Navigation Links
Surprise finding for stretched DNA

lue. This observation also implies that if we overwind the DNA, the molecule should get longer. Indeed, we found that Overwinding caused the DNA molecule to extend by about 0.5 nanometers per turn."

To explain the overwinding, Bustamante and his coauthors have proposed a simple "toy" model in which the radius of the DNA double-helix is allowed to shrink as the molecule is stretched. The model consists of an elastic rod that is wrapped around its outer surface by a stiff wire, analogous to DNA's sugar-phosphate backbone. The elastic rod is constructed from a material that conserves volume under stress.

"As this system is stretched, the elastic rod decreases in diameter," said Bustamante. "This enables the outer wire to wrap a larger number of times over the length of the rod."

The twist-stretch coupling results demonstrated by Bustamante and his collaborators holds important implications for how DNA-binding proteins are able to recognize their target sites along the helix. These proteins are known to bend, wrap, loop and twist DNA. Now it has been shown that they can achieve their goals by simultaneously stretching and overwinding a DNA molecule, or by compressing and underwinding it.

"We believe that our work sheds new light on an old and important problem," said Bustamante, "and that, in addition to improving our understanding of DNA/protein interactions, it will also have implications in nanotechnology. For example, the DNA molecule might provide the energy to power future nanomotors."


'"/>

Source:DOE/Lawrence Berkeley National Laboratory


Page: 1 2 3

Related biology news :

1. Surprising findings reported about iron overload
2. Liposome finding implies electrical effect on cell development
3. Evolution of life on Earth may hold key to finding life in outer space
4. LIAI scientists make major finding on potential smallpox treatment
5. Study findings offer potential new targets for antibiotics
6. The worlds deepest dinosaur finding - 2256 metres below the seabed
7. Protein finding could lead to treatment for inflammatory diseases
8. Oops! Researchers publish new findings on the brains response to costly mistakes
9. Inside rocks, implications for finding life on Mars
10. Biodiversity key to sustainable biofuel according to University of Minn. researchers findings
11. New findings offer more complete view of breast cancer gene mutations in US population
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Surprise finding for stretched DNA

(Date:4/18/2014)... Ill. For the past 20 years, researchers have ... the research findings have suggested that soil organic carbon ... conventional tillage systems to no-till systems. However, there is ... systems in corn and soybean rotations without cover crops, ... organic carbon stocks at the published rates. , "Some ...
(Date:4/18/2014)... Calif. A team of researchers led by ... been selected to receive a $7.5 million Department of ... simple and basic scientific foundations for the predictable design ... a wide diversity of structures from plants and animals, ... are taking what biological systems have constructed over millions ...
(Date:4/17/2014)... there was a word for chili peppers. Information about ... with a study of the appearance of words for ... where jalapeos were domesticated and highlight the value of ... Kraft et al.) of nine papers presented in a ... National Academy of Sciences on plant and animal ...
Breaking Biology News(10 mins):Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Mantis shrimp, toucan and trilobite, oh my 2Mantis shrimp, toucan and trilobite, oh my 3Chickens to chili peppers 2Chickens to chili peppers 3
... on biodiversity pose a serious conservation challenge for marine life, ... may need to relocate faster than land species as well ... cycle events. This challenges previous thinking that marine life in ... because of slower warming in the oceans. "Analyses of ...
... University of Cambridge study, which set out to investigate DNA ... our lifestyle and our health, has now mapped the link ... data collected greatly benefits a field that is still in ... where the researchers were, even 18 months ago. ...
... from UCLA,s cancer and stem cell centers have demonstrated for ... to create cancer-killing T-cells that seek out and attack a ... in 40 percent of Caucasians with this malignancy. Done ... blood stem cells, which make every cell type found in ...
Cached Biology News:No plain sailing for marine life as climate warms 2No plain sailing for marine life as climate warms 3Environment and diet leave their prints on the heart 2UCLA researchers engineer blood stem cells to fight melanoma 2UCLA researchers engineer blood stem cells to fight melanoma 3
(Date:1/14/2014)... UK (PRWEB) January 13, 2014 Bob ... with more than 20 years in the industry, has ... photonics . Hainsey will serve as the society’s Science ... Dr. Hainsey join SPIE as our Technology Strategist, further ...
(Date:1/14/2014)... 2014 During the 1600’s through the 1800’s ... Doctor’s Plague.” In this time period, doctors did not know ... times, to the death of vulnerable patients. In the same ... they may be unwittingly transmitting herpes viruses to their patients. ...
(Date:1/14/2014)... BioMedomics, Inc. , a Point of Care ... novel disease specific POC tests, announced today that it has ... of $690,000. The investment is from private investors and is ... of private investors has significant successful experience in early investments ...
(Date:1/14/2014)... Translational Biosciences, a subsidiary of ... trial approval for the treatment of rheumatoid arthritis ... from the Comité Nacional de Bioética de la ... (RA) is an autoimmune disease in which the ...
Breaking Biology Technology:Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3BioMedomics, Inc. Closes $690K Round of Financing 2Panama’s First Umbilical Cord Stem Cell Clinical Trial for Rheumatoid Arthritis Approved by Comité Nacional de Bioética de la Investigación Institutional Review Board 2Panama’s First Umbilical Cord Stem Cell Clinical Trial for Rheumatoid Arthritis Approved by Comité Nacional de Bioética de la Investigación Institutional Review Board 3
... ... Screening Capabilities Yield High-quality Data for the Broad Institute,s NIH-funded Molecular Libraries and Imaging ... Lexington, ... leading provider of in silico solutions for pharmaceutical R&D and related life sciences, today ...
... Oct. 5 Verenium Corporation (Nasdaq: VRNMD ), ... and high-performance specialty enzymes, today announced that it intends ... shares of its common stock, and potentially warrants, in ... to price before 9:30 am EDT on Tuesday, October ...
... UPPSALA, Sweden, October 5 , ... - At One Sixth the Price of QuanTyper(TM) Without Loss ... to Rapidly Penetrate the Market , AlphaHelix ... - AmpXpress(TM) - to meet demands for lower,instrument prices. This was ...
Cached Biology Technology:Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 2Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 3Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 4Verenium Announces Proposed Public Offering of Common Stock 2Verenium Announces Proposed Public Offering of Common Stock 3AlphaHelix Presents AmpXpress(TM) at the BIOTECHNICA Show 2
...
... supplies, for 10 chips, provides the ... standard-sensitivity RNA analysis (nanogram levels) with ... electrophoresis system. Supplied are 1,250 microliters ... stain, 20 microliters RNA ladder, 900 ...
MAb to Verotoxin II (SLT-2a) Verotoxin II (Shiga-like) A subunit (SLT-2a)...
...
Biology Products: