Navigation Links
Study reveals details of mussels' tenacious bonds

When it comes to sticking power, marine mussels are hard to beat. They can adhere to virtually all inorganic and organic surfaces, sustaining their tenacious bonds in saltwater, including turbulent tidal environments. Little is known, however, about exactly how the bivalves achieve this amazing feat.

In a paper to be published online the week of Aug. 14 by the Proceedings of the National Academy of Sciences, a Northwestern University research team sheds new light on the adhesive strategies of mussels, information that could be used to develop adherents or repellants for use in medical implants.

This is the first-ever single molecule study to focus on the key amino acid 3,4-L-dihydroxyphenylalanine (DOPA), a tyrosine derivative that is found in high concentration in the "glue" proteins of mussels.

The researchers, led by Phillip B. Messersmith, associate professor of biomedical engineering in the McCormick School of Engineering and Applied Science, attached single DOPA amino acids to an atomic force microscope tip and measured the strength of interaction between DOPA and inorganic and organic surfaces.

They found that on an inorganic metal oxide surface DOPA interacts with the substrate by a coordinated noncovalent interaction, which is over an order of magnitude stronger than hydrogen bonding but still completely reversible.

On an organic substrate, DOPA can form even stronger, and irreversible, covalent bonds when it is oxidized by seawater. This helps to explain the remarkable versatility of mussels to adhere strongly to many different materials.

On neither substrate could tyrosine alone mimic such a strong binding interaction, which highlights that the modification of tyrosine residues to form DOPA during mussel glue processing is critical.

"Our results point the way toward new applications for our mussel mimetic polymers," said Messersmith, who has designed a versatile two-sided coating that sticks se curely to a surface and prevents cell, protein and bacterial buildup. "For example, we may be able to take advantage of the reactivity of oxidized DOPA to form covalent bonds between adhesive DOPA-containing polymers and human tissue surfaces."


Source:Northwestern University

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:

(Date:11/10/2015)... 2015  In this report, the biomarkers ... product, type, application, disease indication, and geography. ... are consumables, services, software. The type segments ... efficacy biomarkers, and validation biomarkers. The applications ... development, drug discovery and development, personalized medicine, ...
(Date:11/9/2015)... ) ... "Global Law Enforcement Biometrics Market 2015-2019" ... ) has announced the addition of ... 2015-2019" report to their offering. ... ) has announced the addition of the ...
(Date:11/4/2015)... ALBANY, New York , November 4, 2015 /PRNewswire/ ... According to a new market report published by Transparency ... Size, Share, Growth, Trends and Forecast 2015 - 2022", ... value of US$ 30.3 bn by 2022. The market ... during the forecast period from 2015 to 2022. Rising ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... PA (PRWEB) , ... November 24, 2015 , ... This ... entrepreneurs at competitive events in five states to develop and pitch their BIG ideas ... projects from each state are competing for votes to win the title of SAP's ...
(Date:11/24/2015)... November 24, 2015 SHPG ) announced today ... the Piper Jaffray 27 th Annual Healthcare Conference in ... 2015, at 8:30 a.m. EST (1:30 p.m. GMT). --> ... Officer, will participate in the Piper Jaffray 27 th Annual ... on Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. ...
(Date:11/24/2015)... Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today announced that ... 2015 at 11:00 a.m. Israel time, at the ... Yigal Allon Street, 36 th Floor, Tel Aviv, Israel ... Paneth and Izhak Tamir to the Board of Directors; ... external directors; , approval of an amendment to certain terms of ...
(Date:11/24/2015)... FRANCISCO , Nov. 24, 2015  Twist ... announced that Emily Leproust, Ph.D., Twist Bioscience chief ... Jaffray Healthcare Conference on December 1, 2015 at ... Hotel in New York City. --> ... . Twist Bioscience is on Twitter. ...
Breaking Biology Technology: