Navigation Links
Study shows how herpes infects cornea, evades immune cells

Herpes virus has an unusual strategy for infecting cornea cells that may also explain how it evades the immune system, according to a study by researchers at the University of Illinois at Chicago College of Medicine.

The study appears in the Sept. 25 issue of the Journal of Cell Biology.

Both strains of the herpes virus -- HSV-1, the strain that causes cold sores on the mouth, and HSV-2, genital herpes -- can infect the cornea, the clear, domed surface that forms the eye's outermost layer. Ocular herpes is the leading cause of infectious blindness in the United States, with 50,000 new or recurring cases each year.

In about one quarter of cases, the virus penetrates the first layer of the cornea to infect an inner layer, the stroma, making the disease much more difficult to treat.

Effective treatment is hampered by poor understanding of how the virus infects the stroma, says Deepak Shukla, assistant professor of ophthalmology and visual science and microbiology and immunology, and senior author of the paper. In their study, he and his coworkers determined that the HSV-1 virus enters stroma cells in a process similar to the way bacteria, viruses and other foreign invaders are engulfed by immune cells called phagocytes.

"In the electron microscope pictures, it looks like the stroma cells form long arms that reach out and collect the virus particles, and then wrap around them, forming a sac, and bring them into the cell body," Shukla said.

In phagocytes, ingested foreign particles are destroyed in the sacs, which are highly acidic. But even though the sacs formed by the stroma cells were similar to the phagocyte's sacs, Shukla said, the envelope containing the herpes virus genome emerges from the sac undamaged and able to infect the cell. "This raises the interesting possibility that herpes may be able to evade the immune system defenses in the same way," he said.

"Understanding herpes' unusual pathway for infe cting the stroma cells opens up new strategies for developing therapies against this potentially blinding disease and has implications for understanding other herpes virus infections," Shukla said.


Source:University of Illinois at Chicago

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:

(Date:11/11/2015)... MINNETONKA, Minn. , Nov. 11, 2015   MedNet ... the entire spectrum of clinical research, is pleased to announce ... Partnerships in Clinical Trials (PCT) event, to be held ... will be able to view live demonstrations of ... platform, and learn how iMedNet has been able ...
(Date:11/4/2015)... November 4, 2015 --> ... report published by Transparency Market Research "Home Security Solutions Market ... Forecast 2015 - 2022", the global home security solutions market is ... by 2022. The market is estimated to expand at ... 2015 to 2022. Rising security needs among customers at ...
(Date:10/29/2015)... , Oct. 29, 2015  Rubicon Genomics, ... for U.S. distribution of its DNA library preparation ... and Rubicon,s new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq ... the preparation of NGS libraries for liquid biopsies--the ... diagnostic and prognostic applications in cancer and other ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... --> ... 2020 report analyzes that automating biobanking workflow will ... long-term samples, minimizing manual errors, improving the workflow ... errors such as mislabeling or inaccurate sample barcoding ... a vital role in blood fractionation, DNA extraction, ...
(Date:11/25/2015)... ANGELES and HOLLISTON, Mass. ... Technology, Inc. (Nasdaq: HART ), a biotechnology company ... that CEO Jim McGorry will present at ... December 1, 2015 at 2:30 p.m. PT. The presentation ... below) for 30 days. Management will also be available ...
(Date:11/25/2015)... 25, 2015 Orexigen® Therapeutics, Inc. (Nasdaq: ... a fireside chat discussion at the Piper Jaffray 27th ... . The discussion is scheduled for Wednesday, December 2, ... .  A replay will be available for 14 days ... , Julie NormartVP, Corporate Communications and Business Development , ...
(Date:11/24/2015)... ... November 24, 2015 , ... The United States Golf Association (USGA) today ... Green Section Award. Presented annually since 1961, the USGA Green Section Award recognizes an ... turfgrass. , Clarke, of Iselin, N.J., is an extension specialist of turfgrass ...
Breaking Biology Technology: