Navigation Links
Study uncovers a lethal secret of 1918 influenza virus

se pandemics."

By infecting monkeys with the virus, the team was able to show that the 1918 virus prompted a deadly respiratory infection that echoed historical accounts of how the disease claimed its victims.

Importantly, the new work shows that infection with the virus prompted an immune response that seems to derail the body's typical reaction to viral infection and instead unleashes an attack by the immune system on the lungs. As immune cells attack the respiratory system, the lungs fill with fluid and victims, in essence, drown. The mechanisms that contribute to the lethality of the virus were uncovered by University of Washington researchers using functional genomics, a technique in which researchers analyze the gene functions and interactions. Learning more about the virulence mechanisms of the 1918 flu virus may help researchers understand how to keep the virus from causing such a severe immune response.

"This study in macaques, combined with our earlier research showing the host response in mice infected with the 1918 flu, suggests that the host immune response is out of control in animals infected with the virus," said Michael G. Katze, professor of microbiology at the University of Washington in Seattle, who led the functional genomics portion of the new study and led the previous mouse-based study. "Our analysis revealed potential mechanisms of virulence, which we hope will help us develop novel antiviral strategies to both outwit the virus and moderate the host immune response."

The same excessive immune reaction is characteristic of the deadly complications of H5N1 avian influenza, the strain of bird flu present in Asia and which has claimed nearly 150 human lives but has not yet shown a capacity to spread easily among people.

"What we see with the 1918 virus in infected monkeys is also what we see with H5N1 viruses," Kawaoka says, suggesting that the ability to modulate immune response may be a shared fe
'"/>

Source:University of Wisconsin-Madison


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study uncovers lethal secret influenza virus

(Date:7/10/2014)... in the West African nation Burkina Faso today ... Sayana Press has the potential to increase access ... system and in communities by combining a lower-dose ... medroxyprogesterone acetate)with the BD Uniject injection system. , ... countries expected to begin introducing Sayana Press in ...
(Date:7/9/2014)... healthy women differ from bacteria in women with ... from Loyola University Chicago Stritch School of Medicine. ... in the American Society for Microbiology,s online journal ... play a role in female urinary health. , ... poorly understood, condition with symptoms similar to urinary ...
(Date:7/9/2014)... Cancer Research Centre (CNIO) have discovered that NANOG, an ... division in stratified epitheliathose that form part of the ... the vaginain adult organisms. According to the conclusions of ... , this factor could also play a role in ... the oesophagus and skin. , The pluripotency factor NANOG ...
Breaking Biology News(10 mins):Injectable contraceptive launched in Burkina Faso to expand choice and address unmet need 2Injectable contraceptive launched in Burkina Faso to expand choice and address unmet need 3CNIO scientists discover that pluripotency factor NANOG is also active in adult organisms 2
... the limits of life in extreme environments, scientists have discovered ... an Antarctic lake sealed under more than 65 feet of ... the Proceedings of the National Academy of Sciences , ... been isolated from the surface environment -- and external sources ...
... Johns Hopkins researchers report concrete steps in the use of ... drugs. Their success highlights a pathway toward faster, cheaper drug ... to pre-test a therapy,s safety and effectiveness on cultured clones ... in an article published November 25 on the website of ...
... the first time that marine algae can be just as ... scientists genetically engineered marine algae to produce five different kinds ... used could be employed to enhance the yield of petroleum-like ... in a paper published online in the current issue of ...
Cached Biology News:UIC scientists find ancient microbes in salty, ice-sealed Antarctic lake 2Study advances use of stem cells in personalized medicine 2Bioengineered marine algae expands environments where biofuels can be produced 2
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... seasoned management team and Board, which launched the company’s ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, ... Strategy. In this role, Michelle will work with current and ... the development of iLab products. Her main goal will be ... the scientific community by offering the most advanced, user-friendly, and ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), a ... for patients, physicians, the biopharmaceutical industry, regulators, payers, ... signing of a three-year Research Collaboration Agreement (RCA) ... This initiative is designed to generate disruptive ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental products, has ... arch impressions on its dental blog. , Titled ... serves up a list of tips to help dentists best ... David Little as he crafts a porcelain crown using Kerr’s ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... PAREXEL International Corporation (Nasdaq: PRXL ) will ... January 31, 2011 after the close of the stock market. ... www.PAREXEL.com and on the PR Newswire website at ... and live webcast at 10:00 a.m. EST on Tuesday, February ...
... 2011 Advanced Pain Remedies (APR), a subsidiary of ... has been received, to advance its lead development candidate, ... targeting of specific cell types to manipulate them for ... million grant from the National Cancer Institute (NCI). Advanced ...
... CITY, Kan., Jan. 7, 2011 Aratana Therapeutics, a newly-formed ... animal health industry, today announced that it has closed a ... Avalon Ventures. "At Aratana, we will be focused ... them in new ways to treat and care for animals," ...
Cached Biology Technology:PAREXEL Announces Date of Second Quarter Fiscal Year 2011 Earnings Release and Conference Call 2Advanced Pain Remedies, a Subsidiary of Cato BioVentures, Announces a Three Million Dollar Award from the National Cancer Institute for SP-SAP 2Advanced Pain Remedies, a Subsidiary of Cato BioVentures, Announces a Three Million Dollar Award from the National Cancer Institute for SP-SAP 3
... of SYBR Green I or FAM in ... fluorophores in the second channel including ... a multitude of applications such as RT-qPCR ... offers precision thermal control and a temperature ...
... identification and library manager ... that adds capabilities for ... identification of unknowns against ... of the same taxon ...
Fingerprinting II comparative quantification and polymorphism analysis is an optional module that adds comparative quantification and polymorphism analysis functions to the Fingerprinting II Basic so...
... or for use in an automated line. ... disposable manifold provides greater ease, speed, convenience, ... StatMatic II can be connected to a ... fill a microplate with one-handed operation -- ...
Biology Products: