Navigation Links
Supercomputers to focus brains on AIDS dilemma

erck's drug discovery group, and her colleagues at Merck and the Instituto Ricerche di Biologia Moleculaire in Rome published in the August 3, 2004 Proceedings of the National Academy of Sciences reports on how the molecular dynamics simulations of the McCammon group dovetailed with Merck research, helping the company's scientists make sense of puzzling data of their own: seemingly similar inhibitors were binding to different parts of the enzyme's active site region. "With the help of our simulations, the Merck scientists were able to understand this and then go on to prove experimentally the effectiveness of compounds in binding to different parts of the HIV integrase enzyme," said McCammon.

Because of the great promise these compounds are showing for treating HIV/AIDS, the Merck scientists are proceeding with development of a series of drug candidates that rely on the remarkable flexibility revealed by the McCammon group's simulations in the integrase binding site. The first of these compounds is expected to go into clinical trials this year, with UCSD as one of the trial sites.

The Merck scientists have chosen a drug development strategy in which they are developing "single wing" compounds, whose wings, or cyclic moieties, can bind to either the west or the east in the integrase enzyme. "These compounds are especially interesting because they'll be less likely to lead to drug-resistant strains of HIV-1," said McCammon. This is because the inhibitor can flip to the east if an integrase mutation arises in the west, or to the west if a mutation arises in the east. And because emerging HIV-1 mutations have significantly reduced the usefulness of many previously effective drugs, maintaining the ability to bind even when mutations occur is an important advantage.

"These results, combining our computer simulations at SDSC and Merck experimental research, are giving real hope that the remarkable story of molecular dynamics simulations in helping d
'"/>

Source:SDSC


Page: 1 2 3 4

Related biology news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Scientists focus on dwarf eye
3. NIH renews network focused on how genes influence drug responses
4. WCS says avian flu prevention should focus on farms, markets
5. Brains response to visual stimuli helps us to focus on what we should see, rather than all there is to see
6. Report focuses on challenges to unlocking future promise of vaccines
7. A new focus for the mechanism of nerve growth
8. First encyclopedia of nuclear receptors reveals organisms focus on sex, food
9. New light microscope sharpens scientists focus
10. Reversing hibernating heart muscle focus of UB researchers
11. Report focuses on the role good microbes play in future medicine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Supercomputers focus brains AIDS dilemma

(Date:7/8/2015)... , N.J. and NEW YORK , July ... Guidepoint today announced BD & Guidepoint ... companies with free access to Guidepoint,s expert network services. ... that are developing cutting-edge technologies to improve healthcare delivery ... Guidepoint research manager, each start-up entrepreneur will be able ...
(Date:7/7/2015)... DUBLIN , June 30, 2015 ... ) has announced the addition of the ... their offering. To this date, fingerprint ... biometric technology and fingerprint sensors are well developed. ... capacitive sensing technology. The domain of ...
(Date:7/2/2015)... 25, 2015 Research ... of the "Natural Language Processing Market by ... OCR, Pattern & Image Recognition) - Worldwide Forecast ... The key vendors occupying the market are ... Microsoft Corporation, NetBase Solutions, SAS Institute Inc., Verint ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2
... people take the anticoagulant drug warfarin to prevent harmful clotting ... proper dose of warfarin can vary greatly and can be ... to a recently identified gene involved in blood clotting, according ... of The New England Journal of Medicine. , By looking ...
... researchers showed that a fruit fly gene is crucial ... and how the transformation initially proceeds. Understanding this process ... surly teenagers. , When the DHR4 gene is disabled, ... larva to a sexually active adult. It is the ...
... biochemical pathways that plants use to defend themselves against ... of each other. , Knowing how these pathways of ... that can better resist a variety of pathogens, said ... professor of horticulture and crop science at Ohio State ...
Cached Biology News:Genetic variation alters response to common anti-clotting drug 2Genetic variation alters response to common anti-clotting drug 3MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools 2MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools 3MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools 4Study: Plants use dual defense system to fight pathogens 2
(Date:7/30/2015)... 30, 2015 AACC welcomed thousands of ... AACC Annual Meeting & Clinical Lab Expo in ... The meeting showcased revolutionary advancements in clinical testing ... healthcare providers to diagnose patients quickly and accurately ... As of Wednesday, July 29, ...
(Date:7/30/2015)... CAMBRIDGE, Mass. , July 30, 2015 /PRNewswire/ ... software solutions for the interpretation and analysis of ... Matthew Fischer has joined the company ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... astounding capabilities to integrate, interpret, analyze and explore ...
(Date:7/30/2015)... Dallas, TX, USA (PRWEB) , ... July 30, ... ... nano and microsystems, has appointed Francois Vieillard as Sales & Marketing Director. ... executive positions, Francois Vieillard will be responsible for reinforcing Tronics’ business development activities ...
(Date:7/30/2015)... ... 2015 , ... The 2015 Market Research Report on the Global Propanol ... global Propanol market with a focus on the Chinese situation. Major companies included in ... ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , The ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Tronics appoints Francois Vieillard as Sales and Marketing Director 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3
... CryoLife, Inc. (NYSE: CRY ),a biomaterials, medical ... A. Theodore has been named vice president, general,counsel, ... directly to,Steven G. Anderson, chairman, president and chief ... Mr. Theodore will be responsible for all corporate,legal ...
... Dr. Andreas Krause to Present on Statistical Considerations for Model, ... and Simulation ... ... (OTC Bulletin Board: PHST), a leading provider of software and,strategic ...
... The 100 Most-Promising Private Technology Ventures Celebrated at Event in ... ... Sept. 3 /Xinhua-PRNewswire/ -- Red Herring,Magazine announced that the leading China ... winner of the,prestigious ,Red Herring 100 Asia, 2007 awards. The news ...
Cached Biology Technology:CryoLife Names Philip Theodore as Vice President, General Counsel 2Pharsight to Present at ROeS Seminar in Bern, Switzerland on September 10 & 11, 2007 2Pharsight to Present at ROeS Seminar in Bern, Switzerland on September 10 & 11, 2007 3Miaxis Biometrics Named as 'Red Herring 100 Asia' Award Winner for 2007 2Miaxis Biometrics Named as 'Red Herring 100 Asia' Award Winner for 2007 3
Polaroid black & white positive, 3 x 4 inch pack film, ISO 3000/ 36 ASA DIN (20 expsures). For use in the Polaroid Direct Copy Camera (PHC34)....
Request Info...
SHEEP ANTI ECHIS OCCELATUS (VENOM)...
... ExcelGel DNA Analysis Kit, 1. ... and high resolution DNA typing. *Semi-dry ... and clean-up. *Precast, plastic-backed gels and ... convenience and detection sensitivity. Category: ...
Biology Products: