Navigation Links
Susceptibility to Crohn's disease -- an important new clue

Crohn’s disease is a chronic relapsing inflammatory disorder of the intestinal tract that affects an estimated 0.15% of people in the developed world. Common symptoms include abdominal pain and diarrhea, but the disorder is often associated with debilitating clinical complications. Researchers from the University of Liège, Belgium, have now uncovered an important clue to the susceptibility of individuals to this disease.

In a genome-wide association study with more than 300,000 single nucleotide polymorphisms (SNPs) ?DNA sequence variations occurring when a single nucleotide in the genome differs between members of a species ?Cécile Libioulle et al. identified a new susceptibility locus for Crohn’s disease. Their results are published online in the open-access journal PLoS Genetics.

Recent advances in SNP genotyping technology have allowed systematic association scanning of the entire genome for the detection of novel susceptibility loci ?fixed positions on a chromosome, such as the position of a gene. Libioulle and colleagues applied this approach to Crohn’s disease and identified the key locus on chromosome 5.

Individual susceptibility to many common diseases, including Crohn’s disease, is determined by a combination of environmental and genetic factors and identifying these genetic risk factors is one of the most important objectives of modern medical genetics, potentially paving the way towards personalized medicine and drug target identification.


'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation
2. Crohns disease gene identified
3. Scientists find new genes for Crohns disease
4. Neuronal traffic jam marks early Alzheimers disease
5. Scientists detect probable genetic cause of some Parkinsons disease cases
6. Ecological destruction fuels emerging diseases
7. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
8. U of M researcher examines newly emerging deadly disease
9. Marburg virus disease in Angola - update
10. Molecular machine may lead to new drugs to combat human diseases
11. Female sex hormones play a vital role in defense against sexually transmitted diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... , June 9, 2016 ... Police deploy Teleste,s video security solution to ensure the safety ... France during the major tournament Teleste, ... communications systems and services, announced today that its video security ... to back up public safety across the country. ...
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: ... been advised by its major shareholders, Clean Technology Fund ... United States based venture capital funds ... of Biorem (on a fully diluted, as converted basis), ... disposition of their entire equity holdings in Biorem to ...
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... just published their findings on what they believe could be a new and ... of the new research. Click here to read it now. , ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... and solutions to the healthcare market. The company's primary focus is on new ... and marketing strategies that are necessary to help companies efficiently bring their products ...
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... the funding of a Sponsored Research Agreement with ... tumor cells (CTCs) from cancer patients.  The funding ... CTC levels correlate with clinical outcomes in cancer ... data will then be employed to support the ...
Breaking Biology Technology: