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Suppressing growth hormone in early adulthood may prevent cancer

numerous cell types and cancers. "IGF-1 levels in the blood can be reduced by low-calorie diets, which could be a mechanism for the diet-cancer relationship," said Sonntag, whose work explores the neurobiology of aging.

Previous studies in some animals indicate that a reduction in IGF-1 activity increases lifespan. To date, there are no studies of a specific suppression of IGF-1 on aging or age-related diseases.

In the current study, Sonntag found that a life-long deficiency of IGF-1 decreased cancer risk by approximately 45 percent and decreased cancer deaths by 12-15 percent.

"Besides reducing the incidence of cancer in these rats, we found that a modest suppression of plasma IGF-1 beginning shortly after puberty and continued throughout life reduces the incidence of kidney disease and increases lifespan," Sonntag said.


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Source:Wake Forest University Baptist Medical Center


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