Navigation Links
Supercomputers to focus brains on AIDS dilemma

More than two decades after it burst onto the scene, HIV/AIDS has claimed more than twenty million lives and continues to devastate societies around the world, particularly in Africa and other developing countries. In the late 1980s and early 1990s, after years of effort AIDS researchers succeeded in developing a class of drugs that proved to be highly effective against AIDS. By blocking the activity of the viral enzyme HIV protease, these protease inhibitors brought greatly extended life-spans to patients who previously faced early deaths. Structural biology and molecular dynamics computer simulations played an important role in these discoveries.

However, in recent years, mutant strains of HIV have shown increasing resistance to many of these formerly effective drugs, raising the specter of reduced life-spans and wider spread of HIV.

"Fortunately, in this ongoing battle, computational and structural biology may once again be on the verge of contributing a new class of drugs for the treatment of HIV/AIDS," said J. Andrew McCammon, a Howard Hughes Medical Institute investigator and UCSD professor of Pharmacology who holds the Joseph Mayer Chair of Theoretical Chemistry at UCSD. "This time, we're targeting HIV integrase, the only HIV enzyme for which no effective drugs have previously been discovered." The other two HIV enzymes are reverse transcriptase, the target for AZT and other drugs, and protease, the target for the protease inhibitors that had proven so effective until the recent emergence of drug-resistant mutants.

The new drug possibilities flow out of a long series of molecular dynamics simulations by McCammon's group. These simulations have focused on the catalytic domain of HIV-1 integrase, and relied on the large-scale computational resources of the San Diego Supercomputer Center (SDSC) at UC San Diego. In 1999, related results from traditional x-ray crystallography studies of the structure of a complex between the HIV-1 integrase
'"/>

Source:SDSC


Page: 1 2 3 4

Related biology news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Scientists focus on dwarf eye
3. NIH renews network focused on how genes influence drug responses
4. WCS says avian flu prevention should focus on farms, markets
5. Brains response to visual stimuli helps us to focus on what we should see, rather than all there is to see
6. Report focuses on challenges to unlocking future promise of vaccines
7. A new focus for the mechanism of nerve growth
8. First encyclopedia of nuclear receptors reveals organisms focus on sex, food
9. New light microscope sharpens scientists focus
10. Reversing hibernating heart muscle focus of UB researchers
11. Report focuses on the role good microbes play in future medicine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Supercomputers focus brains AIDS dilemma

(Date:7/10/2014)... , June 27, 2014  The American Academy ... Institute of Standards and Technology (NIST) and the ... academic research and forensic science expert members to ... is an element of the NIST,s Organization of ... among the first appointments made to the new ...
(Date:7/10/2014)... 2014 Smart technology emphasis grows in ... improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. (NASDAQ: ... Apple Inc. (NASDAQ: AAPL ), Visa Inc. (NYSE: ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on ... second series of 30 second spots on CNBC for its ...
(Date:7/10/2014)... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on the growing ... was interviewed on July 1 st on the Downtown ... Mr. Pereira discusses the company,s next generation smart wallet with ... Wocket™ aims to replace a traditional wallet with a new ... tells Gino he has never heard of the Wocket and ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4
... CAMBRIDGE, Mass., July 12, 2011 GNS Healthcare, ... Institute (NCI) to accelerate lung cancer research with a ... in huge data sets assembled from imaging, genetics, pathology, ... patients will respond to a given treatment. ...
... 07/07/11, Clearwater Beach, FL. New research findings ... Society for the Study of Ingestive Behavior (SSIB), the foremost ... behavior, finds that ghrelin, a natural gut hormone that stimulates ... cues to alter dopamine levels within the striatum, a critical ...
... China BGI (previously known as the Beijing Genomics Institute), ... it was among the research organizations comprising the Potato Genome ... of the tuber crop potato, published as an Advance Online ... This study marks an important milestone in Potato ( Solanum ...
Cached Biology News:GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients 2GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients 3BGI contributes whole genome sequencing and bioinformatics expertise to potato genome research 2BGI contributes whole genome sequencing and bioinformatics expertise to potato genome research 3
(Date:7/10/2014)... Ind. , July 10, 2014 /PRNewswire/ ... its use of capnography for respiratory monitoring ... group of healthcare leaders in embracing state-of-the-art ... how effectively patients are breathing and can ... occurs. By measuring the amount of carbon ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... 15, 2014 -- According to the International Atomic ... security comes from terrorists acquiring sufficient quantities of ... a crude nuclear explosive device. The IAEA also ... have involved gram-level quantities, which can be challenging ... to a new study appearing this week in ...
(Date:7/10/2014)... journal PNAS (Proceedings of the National Academy of ... sleep deprivation have a significant effect on our metabolism. ... best time of day to test for diseases such ... effectively. , Researchers from the University of Surrey and ... between sleep deprivation, body clock disruption and metabolism, and ...
Breaking Biology Technology:Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Sensitive detection method may help impede illicit nuclear trafficking 2Time of day crucial to accurately test for diseases, new research finds 2
... $50,000 planning grant from the Ewing Marion Kauffman ... plan for cross-campus entrepreneurship in a national competition among ... was selected by the Foundation to compete for further ... Entrepreneurial Initiative. , ,Provost Peter Spear and School ...
... complaints of poor service from Wisconsin customers two years ago ... ,Paul La Schiazza, president of SBC's Wisconsin division said that ... was not a small local company, but a large corporation ... SBC Communications Inc. announced that SBC Ameritech of Wisconsin would ...
... offer an integrated PAC (picture achieving and communications) and ... of hospitals and imaging centers. , ,"The acquisition ... our evolution as a healthcare software and services company ... market," said Rich Linden, Merge eFilm president and CEO. ...
Cached Biology Technology:UW-Madison Receives Grant to Develop Entrepreneurship Proposal 2SBC is Here to Stay 2Merge eFilm to buy Ohio firm in $14M Deal 2Merge eFilm to buy Ohio firm in $14M Deal 3
... PolarScreen Progesterone Receptor (PR) Competitor Assay ... screening novel progesterone receptor binding compounds ... assay utilizes a fusion of glutathione ... of human progesterone receptor [PR-LBD(GST)] and ...
... acid analysis standard is a ... salts; molecular weights range from ... is provided for use with ... the organic acid analysis kit ...
... Imaging Systems group announces the availability ... Imaging Systems, featuring high resolution cooled ... luminescence, radiographic and chromogenic imaging capability. ... and 10x optical zoom lens provides ...
... The RapidVUE is a particle shape and ... has been designed with the utmost simplicity in ... sample delivery module and an optical bench. The ... allows for easy upgrade for different applications such ...
Biology Products: