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Supersized 'island' of resistance genes discovered in an infectious bacterium

up some kind of easily accessible 'shelves' to store the antibacterial resistances genes as they become needed and are available in the environment," Claverie said.

The research team compared the entire genomes of two A. baumannii strains, one completely susceptible to antibiotics and one highly resistant.

"This is the first study of its kind to study the resistance mechanisms of a bacterial strain by whole genome sequencing," said Fournier. "Our strategy of sequencing the whole genome of a bacterial strain with specific features is valuable and fast."

Resistant A. baumannii has become a major public health concern worldwide. Recently, a high incidence of resistant A. baumannii was reported in US Army service members injured in Afghanistan and Iraq. In France, the resistant strain is widespread in 54 healthcare facilities, where 26% of infected patients die.

"Less than 2 years after the start of the French epidemic episode, we found the complete genome ID of the microbe involved and developed a better understanding of what to expect for the future, in terms of new antibiotic resistance," Claverie said. "This work will guide a future international effort on identifying all major A. baumannii resistant strains throughout the world, and help follow the emergence of new strains and understand their mode of evolution."


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Source:Public Library of Science


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