Navigation Links
Study reveals candidate targets for anti-retroviral therapeutics

The increased frequency of drug resistance in isolates of the AIDS virus, HIV, makes identification of new antiviral targets an urgent necessity. Host genes required to support the replication of HIV are a potential source of such novel targets, but relatively few appropriate target genes have been identified in animal cells thus far. A new study, conducted by Dr. Suzanne Sandmeyer and colleagues at the University of California, reports the discovery of over 100 host genes that affect the replication of a model retrovirus. Their results are reported in the May issue of Genome Research.

Many organisms harbor mobile genetic elements that are non-pathogenic molecular relatives of retroviruses. In budding yeast, these mobile elements (called Ty ?or transposable yeast ?elements) encode proteins that are homologs of retroviral proteins. The proteins encoded by Ty elements and the steps of the life cycle in yeast are similar to the proteins encoded by retroviruses and their life cycles in animal cells. Scientists believe that these simple elements in a single-celled organism are a good model for understanding how retroviruses such as HIV interact with their hosts. Yeast has previously been used as a model to help scientists understand how cancer cells replicate out of control.

The Sandmeyer laboratory, which has expertise in genetics and biochemistry, screened a collection of over 4457 mutant yeast strains representing most of the known genes in yeast. They then solicited the help of computer scientist Pierre Baldi, also at the University of California, to focus on gene functions likely to be particularly significant in the Ty3 lifecycle. Together, they developed an interactive program (GOnet) allowing them to search through large amounts of genetic and biochemical data to identify "clusters," or related groups of genes, that are most likely to affect key points in the Ty3 lifecycle. In total, they identified 130 genes that affect the replication of the retr
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:7/22/2014)... A new study that examined the survival rates ... bycatch in commercial longline fishing operations found large ... bigeye thresher, dusky, and scalloped hammerhead being the ... University of Miami (UM) Rosenstiel School of,Marine and ... Science and Policy, provides,new information to consider for ...
(Date:7/22/2014)... collaboration known as the ,1000 Bull Genomes Project, aims ... dairy cattle while also improving animal health and welfare. ... sequencing the whole genomes of 234 individual bulls whose ... are reported in the journal Nature Genetics . ... this information to reduce or eliminate hereditary diseases and ...
(Date:7/22/2014)... from the National Institute of Standards and Technology ... a dramatically improved technique for analyzing biological cells ... The new NIST technique is an advanced form ... one that delivers signals that are 10,000 times ... 100 times stronger than obtained from comparable "coherent ...
Breaking Biology News(10 mins):New study reveals vulnerability of sharks as collateral damage in commercial fishing 2Whole-genome sequencing of bulls in key beef and dairy breeds 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 3
... 2014 FASEB Science Research Conference focuses on recent ... (cobalamin), methionine and sulfur amino acid metabolism as ... health and policy, genetics, basic biology and clinical ... held every two years since 1986, attracts a ...
... This 2014 FASEB Science Research Conference will ... underlying the structure and function of membranes and ... the 2014 meeting include interfacially active peptides, membrane ... membrane protein structure, function and folding. ...
... Research Conference focuses on recent advances in understanding the ... The retina is fundamentally important for vision, and its ... and cellular mechanisms of a sensory circuit in the ... stimulus. As a result, retinal neurobiology continues ...
Cached Biology News:
(Date:7/23/2014)... DES MOINES, Iowa (PRWEB) July 23, 2014 ... will join the business as vice president of Agricultural ... from Mendel Biotechnology where he served most recently as ... brings extensive biotechnology and business leadership in the seed ... DuPont Pioneer,” said Paul E. Schickler , president ...
(Date:7/23/2014)... , July 23, 2014  Sofinnova Ventures, a ... today announced the closing of Sofinnova Venture Partners IX, ... in excess of the initial fund target of $425 ... build successful biotechnology companies. Consistent with recent funds, SVP ... later stage clinical programs, along with select investments in ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 Adult ... transplant therapies are biological, but not magical. ... seem to treat them as if they were ... as unsanctioned studies that constitute “stem cell tourism,” ... an approach to developing new regenerative medicine therapies. ...
(Date:7/22/2014)... from the National Institute of Standards and Technology ... demonstrated a new design for an atomic clock ... or a microcomb. , The microcomb clock, featured ... the new journal Optica ,* is the ... and its accurate conversion of optical frequencies to ...
Breaking Biology Technology:DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Sofinnova Raises $500 Million Biotech Venture Fund 2The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 2The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 3The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 4The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 5'Comb on a chip' powers new NIST/Caltech atomic clock design 2
... Blood America, Inc. (OTC Bulletin Board: CBAI), the umbilical ... focused on bringing the life saving potential of stem ... announce that between January 1, 2009, and today, it ... million.The Company previously said in press releases and CEO ...
... Technologies, Inc. (NYSE Alternext US: PTN) will announce its ... February 17, 2009 before the open of the U.S. ... live audio webcast hosted by its executive management team ... the results of operations in greater detail and an ...
... Nektar Therapeutics,(Nasdaq: NKTR ) will announce its ... 31, 2008 on Wednesday, February 25, 2009, after the ... chief executive,officer, will host a conference call to review ... Pacific Time (PT). , The ...
Cached Biology Technology:Cord Blood Announces $1 Million Reduction in Long Term Debt 2Palatin Technologies to Report Fiscal Year 2009 Second Quarter Results; Conference Call and Webcast on February 17, 2009 2Nektar to Announce Year-End 2008 Financial Results on Wednesday, February 25, 2009 After Close of U.S.-Based Financial Markets 2
RECK (F-20)...
The improved design and new mechanical solutions of Finnpipette Focus Multichannel Plus improves accuracy and precision.In these low volume multichannel pipettes, the super blow-out function ensures ...
NAK/TBK1 (CT) Affinity Purified Polyclonal Antibody...
... White lyophilized solid. PROTECT FROM LIGHT. PACKAGED ... of γ-secretase. Equipotently inhibits the release of ... 2.6 μM) and Aβ x-42 (ED ... cells stably transfected with the Amyloid Precursor ...
Biology Products: