Navigation Links
Sweet 'water taste' paradoxically predicts sweet taste inhibitors

A scientific paradox linking artificial sweeteners such as saccharin with a sensory experience in which plain water takes on a sweet taste has guided researchers to an increased understanding of how humans detect sweet taste.

Reporting in an advance online publication in Nature, scientists from the Monell Chemical Senses Center describe how certain artificial sweeteners, including sodium saccharin and acesulfame-K, paradoxically inhibit sweet taste at high concentrations. The researchers further report that taste perception switches back to sweetness when these high concentrations are rinsed from the mouth with water, resulting in the aftertaste experience known as sweet 'water taste.'

The Nature article describes the phenomenon of sweet 'water taste' and then goes on to explain it at the level of the sweet taste receptor.

"These findings will open doors for tweaking the sweet taste receptor and finding new sweeteners and inhibitors that can be used both by food industry and in medicine," states senior author Paul A.S. Breslin, PhD, a Monell geneticist.

Lead author Veronica Galindo-Cuspinera, PhD, noted while working on a separate study that saccharin ?commonly used at low concentrations as an artificial sweetener ?loses its initially sweet taste when tasted at high concentrations. Galindo-Cuspinera subsequently observed that strong sweetness returned when the high concentrations of saccharin were rinsed from the mouth with water.

Working with Breslin, she next discovered that high concentrations of saccharin inhibit the sweetness of any other sweetener tasted at the same time.

Testing a variety of compounds, the researchers found that any sweetener that elicits sweet 'water taste' also acts as a sweet taste inhibitor.

To understand how sweet 'water taste' compounds could act both as a sweetener and as a sweet inhibitor, collaborators Marcel Winnig, Bernd Bufe, and Wolfgang Meyerhof of the German Insti
'"/>

Source:Monell Chemical Senses Center


Page: 1 2

Related biology news :

1. Sweetgum tree could help lessen shortage of bird flu drug
2. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
3. Ocean climate predicts elk population in Canadian Rockies
4. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
5. Rensselaer researchers develop approach that predicts protein separation behavior
6. Eleven gene signature reliably predicts cancer prognosis
7. Signature of chromosome instability predicts cancer outcomes
8. Blood test predicts success of quitting smoking using the nicotine patch
9. First-ever genomic test predicts which lung cancer patients need chemotherapy to live
10. Ocean temperature predicts spread of marine species
11. Math model predicts cancer behavior
Post Your Comments:
(Date:12/19/2014)... 2014 Research and Markets ( ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... in July 2012, Apple introduced the fingerprint reading ... the only device of Apple incorporating such a ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile ... Internet of Things era, today announced the close of ... was led by Metamorphic Ventures with participation from ENIAC ... and others.  LaunchKey has raised $4 million to date, ... team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... the first time, demonstrated that mercury concentrations in fish respond ... The international teams research began in 2001 at the ... weeks Proceedings of the National Academy of Sciences. Up ... because of all the other factors that affect mercury levels ...
... have determined the three-dimensional structure of an unusual viral ... viruses. The Paramecium bursaria chlorella virus infects a ... cells. Once inside the chlorella, the virus DNA makes ... structural proteins that are assembled to create the outer ...
... smoking-cessation drug will enable you to quit smoking may ... from the Centre for Addiction and Mental Health (CAMH). ... journal Biological Psychiatry, found that the enzyme known to ... is highly genetically variable in all ethnicities and influences ...
Cached Biology News:International team shows mercury concentrations in fish respond quickly to increased deposition 2Scientists learn structure of enzyme in unusual virus 2New genetic research into nicotine addiction shows promise for personalized treatment 2
(Date:12/24/2014)... , December 23, 2014 ... Algeria , out today and available for free download ... actors driving change and growth in the sector today. ... scored notable successes has been in developing a homegrown pharmaceutical ... percent local production still remains some way off. A cursory ...
(Date:12/22/2014)... & Brussels (PRWEB) December 22, 2014 ... (CfPIE), the global leader of technical training across the ... for Clinical Data Management (SCDM) to provide the ... certification programs —providing access to the more than ... extends SCDM members with 10% off when registering for ...
(Date:12/22/2014)... -- GenomeDx Biosciences today announced that a new study ... test for prostate cancer, was able to predict rapid ... prostatectomy without adjuvant therapy. Although rapid metastasis in men ... genomics to identify these men who have a highly ... The study has been published online by the ...
(Date:12/22/2014)... TENN (PRWEB) December 22, 2014 Fertility ... Donor Egg Bank USA , a network of ... country. Through this partnership, patients have fast access to ... in vitro fertilization, IVF . Fertility Associates of Memphis ... offer this fertility treatment option. , Dr. William ...
Breaking Biology Technology:PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3
... Viragen, Inc. (OTC,Bulletin Board: VRAI) and its ... VRGE), today jointly announced,that Viragen International,s wholly-owned ... an application seeking protection under the,bankruptcy laws ... alpha interferon. The bankruptcy application was ...
... at 10:30 ET, 7:30 PT, EMERYVILLE, Calif., Sept. ... today announced its financial,results for its fiscal fourth quarter ... 1-for-7 reverse split of its common stock. For ... million, a,44% increase over last year,s revenue of $12.3 ...
... Germany, Sept. 14 Indivumed announces today,that a ... Within,this agreement Indivumed will apply its automated immunohistochemistry,service ... in the,area of oncology. Indivumed will provide for ... its tumor biobank as well as specifically,collected clinical ...
Cached Biology Technology:Viragen International's Subsidiary, ViraNative AB, Files to Seek Bankruptcy Protection in Sweden 2Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 2Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 3Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 4Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 5Neurobiological Technologies, Inc. Reports Fourth Quarter and Fiscal Year-End Financial Results for 2007 Announces 1-for-7 Reverse Stock Split 6