... of the heart,s pacemaking system. In work published ...
Cached Biology News:Production of biofuels could benefit by controlling the types of cells that develop in plants 2Microfluidic integrated circuit could help enable home diagnostic tests 2Microfluidic integrated circuit could help enable home diagnostic tests 3Periodic heart rate decelerations in premature infants 2Periodic heart rate decelerations in premature infants 3
(Date:5/22/2015)... 22, 2015 According to a ... & 2D Gel Electrophoresis, Agarose & Polyacrylamide Gel, Capillary ... by Application & by End User - Global Forecast ... expected to reach around $1.98 Billion by 2020 with ... to 2020. Browse 226 ma ...
(Date:5/22/2015)... DALLAS , May 22, 2015 Baylor ... and the Translational Genomics Research Institute (TGen) in ... that will focus on accelerating early detection and treatments for ... science of both institutions will lead to new clinical trials ... therapies – bridging the gap from bench to bedside across ...
(Date:5/21/2015)... May 21, 2015 Specialty Pharmacy ... and been admitted to BPA Worldwide as a ... will track audience data for Specialty Pharmacy Times ... , “By becoming a member of BPA Worldwide, ... providing our clients with the most reliable, unequaled ...
(Date:5/21/2015)... CA (PRWEB) May 21, 2015 ... has announced a partnership with PicnicHealth, a healthcare ... patients. Participants diagnosed with Inflammatory Bowel Disease (IBD) ... as a complementary uBiome research kit. Both companies ... , For more information on ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4Specialty Pharmacy Times Joins BPA Worldwide 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3
... 2011 UCB, a leading biopharmaceutical company at the ... 2011 American College of Rheumatology (ACR) meeting by reinforcing ... and their healthcare providers. At this year,s ACR meeting, ... data with new findings on patient-reported quality of life ...
... SQNM ), a life sciences company providing innovative genetic ... third quarter of 2011, an increase of 16% compared to revenues ... for the third quarter of 2011 was $18.4 million or $0.19 ... $0.30 per share for the same period in 2010. ...
... NEW YORK, Nov. 3, 2011 Reportlinker.com announces ... in its catalogue: Global ... http://www.reportlinker.com/p0619270/Global-Biochip-Markets-Microarrays-and-Lab-on-a-Chip.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory INTRODUCTION  ... BCC,s goal for this study ...
Cached Biology Technology:UCB Reinforces Long-Standing Commitment to Rheumatology at American College of Rheumatology 2011 Annual Scientific Meeting 2UCB Reinforces Long-Standing Commitment to Rheumatology at American College of Rheumatology 2011 Annual Scientific Meeting 3UCB Reinforces Long-Standing Commitment to Rheumatology at American College of Rheumatology 2011 Annual Scientific Meeting 4Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 2Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 3Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 4Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 5Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 6Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 7Sequenom, Inc. Reports Financial Results for the Third Quarter of 2011 8Global Biochip Markets: Microarrays and Lab-on-a-Chip 2Global Biochip Markets: Microarrays and Lab-on-a-Chip 3Global Biochip Markets: Microarrays and Lab-on-a-Chip 4Global Biochip Markets: Microarrays and Lab-on-a-Chip 5
...
Troponin I Immunogen: Full length native protein (purified) (Human). Storage: -20 C, Avoid Freeze/Thaw Cycles...
Anti-SDF-1β/PBSF affinity isolated antibody lyophilized powder Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline recombinant human SDF-1β/PBSF expressed in E....
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake....
Biology Products: