Navigation Links
Study pinpoints protein's role in cancer spread

Edinburgh scientists have identified the way a specific cell protein can trigger the spread of cancer. The study by researchers in the Cell Signalling Unit, University of Edinburgh Cancer Research Centre could pave the way for new drugs which limit the protein's ability to turn a normal cell cancerous.

The protein, MDM2, normally functions to control the activity of a key cancer preventing protein called p53. In some of the body's cells, the biochemical ratio between MDM2 and p53 can become unbalanced causing MDM2 to act as a cancer-promoting agent.

The project's lead investigator, Dr Kathryn Ball, a researcher at the University, explains: "One way in which MDM2 controls the p53 protein is by activating its destruction and we are interested in understanding how this happens at a biochemical level.

"In the current study, funded by Cancer Research UK, we have identified protein fragments which can bind to MDM2, inhibiting its activity. These fragments could be a good template for drugs designed to hinder the role of MDM2 in the p53 destruction pathway. We hope our findings may lead to improved treatments for a broad range of cancer types."

Welcoming the findings, Professor John Toy, medical director at Cancer Research UK, said: "p53 is a crucial protein that acts as a guardian of the normal cell. Its failure to do its job properly is associated with many types of cancer. If p53 is being destroyed by another protein in a cancer cell, then it offers an excellent target when designing new anti-cancer drugs. This research suggests MDM2 is just such a target."


'"/>

Source:University of Edinburgh


Page: 1

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study pinpoints protein role cancer spread

(Date:9/16/2014)... that make us sick can take up residence in ... cough or other troublesome symptom, according to new research ... , On average, healthy individuals carry about five ... online in BioMed Central Biology . The study ... of viruses in healthy people. , The research ...
(Date:9/16/2014)... spelled doom for the dinosaurs 66 million years ago ... much greater extent than their deciduous peers, according to ... published in the journal PLOS Biology . ... thousands of fossilized leaves of angiosperms flowering ... reconstruct the ecology of a diverse plant community thriving ...
(Date:9/16/2014)... year, a new football season and another commercial cargo ... Dragon spacecraft is scheduled to blast off to the ... the company,s fourth contracted mission to the complex. , ... of research investigations sponsored by the Center for the ... of managing the U.S. National Laboratory on the space ...
Breaking Biology News(10 mins):Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3Meteorite that doomed dinosaurs remade forests 2Meteorite that doomed dinosaurs remade forests 3Meteorite that doomed dinosaurs remade forests 4CASIS research set for launch aboard SpaceX mission to space station 2CASIS research set for launch aboard SpaceX mission to space station 3
... cells in the body could help scientists better understand how ... have found that the protein invadolysin, which is essential for ... parts of cells used to store fat. The study ... reduced amounts of fat deposits. The findings, published in ...
... National Science Foundation have awarded $824,225 in competitive funds ... million project to develop early warning forecast models for ... beaches. Funds were awarded to the University of Washington ... the interagency Ecology and Oceanography of Harmful Algal Blooms ...
... and the Swedish medical university Karolinska Institutet (KI), today ... of Philosophy (PhD) programme in Biomedical Science. This ... the latest initiative by NTU to strengthen its ties ... the high stature NTU enjoys among the leading universities ...
Cached Biology News:New project to forecast toxic algal blooms on Pacific Northwest beaches 2Nanyang Technological University and Karolinska Institutet Sweden launch new Ph.D. program 2Nanyang Technological University and Karolinska Institutet Sweden launch new Ph.D. program 3
(Date:9/16/2014)... This report analyzes the worldwide markets for Bioinformatics ... and Biocontent. The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... World. Annual estimates and forecasts are provided for the period ... for these markets. Market data and analytics are derived from ...
(Date:9/16/2014)... D.C., September 16, 2014 --The emerging field of ... to the next level, enabling the construction of ... efficient devices, individual molecules would take on the ... transistors. , A team of researchers from five ... candidate for use in small-scale electronics: a molecule ...
(Date:9/16/2014)... 16, 2014 BlueInGreen® , ... efficient method for delivering dissolved gases into liquids, ... as a manufacturer’s representative firm to its ... products for municipal water and wastewater applications in ... H2Flow was founded in 1992 and serves Quebec ...
(Date:9/16/2014)... September 16, 2014 CIRTEC Medical Systems’ ... Highley as CEO of CIRTEC. , “I am ... for the Company.” noted Brian Highley. “The company has ... sustaining strong organic growth over the past two years. ... continuing to improve and expand the services Cirtec offers ...
Breaking Biology Technology:Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23The future face of molecular electronics 2BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2
... A remarkable new invention from Tel Aviv University a ... Dew" will foil even the most determined intruder. ... on the floor of a bank, the dewdrops are a ... swathes of property. Prof. Yoram Shapira and his Tel ...
... , SANTA FE and ALBUQUERQUE, N.M., July 10 Daniel ... and only FDA-approved microsphere-enhanced collagen filler for the correction of smile ... dermal filler. Dr. Ronel has been an avid Artefill user the ... the correction of wrinkles. , , He ...
... , NEW BRUNSWICK, N.J., July 10 Johnson & ... has successfully completed its acquisition of Cougar Biotechnology, Inc., ... on oncology. , , Johnson & ... stock expired at 5 p.m. Eastern Daylight Time (EDT) ...
Cached Biology Technology:Intruder alert: Tel Aviv University's 'Smart Dew' will find you! 2Dr. Daniel Ronel Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 2Dr. Daniel Ronel Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 3Johnson & Johnson Completes Acquisition of Cougar Biotechnology 2Johnson & Johnson Completes Acquisition of Cougar Biotechnology 3
... Bioscience has over 23 years of experience ... We have made antibodies to large and ... viral antigens, and plasmid DNA-encoded antigens. We ... unique, so our hybridoma development programs are ...
... We deliversoluble protein or No Charge to ... best soluble protein results , 24 solubility ... , Powerful results on your most insoluble ... Service (SOS) uses proprietary tools and know-how ...
... Rapid-Screen cDNA Library Panels were designed for ... sets of PCRs to identify the desired ... performed in a 96-well "Master Plate," where ... clones. Having identified the positive well(s) by ...
... With the macro- and micronutrients ... Skoog (1962) and the vitamins ... al. (1968). Preparation Quantity Equivalency: ... of powder per liter of ...
Biology Products: