Navigation Links
Study of protein folds offers insight into metabolic evolution

database. They combined these two data sets with phylogenetic reconstructions, or family trees, of protein fold architectures in metabolism. They created a new database, called the Molecular Ancestry Network (MANET: which links these data sources into a new global network diagram of metabolic pathways.

The researchers added color, representing evolutionary age, to their diagrams of metabolic networks (for an example, see the purine metabolism network in MANET). The result is a multicolored mosaic of protein fold evolution. The mosaic shows that modern metabolic networks ?and even individual enzymes ?are composed of both very ancient and much more recent protein architectures.

"This mosaic is telling you that the new enzymes and old enzymes are together performing side by side," Caetano-Anollés said. "In some cases in the same protein you have old domains and new domains working together."

This finding supports the hypothesis that protein architectures that perform one function are often recruited to perform new tasks.

The new, global family tree of protein architecture also revealed that many metabolic protein folds are quite ancient: These architectures were found to be quite common in all the species of bacteria, animals, plants, fungi, protists and archaea the researchers analyzed.

Of 776 metabolic protein folds surveyed, 16 were found to be omnipresent, and nine of those occurred in the earliest branches of the newly constructed tree.

"These nine ancient folds represent architectures of fundamental importance undisputedly encoded in a genetic core that can be traced back to the universal ancestor of the three superkingdoms of life," the authors wrote.

The analysis also found that the most ancient metabolic protein folds are important to RNA metabolism, specifically the interconversion of the purine and pyri

Source:University of Illinois at Urbana-Champaign

Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
TAG: Study protein folds offers insight into metabolic evolution

(Date:6/25/2015)... , June 25, 2015 ... Market by Type (Swipe & Area), Technology, Material (Optical ... Healthcare, Commercial Security & Others) & Geography - ... marketsandmarkets, the said market is expected to reach ... 17.1%. Browse 76 market Tables ...
(Date:6/25/2015)...  TAKE Solutions Ltd., a global business technology solutions ... Patent and Trademark Office (USPTO) for its "Method for ... Clinical Accelerators to reduce the time taken to standardize ... without the accelerators), thus reducing time to market. ... the heart of the patented Clinical Data Standardization Process ...
(Date:6/24/2015)... -- This report provides market analysis of the Automatic ... contains an analysis of the drivers, challenges, and restraints ... the short, medium, and long term perspective landscapes. ... technology trends that currently, prevail in the market. It ... efficiently manage the increasing marine traffic and increasing importance ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2
... CAMBRIDGE, MA -- To control the three-dimensional shape of ... These devices can be implanted into patients or used ... drugs. A team of researchers from MIT, Harvard ... new element to tissue scaffolds electronic sensors. These ...
... Professional athletic field managers maintain trimmed turfgrass with ... on their grass before each game. While these fields ... have noted deteriorating turfgrass beneath repeated paint applications. ... appears in the September-October issue of Crop Science ...
... Methane is an organic carbon compound containing the fundamental ... provides an important source of energy and nutrients for ... found in abundance at the bottom of lakes., The ... has presented a study that shows methane from lakebeds ...
Cached Biology News:Merging tissue and electronics 2Athletic field paint steals spotlight from the grass it covers 2How methane becomes fish food 2
(Date:7/1/2015)... July 1, 2015  Axovant Sciences Ltd. (NYSE: ... the treatment of dementia, today announced that the ... 22 at 5:45 p.m. EDT following its presentation ... International Conference 2015 (AAIC). The ... , Dr. Lawrence Friedhoff , Chief Development ...
(Date:7/1/2015)... ... ... A newly launched business plan contest will ask startup companies from around ... sciences R&D. The Pistoia Alliance President’s Startup Challenge 2015 will see small and medium ... expert mentorship from a senior industry figure drawn from the Pistoia Alliance membership. , ...
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today that ... in Philadelphia, PA. , The presentation took place on Tuesday, June 16 ... for the development of APX3330 for the treatment of pancreatic cancer. A copy ...
(Date:7/1/2015)... July 1, 2015  UCB, a multinational biopharmaceutical ... global leader in designing, transforming, and running intelligent ... in recognition of their close collaboration in driving ... global business services (GBS) finance organization. ... clients that work together effectively to embrace the ...
Breaking Biology Technology:Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5
... Process Development Conference features presentations from industry and academic speakers ... biotechnology and chemical industries. Topics include Chemical and Process ... Quality by Design (QbD). , ... ...
... of Los Alamos researchers led by Victor Klimov has ... a real phenomenon in tiny semiconductor crystals and not ... carrier multiplication. The research, explained in a recent issue ... possibility of solar cells that create more than one ...
... Feb. 10 /PRNewswire-FirstCall/ -- ... a biopharmaceutical company focused on in-licensing, developing and ... the hospital setting, announced today that the company,s ... company,s corporate overview on Tuesday, February 17, 2009 ...
Cached Biology Technology:16th International Process Development Conference to be Held June 14-17, 2009 in Arosa, Switzerland 2Research highlights potential for improved solar cells 2Research highlights potential for improved solar cells 3Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at the Roth Capital Partners 21st Annual OC Growth Stock Conference 2