Navigation Links
Suppressing growth hormone in early adulthood may prevent cancer

A modest suppression of growth hormone and related compounds beginning in early adulthood may delay the onset or progression of several types of cancer, researchers from Wake Forest University School of Medicine and other centers reported today at ENDO 2005, the annual meeting of the Endocrine Society, in San Diego.

Suppression of growth hormone and insulin-like growth factor (IGF-1) also may decrease cancer risk in those individuals at high risk for disease, and perhaps could be a preventive measure, said William E. Sonntag. Ph.D., the lead investigator, who based his findings on research in rats.

He said IGF-1 is an important blood-borne factor that increases cell growth and prevents cell death and has been proposed to be a factor in the initiation of cancer.

"Elevated IGF-1 levels in pre-menopausal women have been demonstrated to be a risk factor for breast cancer as well as numerous other cancers," said Sonntag, professor of physiology and pharmacology at the School of Medicine, a part of Wake Forest University Baptist Medical Center.

IGF-1 in the blood also may act as a tumor promoter during the early development of cancer, he said.

Although additional research is needed, he said, drugs in the somatostatin class are currently available to suppress growth hormone and IGF-1 in people, so somatostatin analogs could be given as preventative measures to lower plasma IGF-1 before the onset of disease, especially in high-risk people.

In a previous study, rats with high levels of growth hormone (a circulating factor that increases IGF-1 levels) exhibit an increase in spontaneous mammary tumors. Dwarf animals with 50 percent lower IGF-1 levels do not develop tumors in response to a chemical carcinogen. But Sonntag said that if these dwarf rats are given growth hormone to increase IGF-1 in the blood, tumors develop at the same rate as in the normal animals.

Suppression of IGF-1 activity inhibits the proliferation of numerous cell types and cancers. "IGF-1 levels in the blood can be reduced by low-calorie diets, which could be a mechanism for the diet-cancer relationship," said Sonntag, whose work explores the neurobiology of aging.

Previous studies in some animals indicate that a reduction in IGF-1 activity increases lifespan. To date, there are no studies of a specific suppression of IGF-1 on aging or age-related diseases.

In the current study, Sonntag found that a life-long deficiency of IGF-1 decreased cancer risk by approximately 45 percent and decreased cancer deaths by 12-15 percent.

"Besides reducing the incidence of cancer in these rats, we found that a modest suppression of plasma IGF-1 beginning shortly after puberty and continued throughout life reduces the incidence of kidney disease and increases lifespan," Sonntag said.


'"/>

Source:Wake Forest University Baptist Medical Center


Related biology news :

1. Plants, animals share molecular growth mechanisms
2. U-M scientists find genes that control growth of common skin cancer
3. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
4. Researchers discover chemical compounds that affect plant growth
5. Physical and functional interaction of key cell growth molecules linked to cancer
6. Hormones and growth: The control of body size and developmental growth rate in fruit flies
7. Researchers find molecule that inhibits regrowth of spinal nerve cells
8. Gradient guides nerve growth down spinal cord
9. Scientists discover genetic pathway responsible for breast cancer cell growth
10. Breath of the dragon: ERS-2 and Envisat reveal impact of economic growth on Chinas air quality
11. Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... July 20, 2017 Delta (NYSE: DAL ) customers ... Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft ... Delta,s biometric boarding pass ... is now integrated into the boarding process to allow eligible Delta ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for ... has been officially launched in Genoa, Italy . The ... and the USA . The technology was ... the market by the IIT spin-off Movendo Technology thanks to a 10 ... Multimedia News Release, please click: ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... ... pharmaceutical and biotherapeutics development, announces the launch of the new NHS Agile ... gain kinetic binding data for a wide range of molecules, including small and ...
(Date:8/15/2017)... ... August 15, 2017 , ... The Conference Forum and ... programming through a series of upcoming panels and events. The partnership culminates with the ... Roosevelt Hotel in New York City. , “With our experience in producing the Immuno-Oncology ...
(Date:8/14/2017)... ... 2017 , ... Opal Kelly, a leading producer of powerful ... the release of SYZYGY™, a new open standard for connecting high-performance peripherals to ... low cost, low pin-count, high-performance connectivity solution between FPGAs and single-purpose hardware peripherals. ...
(Date:8/11/2017)... ... August 11, 2017 , ... Algenist continues to disrupt the ... collagen like never before. , Collagen is the key structural element skin needs ... Liquid Collagen™, which include: , First to market with ...
Breaking Biology Technology: