Navigation Links
Sweetgum tree could help lessen shortage of bird flu drug

The sweetgum tree grows widely throughout the country and is known for its mace-like green fruit, which are sometimes called "gumballs." Now, this spiny fruit may become an important source of a chemical needed to make a lifesaving drug against bird flu ?a drug that is currently in short supply worldwide, researchers say.

Chemists have found that the seeds of the sweetgum fruit contain significant amounts of shikimic acid, the starting material used to produce the main antiviral agent in a much-heralded drug for fighting bird flu. Their findings, which could help increase the global supply of the drug, were described today at the 231st national meeting of the American Chemical Society, the world’s largest scientific society.

Shikimic acid is used to make a generic drug called oseltamivir ?best known commercially as Tamiflu® ?which is used to fight many types of flu viruses. Some health experts believe that this and similar antiviral drugs could help save lives by slowing the spread of the virus in the absence of a bird flu vaccine, which is still in development.

The drug, which blocks the replication of the flu virus, is being stockpiled worldwide to slow or stop a possible bird flu pandemic that some experts predict could kill millions ?if the virus mutates into a form that can spread from person to person. The virus, a strain known as H5N1, primarily afflicts birds at present but has been known to kill a small but growing number of humans who have had close contact with infected birds.

There is a skyrocketing demand for Tamiflu, but some experts fear there won’t be enough of the drug to treat everyone if a worldwide pandemic occurs. The supply problem resides in the drug’s source: The shikimic acid used to make it is obtained almost exclusively from the Chinese star anise, a fruit that is found mainly in China and whose supply has dwindled due to high demand for the flu drug. Although shikimic acid is found in many plants, star anise has been considered the most abundant plant source, until now.

"Our work gives the hearty sweetgum tree another purpose, one that may help to alleviate the worldwide shortage of shikimic acid," says study leader Thomas Poon, Ph.D., a professor of chemistry from the W.M. Keck Science Center at The Claremont Colleges in Claremont, Calif. "They have lots of potential for fighting bird flu."

The sweetgum tree grows widely throughout the United States and other parts of the world. In this country, it is particularly common in the South, including the Carolinas, Georgia and Alabama, but also can be found as far west as Missouri, Arkansas and Oklahoma and northward in parts of Illinois.

Although shikimic acid is found in the leaves and bark of the tree, it is most abundant in the fruit, Poon says. In the mature tree, the fruit emerges as a green seedpod that later dries into a brown, spiny husk, which releases an abundance of tiny, grain-like seeds. To optimize shikimic acid extraction, the gumballs need to be harvested when they are still green and before the seeds have been dispersed, Poon says. Each tree can hold hundreds, if not thousands, of seedpods.


'"/>

Source:American Chemical Society


Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Tiny particles could solve billion-dollar problem
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
5. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
6. How the environment could be damaging mens reproductive health
7. Dead zone area in Gulf could be increasing, researchers say
8. Growth in biomass could put US on road to energy independence
9. Nano-bumps could help repair clogged blood vessels
10. Researchers develop assay that could be applied to drug screening
11. Currents could disrupt ocean food chain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
(Date:5/9/2016)... UAE, May 9, 2016 Elevay ... comes to expanding freedom for high net worth professionals ... in today,s globally connected world, there is still no ... could ever duplicate sealing your deal with a firm ... passports by taking advantage of citizenship via investment programs ...
(Date:4/28/2016)... and BANGALORE, India , April 28, ... Systems, a product subsidiary of Infosys (NYSE: INFY ... announced a global partnership that will provide end ... use mobile banking and payment services.      (Logo: ... key innovation area for financial services, but it also plays ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... San Diego, CA (PRWEB) , ... June 27, 2016 , ... ... mClinical solutions for clinical trials, announced today the Clinical Reach Virtual Patient ... and their care circle with the physician and clinical trial team. , Using the ...
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
Breaking Biology Technology: