Navigation Links
Study uncovers placental microtransfusions lead to transmission of AIDS virus during childbirth

medicine at the University of Melbourne.

The study involved measuring -- in umbilical cord blood samples -- a protein known as placental alkaline phosphatase as an indicator of maternal-fetal microtransfusion.

"This enzyme, made in the placenta, is very big -- usually too big to pass through the natural barrier that protects babies from disease-causing organisms mothers sometimes carry before birth," Meshnick said. "We figured that if we found it in blood from the umbilical cord, which links the placenta to the baby, that would be an indication of mixing, that something tore in the placenta and leaked the mothers' virus-contaminated blood to the infant."

Researchers then compared what they found in cord blood to whether or not infants were infected with HIV, he said.

"We looked for a statistical relationship between the presence of the enzyme and the risk of infection in the babies," Meshnick said. "We found a very strong correlation between the enzyme and the risk of infection."

It appears that transmission of the virus occurs during labor -- when contractions occur -- rather than during passage of the baby through the birth canal, he said.

"It has been known for a long time that HIV-infected women who undergo caesarean section before they go into labor do not transmit the virus, whereas those who undergo emergency C-sections after they go into labor do transmit it," Meshnick said. "What we saw was consistent with this. It looks like direct mother-to-child blood mixing occurring during labor leads to infection."

The new findings indicate that intervening just before birth by such suggested methods as sanitizing the birth canal may not work, he said. A better alternative might be to have pregnant women start taking anti-retrovirals before going into labor.


'"/>

Source:University of North Carolina at Chapel Hill


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
(Date:4/8/2015)... CHARLOTTE, N.C. , April 8, 2015 /PRNewswire/ ... technology solutions and services, and Morpho, a leading ... in partnership to produce the market,s most advanced ... Infinisource,s iSolved NXG time clock is setting ... attendance and labor data for the small and ...
(Date:4/2/2015)... April 2, 2015 At its 2015 ACMG ... City , the American College of Medical Genetics ... directors to its Board.  Members of the ACMG Board ... for forming and advancing its policies and programs. ACMG ... "It,s an eventful time in medical genetics ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... from the Wildlife Conservation Society and other groups have ... exposure to stress factors, including high temperatures, ultra-violet radiation, ... as temperature variability and tidal dynamics. The study, ... the world,s most important coral reefs by identifying reef ...
... Although phosphorus is an essential nutrient for all ... can cause water quality problems in rivers, lakes, ... aquatic ecosystems are often associated with human activities ... urban development. However, relationships between specific human sources ...
... , This release is available in Spanish ... scientist is trying to learn what is causing the decline ... species that can serve as the next generation of greenhouse ... of native plants and are used to pollinate greenhouse crops ...
Cached Biology News:Worldwide map identifies important coral reefs exposed to stress 2Worldwide map identifies important coral reefs exposed to stress 3Urban impacts on phosphorus in streams 2The flight of the bumble bee: Why are they disappearing? 2
(Date:5/21/2015)... 21, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or ... that develops and commercializes proprietary technologies and products for ... results for the second fiscal quarter ended March 31, ... continued to advance business with our existing customers and ... President and CEO of SQI. "The delivery of a ...
(Date:5/21/2015)... May 21, 2015  Prima Biomed Ltd. (NASDAQ: ... striving to become a leader in the development of ... that the final CVac data from the Phase II ... trend for a clinically meaningful improvement in Overall Survival ... patients. In the group of second remission ...
(Date:5/21/2015)... 2015 W. R. Grace & ... in Worms, Germany has received good manufacturing practice ... the International Pharmaceutical Excipient Council (IPEC) Foundation. ... its SYLOID® FP brand of pharmaceutical grade excipient ... the Curtis Bay, Maryland (USA) and Sorocaba, Brazil ...
(Date:5/21/2015)... May 20, 2015 Research and Markets ... of the "2015 Global Survey on Flow ... The primary goal of this research ... instruments and reagents. Key information the survey seeks ... of flow cytometers, predominantly used applications for flow ...
Breaking Biology Technology:SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Correction Continues after Big Move - BrokerBank Securities, Inc. 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Global Survey on Flow Cytometry Adoption Trends 2015 2
... in the Diagnosis of Uncertain ... ... Pathwork Diagnostics, Inc.,a genomics-based diagnostics company focused on oncology, today announced,the ... Diagnostics Laboratory. The new test aids in the diagnosis of,tumors of ...
... Renovis, Inc.,(Nasdaq: RNVS ), today announced that Glass ... ISS/Risk Metrics in recommending that Renovis,stockholders vote "FOR" the ... the Special Stockholders Meeting scheduled for May,1, 2008. In ... will be,converted into the right to receive the equivalent ...
... ABBOTT PARK, Ill. and ST. PAUL, ... MD will promote and distribute Abbott,s ... ). Smiths Medical MD is the ... http://www.smiths-medical.com/markets/diabetes/ ) and the Deltec Cozmo,insulin ...
Cached Biology Technology:Pathwork(R) Diagnostics Launches Genomics-Based Test For Hard-To-Identify Tumors Through Its CLIA-Certified Laboratory 2Pathwork(R) Diagnostics Launches Genomics-Based Test For Hard-To-Identify Tumors Through Its CLIA-Certified Laboratory 3Glass Lewis & Co. Recommends Renovis Shareholders Vote For Merger With Evotec 2Glass Lewis & Co. Recommends Renovis Shareholders Vote For Merger With Evotec 3Smiths Medical to Promote and Distribute Abbott's FreeStyle Navigator Continuous Glucose Monitoring System 2Smiths Medical to Promote and Distribute Abbott's FreeStyle Navigator Continuous Glucose Monitoring System 3Smiths Medical to Promote and Distribute Abbott's FreeStyle Navigator Continuous Glucose Monitoring System 4
Glucagon-like peptide-1 (GLP-1 (1-36) amide)...
Complement factor B (human)...
... kinase) signal transduction cascade is one ... in mammals. JNK pathway activation occurs ... associated with the nuclear accumulation of ... the immune response, cellular proliferation, oncogenic ...
... near- and far-infrared range FT-IR spectrometers give ... their class. Yet all this comes at ... throughput: Having a larger and faster ... other conventional FT-IRs provides 300%,larger solid angle ...
Biology Products: