Navigation Links
Study reveals dramatic difference between breast cancers in US and Africa

A study comparing, for the first time, breast cancers from Nigeria, Senegal and North America has found that women of African ancestry are more likely to be diagnosed with a more virulent form of the disease than women of European ancestry.

Researchers from the University of Chicago, working with colleagues at the University of Calabar in Nigeria and the University of North Carolina, found that breast cancers in African women produce a different pattern of gene expression. Tumors from African women -- from three locations in Nigeria and one in Senegal -- are more likely to originate from a different group of cells within the breast and often do not present the molecular targets that form the basis of many standard therapies.

"We have known for a long time that breast cancer is not one disease and that it may be somehow different in Africa," said study author Funmi Olopade, M.D., professor of medicine and director of the Center for Clinical Cancer Genetics at the University of Chicago. "But there was no real sense of how much of that was biology and how much was environment. Now we have clear evidence that nature plays an important role. These tumors are biologically quite different in ways that make this a worse disease."

"The discovery means we have to rethink how soon and how often we screen for breast cancer in women at risk for the most aggressive type of breast cancer, as well as how we prevent it and how we treat it," she added. "The guidelines were developed based on our deep knowledge of breast cancer in older women of European ancestry, but our results mean that much of the U.S. and European data simply do not apply to the types of breast cancer we most commonly see in African women."

The researchers studied the pattern of gene expression -- a measure of which genes were turned on and active -- in breast cancer tissue from 378 women in Nigeria and Senegal. They compared the results with a database of breast cancer tissue from
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:9/5/2008)...nformatics will convene September 7-9 at the Stock...ging neuroinformatics field combines neuroscience ... and approaches to understanding the structure and...ied to brain disorders and diseases. With a broad ...ether experts from all disciplines contributing to...
(Date:9/5/2008)...sophisticated computer model pioneered at Princeto...d that many governments worldwide are recommending...the availability of many drugs and therapies to tr...ommend using what is known as a single first-line ... many patients. Writing in the Sept. 16 issue of t...
(Date:9/5/2008)...ding colonies of a critically endangered vulture, ...of millions to a few thousand, are too small to pr... Michigan analysis shows. , Adding wild birds to...ia, is crucial, but political and logistical barri.... Johnson. , The study was published online Augu...
(Date:9/5/2008)...ave evolved more than once, according to research ...ondon scientists. , Species of bat with the abil... evolutionary tree of life - some are more related.... This has raised the question of whether echoloca...r the fruit bats somehow lost their ability to ech...
Breaking Biology News(10 mins):INCF organizes the first congress dedicated to the emerging field of neuroinformatics 2Best way to treat malaria: Avoid using same drug for everyone, scientists say 2Best way to treat malaria: Avoid using same drug for everyone, scientists say 3Recovery efforts not enough for critically endangered Asian vulture 2Recovery efforts not enough for critically endangered Asian vulture 3Molecular evolution is echoed in bat ears 2HealthSouth Declares Dividend on 6 5 25 Series A Convertible Perpetual Preferred Stock 2109 1HealthSouth Declares Dividend on 6 5 25 Series A Convertible Perpetual Preferred Stock 2109 2Kiwa Bio Tech Completes 1st Stage of Shandong Factory Upgrading 859 1Kiwa Bio Tech Completes 1st Stage of Shandong Factory Upgrading 859 2Emphasizing the precision in precision agriculture 574 1Emphasizing the precision in precision agriculture 574 2Possible safer target for anti clotting drugs found 2102 1Possible safer target for anti clotting drugs found 2102 2
...ing that endangered California condors raised in c...ies so that the birds can once again feast on the ... centuries ago. , The researchers from Stanford Un...nclusion on the feeding behavior of modern and ear...e Nov. 7 online edition of the Proceedings of the ...
...ize itself - strengthening or weakening connection...onnections - allows it to form memories, make tran...ion on objects of interest. , This phenomenon is a...ctions where neurons communicate using chemical su... Now, for the first time, Brown University scienti...
...of food that has made them sick in the past is eno...em from eating that food again. It,s a response th...l to basic biology that it occurs in a broad range...n, quickly learn to avoid smells associated with f...d by Howard Hughes Medical Institute investigator ...
...ity centre has found that the numbers of men ?espe... donors fell sharply after 2000, almost certainly ...ould be removing the right to anonymity. , The fal...e in the numbers recruited, has prompted researche...call for urgent action to attract more volunteers ...
Other Biology News:Seal rookeries could provide a reliable food source for endangered California condors, study finds 2Seal rookeries could provide a reliable food source for endangered California condors, study finds 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 4Seal rookeries could provide a reliable food source for endangered California condors, study finds 5What can change in the brain? Electrical synapses, research shows 2Worms know bad food when they smell it 2Worms know bad food when they smell it 3Worms know bad food when they smell it 4UK sperm donor crisis 2UK sperm donor crisis 3
(Date:9/5/2008)...5 /- Gen-Probe Incorporated... will present at the Morgan,Stanley Global Healthc...2008 at approximately 2:45 p.m. Eastern Time. The ...ay be accessed through a link on the investors,sec...be.com . The webcast,will be available for 30 days...
(Date:9/5/2008)...fornia, September 5 /-, - Exchange: ...h 2008 a name change to,Fountain Healthy Aging Inc... follows the earlier,approval of the name change b...he Company., CEO, Dr Tony Jimenez said a name cha...d a completely new business plan ", Dr Jimenez we...
(Date:9/5/2008)...5 / Ondine Biopharma,Corpor...ompany developing,photodisinfection-based products...infection in the Treatment of Chronic Periodontiti... the American Academy of,Periodontology,s (AAP) an...d at the Washington State Convention and Trade Cen...
(Date:9/5/2008)...Well-Positioned to Expand Business Development Eff...al Biotech Inc., a company,focused on the developm...technologies in the spine care market, announced t...ment team as the company,s new Vice President of,S...l oversee Axial Biotech,s global efforts to,identi...
Breaking Biology Technology:Gen-Probe to Webcast Presentation at the Morgan Stanley Global Healthcare Unplugged Conference 2Immureboost Inc Announces a Change of Name to Fountain Healthy Aging Inc 2Ondine Announces Presentation of Positive Clinical Trial Results at the American Academy of Periodontology's 94th Annual Meeting 2Axial Biotech appoints new Vice President of Strategic Initiatives 2
... a series of articles on developing start-up compa..., , Madison, Wis. - In Step 1 of our Early Sta...ectual property, and in Step 2 we discussed choosi...oosing a trademark/brand name and business name. A...ou should have simultaneously made sure that this ...
...at major universities, Rebecca Eisenberg and Ar...hey are not calling for repeal of Bayh-Dole , the...patent their inventions. They are advocating an ...al discovery. , ,Eisenberg of the University of M...aced among the most vocal critics of a law that ma...
...er Sonic Foundry, Inc. has exceeded the $75 mill...as enabled it to access what CEO Rimas Buinevicius...c Foundry has set this process in motion with a r... and Exchange Commission that seeks to establish ...ave the option to sell up to 12 million shares of ...
...en, who has served as vice president of regulatory... appointed president of AT&T Wisconsin, the compan...&T for 17 years, is credited with leading AT&T Wis...cluding the company,s bid to win state approval to... company,s activities in a major wholesale pricing...
Other Biology Technology:Early Stage, Step 3: Naming the entity 2Early Stage, Step 3: Naming the entity 3Early Stage, Step 3: Naming the entity 4Professors want to tweak, not overhaul, patent law 2Professors want to tweak, not overhaul, patent law 3Sonic Foundry explores capital options 2
ZOOM® IEF Fractionator from Invitrogen
Agarose, Biotechnology grade, 500g
Clarin Mounting Medium (Permanent environmentally safe mounting medium for general histology & cytology use)
Rnase Inhibitor from Bioline
Biology Products: