Navigation Links
Study provides first look at the 'birth' of a retina cell

Scientists at the University of Michigan Kellogg Eye Center have gained new insight into the way an embryonic retina cell develops and then commits itself to a specific role. They have observed a small window of opportunity during which a cell has been designated to play a particular role, but has not yet begun to function as such.

The discovery provides a new vantage point for understanding how a healthy visual system develops. It also raises the possibility of re-directing the production of cell types as needed to stave off eye disease.

The study reports on the role of the gene regulator NRL, which was previously shown to be essential for the development of rods, the light-sensing cells required for vision.

Anand Swaroop, Ph.D., Harold F. Falls Collegiate Professor of Ophthalmology and Visual Sciences and Professor of Human Genetics, is senior author of both studies, the latest of which appears in the March 7 issue of the Proceedings of the National Academy of Sciences (PNAS).

In PNAS, Swaroop's team reports that NRL is the earliest marker of rod precursors, or cells that are fated to become rods. They achieved this unique and early view of rod development by creating a mouse model using an NRL regulatory DNA sequence to produce a protein that appears as fluorescent green when exposed to blue light. This fluorescent protein allows scientists to identify even a few cells that are destined to be rods at very early stages of development.

"For the first time we were able to see retina cells during early development, allowing us to pinpoint the exact time at which rods are 'born,'" says Swaroop. "Because the cells have been tagged, we can watch them at each step as they develop into mature and functional rods." Kellogg scientists then purified the rods at various stages and generated the profile of genes at each stage. This, for the first time, provided a handle for investigating the precise process of rod differentiation.


'"/>

Source:University of Michigan Health System


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study provides first look the birth retina cell

(Date:3/24/2015)... --  NexID Biometrics LLC, whose spoof-mitigation technology boosts ... the beginning of shipments of version 2.0 of its ... based in Potsdam, N.Y. , is ... began here today at the Walter E. Washington Convention ... SDK boosts the accuracy rate range to 96.5 to ...
(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group ... NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one ... feedback on their experience with the Wocket in multiple scenarios ... CVS, Whole Foods and other retailers, making both debit and ... Tuttle also says, "If the company meets their plans ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... have published a step by step plan to one-day end ... developing plants that produce their own fertilizer. , ... required to produce nitrogen fertilizers has pushed the world-wide cost ... says that while they are necessary for high yields, those ...
... LOVE YOU! A red splash on a toxic butterfly,s wing ... mimic the wing pattern of another toxic species in the area. ... DON,T EAT US! , Now several research teams that ... butterflies mimic each other,s red wing patterns through changes in the ...
... Irvine, Calif., July 21, 2011 For 150 years ... the best-known examples of this is how poisonous butterflies from ... in effect joining forces to warn predators, "Don,t eat us," ... international team of researchers led by Robert Reed, UC Irvine ...
Cached Biology News:An eye gene colors butterfly wings red 2UCI-led butterfly study sheds light on convergent evolution 2
(Date:4/20/2015)... , April 20, 2015  Ardelyx, Inc. ... focused on cardio-renal, gastrointestinal and metabolic diseases, today ... has joined the Company,s Board of Directors. Dr. ... board level experience, having built and led teams ... regulatory approval and into healthcare systems globally. ...
(Date:4/20/2015)... 20, 2015  Eli Lilly and Company (NYSE: ... targeted cancer therapies, reflecting Lilly,s diverse oncology pipeline, during ... 2015, held April 18-22 in Philadelphia ... Patients" is the theme of this year,s AACR meeting ... broadening its portfolio of therapies that accelerate the pace ...
(Date:4/20/2015)... DELHI , April 20, 2015 ... PI3K Targeting Supramolecular Therapeutic Using the VOLVOX Platform - ... EST  -  Supramolecular Assembly of Antibody-drug ... Cytotoxic Payload - Presented on Sunday, Apr 19, 1:00 ... leader in supramolecular therapeutic program, today announced that the ...
(Date:4/20/2015)... BEIJING, April 20, 2015 Sinovac Biotech Ltd. ... China, today announced its unaudited financial results for the ... Fourth Quarter 2014 Financial Highlights(Compared to the ... $20.3 million, a decrease of 11.4% from $22.9 million ... the stockpiling of H5N1 pandemic influenza vaccine of $0.1 ...
Breaking Biology Technology:Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 2Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 3Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 4Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 2Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 4Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 5Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 6Invictus Oncology Announces Two Posters to be Presented Describing its Platform Technology on Supramolecular Therapeutics at the American Association for Cancer Research Annual Meeting, 2015 2Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 2Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 3Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 4Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 5Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 6Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 7Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 8Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 9Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 10Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 11Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 12Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 13Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 14Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 15Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 16Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 17Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 18
... Insmed Inc. (Nasdaq CM: INSM ... host a conference call on Wednesday, May 13th at ... the first quarter 2009. Insmed intends to issue ... opens on May 13th.To participate in the live conference ...
... - Fourth Quarter 2008 Revenue Increased 28.6% to $14.1 Million, with Net, ... - 2008 Revenues Increased 23.5% to $59.1 Million vs. 2007, ... 20.1%, - 2008 Net Income Increased 13.7% to $4.1 Million ... - 2008 Cash Flow from Operations was $5.9 million, , ...
... Akaza Research will be conducting a presentation and exhibiting OpenClinica at ... Colorado Convention Center in Denver, CO. , ... Denver, ... Exhibition of the Association of Clinical Research Professionals (ACRP) will include ...
Cached Biology Technology:Insmed to Host First Quarter 2009 Conference Call 2China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 2China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 3China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 4China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 5China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 6China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 7China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 8China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 9China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 10China Yongxin Pharmaceuticals, Inc. Announces 2008 Fourth Quarter and Full Year Financial Results 11Akaza Research to Present OpenClinica at ACRP Global Conference & Exhibition 2
... system, 220-240 V, is used for biolistic particle ... employs an adjustable helium pulse to sweep DNA-, ... inner wall of a small plastic cartridge directly ... for in situ, in vitro, in vivo, and ...
... Hybridization Wash Pack provides optimized blocking ... Preparation Quality Clarifier: Ready-to-use wash solutions ... SigmaScreen(tm) APS Coated Slides for Microarrays ... Hybridization Blocking Buffer: 1L • Microarray ...
Mouse polyclonal antibody raised against a partial recombinant MHC2TA. NCBI Entrez Gene ID = 4261...
Mouse monoclonal antibody raised against a partial recombinant JRKL. NCBI Entrez Gene ID = JRKL...
Biology Products: