Navigation Links
Sun exposure early in life linked to specific skin cancer gene mutation

Skin cancers often contain different gene mutations, but just how these mutations contribute to the cause of melanomas has been a mystery.

A new clue comes from scientists at the University of North Carolina at Chapel Hill Schools of Medicine and Public Health. Their research indicates that early life sun exposure, from birth to 20 years old, may specifically increase the risk of melanomas with BRAF gene mutations. A different mutation, on the NRAS gene, was found in patients who had sun exposure later in life (between ages 50 to 60 years old). The results indicate that different subtypes of melanoma are associated with different risk factors

"The findings suggest that melanoma subtypes have different causes. This is important for learning more about how to prevent and treat skin cancer," said Dr. Nancy Thomas, associate professor of dermatology in the UNC School of Medicine, a member of the UNC Lineberger Comprehensive Cancer Center and lead author of the study. This finding is expected to strengthen current recommendations to protect children from sun exposure in order to prevent melanoma, Thomas said.

The study, published in the May 2007 edition of the journal Cancer Epidemiology Biomarkers and Prevention, presents some of the first data to link early life sunlight exposure to a specific mutation in melanomas.

Researchers interviewed 214 melanoma patients in North Carolina about their risk factors for melanoma and about the various places they had lived. Each patient's UV sun exposure was estimated from their residential history and satellite-base measurements. DNA from the patients' melanomas was then analyzed for mutations.

Patients with melanomas that contained the BRAF mutation, found in about half of all melanomas, were more likely to report high levels of sun exposure before age 20. People with the NRAS mutation were more likely to have had high exposure between the ages of 50 and 60. About 15 percent of me lanomas contain the NRAS mutation.

The findings come from the initial phase of an ongoing study that will ultimately include more than 1,000 patients from the U.S. and Australia. The research was funded by the Dermatology Foundation, the National Cancer Institute and the UNC Lineberger Cancer Center.


Source:University of North Carolina School of Medicine

Related biology news :

1. Any exposure to tobacco smoke during pregnancy is risky
2. Scalpel-free surgery could reduce risk of HIV and hepatitis exposure for health care workers
3. Prenatal exposure to famine increases risk of schizophrenia
4. Prenatal exposure to marine toxin causes lasting damage
5. Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
6. Prenatal nicotine exposure reduces breathing response of newborns...
7. Nicotine exposure during development leads to hearing problems
8. Bird brains shrink from exposure to contaminants
9. Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
10. Solvent exposure linked to birth defects in babies of male painters
11. Early exposure to indoor fungus molecules may protect infants against future allergies

Post Your Comments:

(Date:11/19/2015)... Nov. 19, 2015  Based on its in-depth analysis ... recognizes BIO-key with the 2015 Global Frost & Sullivan ... & Sullivan presents this award to the company that ... the needs of the market it serves. The award ... and expands on customer base demands, the overall impact ...
(Date:11/17/2015)... 2015 Paris , ... --> Paris , qui s,est tenu ... le leader de l,innovation biométrique, a inventé le premier ... empreintes sur la même surface de balayage. Jusqu,ici, deux ... pour les empreintes digitales. Désormais, un seul scanner est ...
(Date:11/12/2015)... 2015  Arxspan has entered into an agreement ... for use of its ArxLab cloud-based suite of ... partnership will support the institute,s efforts to electronically ... information internally and with external collaborators. The ArxLab ... the Institute,s electronic laboratory notebook, compound and assay ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica Richman and Zachary Apte, ... their initial angel funding process. Now, they are paying it forward to other ... stage investments in the microbiome space. In this, they join other successful ...
(Date:11/24/2015)... Therapeutics, Inc. (NASDAQ: HALO ) will be presenting at the ... on Wednesday, December 2 at 9:30 a.m. ET/6:30 a.m. PT . ... a corporate overview. th Annual Oppenheimer Healthcare Conference ... a.m. PT . Jim Mazzola , vice president of ... --> th Annual Oppenheimer Healthcare Conference in ...
(Date:11/24/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) (the ... the Toronto Stock Exchange, confirms that as of the ... developments that would cause the recent movements in the ... --> About Aeterna Zentaris Inc. ... Aeterna Zentaris is a specialty biopharmaceutical company engaged in ...
(Date:11/24/2015)... ... November 24, 2015 , ... The Academy of Model Aeronautics (AMA), led ... also known as Multirotor Grand Prix, to represent the First–Person View (FPV) racing community. ... members have embraced this type of racing and several new model aviation pilots have ...
Breaking Biology Technology: