Navigation Links
Successful cell engineering may lead to mad cow prevention, say researchers

Researchers at Texas A&M University have successfully "knocked down" the expression of possible disease-causing genes in a cloned goat fetus, perhaps paving the way for breeding disease resistance in other animals, even those genes that might cause bovine spongiform encephalopathy (BSE), commonly known as Mad Cow Disease.

Researchers Mark Westhusin and Charles Long in Texas A&M's College of Veterinary Medicine & Biomedical Sciences, working with fellow scientists Greg Hannon, Michael Golding and Michelle Carmell at the Howard Hughes Medical Institute's Cold Spring Harbor Laboratory, successfully utilized genetic engineering to produce a goat cell line in which the gene encoding for prion protein (PrP) was targeted for silencing by a process known as RNA interference. They then utilized these cells for nuclear transfer to produce a cloned, transgenic goat fetus which exhibited a greater than 90 percent knock down of PrP. Previous studies involving mice in which the PrP gene has been silenced have demonstrated the animals to be resistant to prion-mediated diseases such as BSE.

Their work is published in the current Proceedings of the National Academy of Sciences.

Their success raises the possibility of introducing the same technology into cattle to prevent numerous diseases. "The exciting part is that we may be able to use this technology to prevent other diseases from ever starting," Westhusin explains.

"We were able to knock down the genes that are involved with diseases in goats. In cattle, the disease that would most likely be targeted would be BSE, although there are numerous other genes that could be targeted to produce animals resistant to a variety of diseases. Moreover, the success raises possibilities to develop similar disease resistance strategies in other animal species," Westhusin adds.

BSE, or Mad Cow Disease, is a fatal brain-wasting disease first identified in the United Kingdom in 1986. B SE affects a cow's nervous system and causes the animal to lose much of its movement before it eventually dies.

More than 180,000 cases of BSE have been confirmed worldwide, including recent cases in the United States. The disease can be passed to humans, and more than 100 such cases have been confirmed, most of those in England.

"The next step is to try and avoid the cloning process - to skip that step if possible in developing the disease resistant animals," Westhusin says. "That's where more research is going to be needed and where the process goes from here."

Westhusin has been involved in several cloning "firsts," among them the first cloning of a cat in 2002 and a white tailed deer in 2004.


'"/>

Source:Texas A&M University


Related biology news :

1. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
2. Visceral Leishmaniasis: Successful Vaccine Trial In Dogs
3. Penn Surgeons Use Completely Robotic Surgery to Successfully Treat Prostate Cancer
4. Successful transplantation from pig embryos to mice
5. Successful lung cancer surgery not enough to break nicotine dependence in many smokers
6. U-M scientist to talk about tissue engineering at AAAS
7. Supercomputer Dedicated To Bioengineering, Computational Biology Installed
8. UCSD medical/bioengineering reseachers show titanium debris satobtage artificial joints
9. Disease diagnosis, bioengineering covered at state nano summit
10. New University of Toronto research a pore excuse for engineering
11. Genome archaeology illuminates the genetic engineering debate
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
(Date:3/15/2016)... -- --> --> According ... "Digital Door Lock Systems Market - Global Industry Analysis, Size, ... digital door lock systems market in terms of revenue was ... to grow at a CAGR of 31.8% during the period ... (MSMEs) across the world and high industrial activity driving inclusive ...
(Date:3/11/2016)... PUNE, India , March 11, 2016 ... to a new market research report "Image Recognition Market ... by Application (Marketing and Advertising), by Deployment Type (On-Premises ... Global Forecast To 2022", published by MarketsandMarkets, the global ... in 2015 to USD 29.98 Billion by 2020, at ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... ... and Drug Administration (FDA) has granted the company’s orphan drug designation request covering ... orphan drug designation granted by the FDA. , Spinocerebellar ataxia is a ...
(Date:5/24/2016)... , ... May 24, 2016 , ... Last week, Callan ... corporate executives and entrepreneurs, held The Future of San Diego Life Science event at ... Diego life science community attended the event with speakers Dr. Rich Heyman, former CEO ...
(Date:5/23/2016)... ... 23, 2016 , ... PrecisionAg® Media has released its latest ... The paper outlines the key trends that are creating both opportunities and challenges ... lot of highs and lows as the precision agriculture market has grown and ...
(Date:5/23/2016)... and LONDON , May 23, 2016 /PRNewswire/ ... See Frontage Boost Efficiency by 40% - Frontage Implement ... - Frontage Enforce Quality, Compliance and Traceability Within the Bioanalytical lab ... labs in the United States and ... to be deployed across its laboratory facilities. In addition to serving ...
Breaking Biology Technology: