Navigation Links
Study reveals details of mussels' tenacious bonds

When it comes to sticking power, marine mussels are hard to beat. They can adhere to virtually all inorganic and organic surfaces, sustaining their tenacious bonds in saltwater, including turbulent tidal environments. Little is known, however, about exactly how the bivalves achieve this amazing feat.

In a paper to be published online the week of Aug. 14 by the Proceedings of the National Academy of Sciences, a Northwestern University research team sheds new light on the adhesive strategies of mussels, information that could be used to develop adherents or repellants for use in medical implants.

This is the first-ever single molecule study to focus on the key amino acid 3,4-L-dihydroxyphenylalanine (DOPA), a tyrosine derivative that is found in high concentration in the "glue" proteins of mussels.

The researchers, led by Phillip B. Messersmith, associate professor of biomedical engineering in the McCormick School of Engineering and Applied Science, attached single DOPA amino acids to an atomic force microscope tip and measured the strength of interaction between DOPA and inorganic and organic surfaces.

They found that on an inorganic metal oxide surface DOPA interacts with the substrate by a coordinated noncovalent interaction, which is over an order of magnitude stronger than hydrogen bonding but still completely reversible.

On an organic substrate, DOPA can form even stronger, and irreversible, covalent bonds when it is oxidized by seawater. This helps to explain the remarkable versatility of mussels to adhere strongly to many different materials.

On neither substrate could tyrosine alone mimic such a strong binding interaction, which highlights that the modification of tyrosine residues to form DOPA during mussel glue processing is critical.

"Our results point the way toward new applications for our mussel mimetic polymers," said Messersmith, who has designed a versatile two-sided coating that sticks se
'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study reveals details mussels tenacious bonds

(Date:11/21/2014)... , Nov. 20, 2014 Strict laws against ... are piloting the North American and European automotive sector ... growing, gesture recognition systems that are intuitive and able ... in the industry. New analysis from ... Recognition Market in Europe and ...
(Date:11/18/2014)... Nov. 17, 2014   News ... collaborate to develop The Partners Data Lake, an ... Partners Data Lake will allow researcher and clinicians ... treatment and the lives of patients , ... clinical activities across the Partners system, breaking down ...
(Date:11/12/2014)... 12, 2014 Crossmatch™, a leading provider of ... ® fingerprint readers have been deployed throughout Montparnasse ... Central Mexico . The bakery chain implemented the ... issues caused by employees clocking in for each other. ... readers, Montparnasse relied on paper timecards and a mechanical ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... by researchers from the University of York suggests protected ... as the iconic Acacia tree., Acacia, the thorny flat-topped ... component of ecosystem diversity. However, the researchers found that ... through the protected area network, which includes national parks, ...
... Paleontology, with its rocks and fossils, seems far removed ... dishes and embryos. Whereas paleontology strives to determine "What ... embryos to try to answer "How did it happen?" ... that benefit both fields. In the current issue ...
... could control the fungal disease that is threatening the UK,s ... at Imperial College London,s Silwood Park Campus in Berkshire and ... entered the country via ash saplings imported from the ... an estimated 100,000 diseased saplings and mature trees in the ...
Cached Biology News:Protected areas in East Africa may not be conserving iconic plants 2Protected areas in East Africa may not be conserving iconic plants 3Recent studies bring fossils and genes together to piece together evolutionary history 2Recent studies bring fossils and genes together to piece together evolutionary history 3Researchers test solution to fungal disease of ash trees 2Researchers test solution to fungal disease of ash trees 3
(Date:11/27/2014)... DUBLIN , Nov. 27, 2014 ... of the "Global Palmitic Acid Industry Report 2014" ... http://photos.prnewswire.com/prnh/20130307/600769 The Global Palmitic Acid ... on the current state of the global palmitic acid ... of the industry including definitions, classifications, applications and industry ...
(Date:11/27/2014)... November 27, 2014 First ...   Elsevier , a world-leading provider ... is pleased to announce the launch of a new ... The launch of Extreme Mechanics ... at the forefront of applied sciences such as micro ...
(Date:11/27/2014)... BELLINGHAM, Washington, and PITTSFIELD, Massachusetts, USA (PRWEB) November 26, ... pinpoint cancer cells with more accuracy, additive systems to ... improve highway safety by analyzing road conditions are among ... Awards for Photonics Innovation . The awards are sponsored ... photonics , and Photonics Media . , Winners ...
(Date:11/26/2014)... The report on the Global Smart Sensor Market in ... revenue forecasts and market trends. It expects the market ... to 2018. At the projected rate, the market is ... 2018. , Browse through the Global Smart Sensor Market ... market segmentation and in-depth analysis supported by a list ...
Breaking Biology Technology:Global Palmitic Acid Industry Report 2014 2Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 2Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 3Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 2Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 3Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 4
... , BETHESDA, Md., July 30 Micromet, ... novel, proprietary antibodies for the treatment of cancer, inflammation and ... of 14,000,000 shares of its common stock at a public ... shares are being offered by Micromet. The gross proceeds ...
... , , , ALPHARETTA, ... company, recently announced the appointment of Philip Vogt as Executive ... Vogt brings more than thirty years of pharmaceutical experience and ... Prior to this role, Vogt served as President of ...
... , NEW YORK, July 30 Stemline Therapeutics, ... of oncology compounds directed to cancer stem cell targets, today ... invited to present at the New Frontiers in Cancer Drug ... Development Week in Boston, MA. Dr. Bergstein,s presentation, entitled ...
Cached Biology Technology:Micromet Announces Pricing of Public Offering of Common Stock 2Micromet Announces Pricing of Public Offering of Common Stock 3Micromet Announces Pricing of Public Offering of Common Stock 4Stemline Therapeutics CEO to Present at IBC's New Frontiers in Cancer Drug Development Conference 2
...
Peptide-affinity Purified Polyclonal Antibody to MAML1 / Mastermind Peptide with sequence VLPTCPMAEFALPR, from N Terminus of the protein sequence according to NP_055572....
Mouse monoclonal [5H9] to RAD52 ( Abpromise for all tested applications). entrezGeneID: 5893 SwissProtID: P43351...
... of calcium binding proteins such as calmodulin and ... alpha and beta chain whereas S100B is composed ... also expressed in the antigen presenting cells such ... reticulum cells in the paracortex of lymph nodes. ...
Biology Products: