Navigation Links
Study reveals dramatic difference between breast cancers in US and Africa

A study comparing, for the first time, breast cancers from Nigeria, Senegal and North America has found that women of African ancestry are more likely to be diagnosed with a more virulent form of the disease than women of European ancestry.

Researchers from the University of Chicago, working with colleagues at the University of Calabar in Nigeria and the University of North Carolina, found that breast cancers in African women produce a different pattern of gene expression. Tumors from African women -- from three locations in Nigeria and one in Senegal -- are more likely to originate from a different group of cells within the breast and often do not present the molecular targets that form the basis of many standard therapies.

"We have known for a long time that breast cancer is not one disease and that it may be somehow different in Africa," said study author Funmi Olopade, M.D., professor of medicine and director of the Center for Clinical Cancer Genetics at the University of Chicago. "But there was no real sense of how much of that was biology and how much was environment. Now we have clear evidence that nature plays an important role. These tumors are biologically quite different in ways that make this a worse disease."

"The discovery means we have to rethink how soon and how often we screen for breast cancer in women at risk for the most aggressive type of breast cancer, as well as how we prevent it and how we treat it," she added. "The guidelines were developed based on our deep knowledge of breast cancer in older women of European ancestry, but our results mean that much of the U.S. and European data simply do not apply to the types of breast cancer we most commonly see in African women."

The researchers studied the pattern of gene expression -- a measure of which genes were turned on and active -- in breast cancer tissue from 378 women in Nigeria and Senegal. They compared the results with a database of breast cancer tissue from
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:7/23/2014)... -- BCC Research ( www.bccresearch.com ... AND TECHNOLOGIES FOR SENSORS , the global market for ... nearly $154.4 billion by 2020, with a five-year compound ... and level sensors segment is moving at a significant ... , Sensors have become indispensable to many ...
(Date:7/23/2014)... news release is available in German . ... varying sensory modalities for orientation, some of which might ... example take the polarization pattern produced by sunlight in ... from the Max Planck Institute for Ornithology in Seewiesen, ... from Israel that a night active mammal, the greater ...
(Date:7/23/2014)... are packed with healthful compounds, and now lab tests ... as prescription anti-diabetic medication, scientists report. In their new ... Food Chemistry , they found that how the herbs ... which compounds contribute the most to this promising trait. ... that in 2012, type-2 diabetes affected more than 8 ...
Breaking Biology News(10 mins):Global Market for Sensors to Reach Nearly $154.4 Billion in 2020; Image Sensors Moving at 11.7% 2Global Market for Sensors to Reach Nearly $154.4 Billion in 2020; Image Sensors Moving at 11.7% 3Bats use the evening sky's polarization pattern for orientation 2
... papers appearing in the prestigioous journal Science ... Besansky, a professor of biological sciences and a member ... University of Notre Dame, provided evidence that Anopheles gambiae, ... the malaria parasite in Sub-Saharan Africa, is evolving into ...
... a mouse that can run on a treadmill twice ... supply of acetylcholine, the neurotransmitter essential for muscle contraction., ... could lead to new treatments for neuromuscular disorders such ... fail to reach the muscles, said Randy Blakely, Ph.D., ...
... While Yellowstone,s celebrated bison may be among the ... habits and increasing numbers have raised questions about the ... the National Park Service has partnered with Syracuse University ... climate change and herbivores on the park,s grasslands over ...
Cached Biology News:New study examines immunity in emerging species of a major mosquito carrer of malaria 2Boosting supply of key brain chemical reduces fatigue in mice 2SU biologist partners with National Park Service to study bison grazing in Yellowstone 2SU biologist partners with National Park Service to study bison grazing in Yellowstone 3
(Date:7/23/2014)... LAS VEGAS , July 23, 2014  GrowBLOX Sciences, ... announced today that it is filing for two medical marijuana ... These locations are in addition to the Clark ... received a special use permit, as previously announced.  ... pleased to be submitting two new applications for dispensaries in ...
(Date:7/23/2014)... N.J. (PRWEB) July 23, 2014 ... Comprehensive Cancer Center has joined its Strategic Alliance ... Strategic Alliance Partnership program, UNC Lineberger will have ... to raise awareness of its cutting-edge research initiatives, ... from UNC Lineberger will work with OncLive to ...
(Date:7/22/2014)... (PR Web) July 21, 2014 (PRWEB) July 23, ... for Biomaterials, at Rutgers University. , The ... and ideas across the full spectrum of scientists ... selected research and development topics that represent the ... have been programmed to:,     Provide ...
(Date:7/22/2014)... solution of rod-shaped metal nanoparticles in water with ultrasound ... drill bits. Why? No one yet knows exactly. But ... (NIST) have clocked their speedand it,s fast. At up ... times faster than any nanoscale object submerged in liquid ... has opened up the possibility that they could be ...
Breaking Biology Technology:GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 2GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 3OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 2OncLive Expands Its Strategic Alliance Partnership Program With the Addition of UNC Lineberger Comprehensive Cancer Center 3The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2NIST shows ultrasonically propelled nanorods spin dizzyingly fast 2
... BELMONT, Calif., March 5, 2012  Phalanx Biotech Group, ... the OneArray® line of open-platform microarrays for whole ... several new product launches in 2011, Phalanx Biotech ... markets.  "2011 proved to be a very busy ...
... scientists at the U.S. Department of Energy,s Lawrence Berkeley National ... of gold mere nanometers (billionths of a meter) thick were ... to cool. They watched in surprise as peculiar features expanded ... settling into circles surrounded by irregular blisters. The ...
... an earthquake and tsunami hit Japan on March ... country,s failures in disaster planning and crisis management for ... The article, out now in the Bulletin of ... agencies were thoroughly unprepared for the cascading nuclear disaster, ...
Cached Biology Technology:Phalanx Biotech Group Reports Robust Revenue Growth in 2011 2Solved: The mystery of the nanoscale crop circles 2Solved: The mystery of the nanoscale crop circles 3Solved: The mystery of the nanoscale crop circles 4Fukushima 1 year on: Poor planning hampered Fukushima response 2Fukushima 1 year on: Poor planning hampered Fukushima response 3
... cells were cultured in DMEM with 4 mM ... growth. In order to keep the antigens ... acetone-methanol. The cells are arrayed on a ... wells surface specifically treated to enhance cellular attachment ...
... The CopyControl™ vector can be induced prior ... vectors provide the stability of single-copy BACs ... or other cloning vectors. The kits provide ... reagents, insert size screening system) necessary to ...
...
... General description: The "egg crate" style ... any Costar flat bottom strips. Linkage: This ... created to easily match Cornings product number. ... under the old Sigma-Aldrich number (Z71,456-9) or ...
Biology Products: