Navigation Links
Study outlines genetic differences between potential pandemic influenza strains

An analysis of H5N1 influenza samples in Southeast Asia shows not only how the two strains that have caused human disease are related but also that they belong to two different, distinct genetic subgroups. Researchers from the Centers for Disease Control and Prevention report their findings today at the International Conference on Emerging Infectious Diseases.

"As the virus continues its geographic expansion, it is also undergoing genetic diversity expansion," says Rebecca Garten, a researcher on the study. "Back in 2003 we only had one genetically distinct population of H5N1 with the potential to cause a human pandemic, now we have two."

Garten and her colleagues conducted a phylogenetic analysis of over 300 H5N1 virus samples taken from both avian and human sources from 2003 through the summer of 2005. They correlated the genetic makeup of viruses to the physical characteristics of viruses, including surface proteins and receptor sites, to determine where each virus should be placed on the H5N1 family tree.

Not all H5N1 viruses are genetically the same. Over the years researchers have identified different genetic groups called genotypes.

The majority of the viruses, including all the human cases, belonged to genotype Z. There were also small numbers of viruses isolated from avian populations that were genotype V or W or recently identified genotype G.

That is where the similarity between the two human strains ended. Previous research published by the World Health Organization has further classified genotype Z into subgroups called clades. In 2003 and 2004, clade 1 viruses were primarily responsible for outbreaks, including all infections in human, in Viet Nam, Cambodia and Thailand.

In 2005 a second strain of H5N1 began causing disease in humans in Indonesia. Analysis of the Indonesia strain found that it belongs to genotype Z clade 2, a subgroup of the virus that previously was not known to cause human d isease. Clade 1 and clade 2 viruses may share the same ancestor but are different and can be be likened to cousins.

What this means, says Garten, is that the pool of H5N1 candidates with the potential to cause a human influenza pandemic is getting more genetically diverse, which makes studying the virus more complex and heightens the need for increased surveillance. She expects further continued diversity in the future.

"Change is the only constant. Only time will tell whether the virus evolves or mutates in such a way that it can be transmitted from human to human efficiently," says Garten.


'"/>

Source:American Society for Microbiology


Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/16/2017)... 2017 - Against identity fraud with DERMALOG solutions "Made in Germany "  ... ... project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial contribution against ... ...
(Date:3/9/2017)... FRANCISCO and MOUNTAIN VIEW, Calif. ... , "Eating Well Made Simple," and 23andMe , ... help guide better food choices.  Zipongo can now provide ... their food preferences, health goals and biometrics, but also ... certain food choices. Zipongo,s personalized food decision ...
(Date:3/6/2017)... March 6, 2017 Mintigo , ... today announced Predictive Sales Coach TM , its ... sales intelligence into Salesforce. This unique AI application ... sales organizations with deep knowledge of their customers ... intelligent engagement. Predictive Sales Coach extends Mintigo,s existing ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... , ... April 21, 2017 , ... Having worked on ... year, Formaspace is pleased to introduce it to top lab design architects from around ... Jeff Turk and VP of Industrial Design and Engineering Greg Casey will be at ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... to nourishing a range of emerging technology-based businesses, recently earned a $77,518 grant ... location. , Founded in 2004, FITCI is Frederick’s first incubator. A non-profit ...
(Date:4/20/2017)... Maine (PRWEB) , ... April 20, 2017 , ... ... contributions to the scientific and clinical research community’s growing body of knowledge during ... 2017 in the Gracie Theatre and the adjacent Darling Atrium. During the event, ...
(Date:4/20/2017)... MD (PRWEB) , ... April 20, 2017 , ... ... the formation of a unique intellectual property (IP) sharing and commercialization model. , ... most promising inventions. A main component of this effort is bringing the IP ...
Breaking Biology Technology: