Navigation Links
Survival of heart patients on beta-blockers varies greatly with genetic variation

to relieve stress on the heart. They also block impulses that can cause rhythm disturbances.

"Long-term therapy with beta-blockers is standard care for heart patients," Lanfear says. "Data from patients with acute myocardial infarction have shown that beta-blockers are generally effective. They are known to decrease the size of the infarct and seem to prolong survival, on average."

Recent research, however, reveals that variations in the beta-adrenergic receptor genes affect the benefit of beta-blockers in heart patients. Data indicate that variations of the genes influence such parameters as blood pressure response in hypertensive patients and heart function in heart failure patients.

"But this is the first time that anyone has shown that these genetic variations affect survival," McLeod says.

Humans have two types of beta-adrenergic receptors, beta-1 and beta-2. In this study, the researchers found no difference in survival associated with variations of the beta-1 gene. But variations in the beta-2 gene significantly determined length of survival for ACS patients who were taking beta-blockers. For those patients not taking beta-blockers, variations in the beta-adrenergic receptor genes showed no evidence of effect on survival, although small sample size makes this result uncertain.

The beta-2 gene commonly has two points of sequence variation within the human population--for most of the population, the gene's coding sequence will be identical from person to person at all other points. Thirty-nine percent of the population possess a set of beta-2 genes with a C base at position 79, and 16 percent possess at set of beta-2 genes with an A base at position 46.

In this study, ACS patients on beta-blockers with either of these two specific genetic variations constituted the high-risk group--by the end of three years, 20 percent of this group had died. By comparison, patients who had G bases at position 79 or 46 on both
'"/>

Source:Washington University School of Medicine


Page: 1 2 3 4

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
3. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
4. Survival of the selfless - scientists find cheats dont always prosper
5. Survival of the rarest: Fruit flies shed light on the evolution of behavior
6. UCSD team discovers specialized, rare heart stem cells in newborns
7. Single stem cells from bone heal a broken heart
8. Python a hearty eater
9. Columbia study shows widely used artery clearing device does not help patients during heart attack
10. Researchers reveal secret of key protein in brain and heart function
11. Stem cell therapy successfully treats heart attack in animals
Post Your Comments:
(Date:7/24/2014)... planet,s current biodiversity, the product of 3.5 billion years ... the history of life. But it may be reaching ... scientific literature and analysis of data published in ... the loss and decline of animals is contributing to ... planet,s sixth mass biological extinction event. , Since 1500, ...
(Date:7/24/2014)... MADISON A multi-institutional team of researchers has developed ... tract. This safe, noninvasive method for assessing the function ... could lead to better diagnosis and treatment of gut ... bacterial overgrowth, irritable bowel syndrome and inflammatory bowel disease ... serious side effects in patients with diseases such as ...
(Date:7/24/2014)... counterparts in humans, affect the connections between nerve cells ... hippocampus, an area of the brain that plays a ... memories. The results of the study have been published ... depends on the active communication between nerve cells, known ... into a dense network where they constantly relay signals ...
Breaking Biology News(10 mins):Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3New imaging agent provides better picture of the gut 2A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4
... passed on from mother to child is decided very early ... ovary. In a cell division process that is unique to ... egg before it is fertilised. Using a powerful microscope, researchers ... how the molecular machinery functions that is responsible for chromosome ...
... long-held belief that plant-eating insects in tropical forests are ... dining only on locale-specific vegetation is being challenged ... on a broader menu of foliage and can be ... These findings have significant implications related to ...
... just whats in your genes, its how you turn them on ... yeast according to a report by Yale researchers in this ... the protein coding genes of humans and chimpanzees are about 99 ... Cullman Professor of Molecular Cellular and Developmental Biology at ...
Cached Biology News:A unique arrangement for egg cell division 2Tropical insects 'go the distance' to inform rainforest conservation 2Evolution is driven by gene regulation 2
(Date:7/25/2014)... 25, 2014 At the request of ... a 60-day extension for the public comment period (Docket ... for Model Aircraft established by Congress as part of ... 60-day extension establishes the new deadline for comments as ... of Transportation/FAA notice published in the Federal Register on ...
(Date:7/24/2014)... Calif. , July 24, 2014  Now available ... to home. Rehealth Regenerative Therapies , located in ... and other physically active people a new health option: ... Regardless of age, countless patients suffer from joint ... activities, such as muscle tears, torn rotator cuff, tennis ...
(Date:7/24/2014)... to materialise. Yet, scientists are making progress in ... One such approach relies on quantum dotsa kind ... electric field. A new study demonstrates that changing ... (TQDs) with electrical impulses can help better control ... be used as quantum information units, which would ...
(Date:7/24/2014)... Your cell phone may stay charged ... storage capacity. , New research indicates that lithium-ion ... at Lawrence Livermore National Laboratory and ... components will perform as electrodes. , The growing ... for higher-performance batteries. Several key characteristics of lithium-ion ...
Breaking Biology Technology:FAA Grants Comment Extension at the Request of AMA 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Getting More Life out of Lithium-ion Batteries 2
... GenVault,s energy and space efficient technologies ideally suit ... create a new paradigm for eco-friendly, sustainable Biobanking ... announces the opening of its newly-formed Japanese subsidiary ... the expanding Biobanking market and its growing customer ...
... Therapeutics, Inc., a privately held ophthalmic-focused biopharmaceutical company, today ... ophthalmic gel, 0.15%, has been accepted for review by ... is seeking approval for ganciclovir as a treatment for ... simplex virus. The FDA has issued an action date ...
... 26 Fifty percent of clinical trial management ... share high-value, proprietary company information via e-mail, while ... overnight courier (14 percent), according to a recent ... for exchanging clinical trial information with outside parties ...
Cached Biology Technology:GenVault Opens Japanese Subsidiary to Better Address Global Biobanking Market Growth 2Sirion Therapeutics New Drug Application for Ganciclovir is Accepted for Review by the FDA for the Treatment of Ocular Herpes 2Sirion Therapeutics New Drug Application for Ganciclovir is Accepted for Review by the FDA for the Treatment of Ocular Herpes 3IntraLinks Poll: Half of Clinical Trial Management Professionals Share Critical Information Via E-Mail 2
... General description: Humidity wells in the base ... chamber humidity and probe hydration around the ... eliminates the risk of waterbath contamination. This ... temperature waterbaths or hybridisation ovens. Linkage: This ...
... Protein DetectorTM Microarray Dot Blot Kits ... accuracy and quantitation over a wide range ... formats ) detection. They are ideal ... profiling hundreds of samples for the presence ...
... Slide features an ultra-thin nitrocellulose coating ... the first protein microarray slide to ... in a thin film with low,background ... ,The PATH™ Slide can be used ...
... Stabilizer is an aqueous solution that ... other non-toxic stabilizing chemicals in a ... 6.5. This product contains ... 0.02% bromonitrodioxane as a preservative. ...
Biology Products: