Navigation Links
Study of gene transfer for erectile dysfunction shows promise

80 years old with a mean age of 59. Six subjects were white, four were black and one was Hispanic. In half of the subjects, the cause of ED was diabetes or cardiovascular disease ?both of which can interfere with the ability of smooth muscle cells to relax.

The primary goal of the study was to determine the safety and tolerability of the new therapy. However, the results also showed that at the highest doses, men reported highly significant improvements in erectile function.

The DNA segments ?mixed into plasma ?were injected into the corpus cavernosum, expandable tissue along the length of the penis that fills with blood during erection. A variety of clinical and laboratory tests were used to assess safety. In addition, effectiveness was measured using the International Index of Erectile Function scale, a questionnaire that is commonly used to measure ED. Patient responses were validated by their partners.

Researchers identified no safety issues with the treatment. Participants who received the highest two doses had apparent sustained improvements in ED as measured by the questionnaire. The researchers said that a larger study that includes a "control" group treated with a placebo is needed to confirm the safety and effectiveness of the treatment.

Other researchers on the project were Melman, Natan Bar-Chama, M.D., with Mount Sinai School of Medicine, Andrew McCullough, M.D., with New York University School of Medicine, and Kelvin Davies, Ph.D., with Albert Einstein College of Medicine.

The technology is being developed by Ion Channel Innovations (ICI), a development stage biotechnology company, in which Christ and Melman are co-founders and directing members. The therapy is known as ion channel therapy because the proteins it targets are potassium channels, "gates" within cells critical for contraction and relaxation of smooth muscle.

At the Wake Forest Institute for Regenerative Medicine, Christ is con
'"/>

Source:Wake Forest University Baptist Medical Center


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study gene transfer for erectile dysfunction shows promise

(Date:8/28/2014)... , Aug. 28, 2014  Privacy Advocate and Senior ... Jennifer Lynch , joins the lineup of biometric and ... annual Biometrics UnPlugged Executive Summit in Tampa, ... Previously announced speakers include Steven Rahman, Director, Technology and ... Sector at Experian. The theme of this year,s event ...
(Date:8/28/2014)... production systems are good examples of complex systems. ... a networkincluding water for cooling, transport to supply ... Every step in the network chain is interconnected ... mutually dependent. A team of UK-based scientists has ... explored. The findings have been published in EPJ ...
(Date:8/28/2014)... will be built worldwide by 2050. Many of these ... bring an influx of destructive loggers, hunters and illegal ... a ,global roadmap, for prioritising road building across the ... development and environmental protection. , The map has two ... of ecosystems and a ,road-benefits, layer that estimates the ...
Breaking Biology News(10 mins):Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2Inter-dependent networks stress test 2Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3
... as phages) are among the most abundant life ... in Nature, March 2 and 12, 2008, analyse ... organosedimentary structures (sedimentary features, built by the interaction ... the living analogues of the oldest fossils on ...
... for more than a decade that a protein associated with ... they didnt know how it worked. A multidisciplinary team from ... findings could improve the design of therapeutic agents that cross ... findings appears this month in Angewandte Chemie. The TAT ...
... is available in French . , OTTAWA ... of Industry, on behalf of the Honourable Jim Prentice, ... Sciences and Engineering Research Council of Canada (NSERC), and ... Nobel Laureate John C. Polanyi is the winner of ...
Cached Biology News:Surprising discovery from first large-scale analysis of biodiversity and biogeography of viruses 2Researchers discover how stealthy HIV protein gets into cells 2Researchers discover how stealthy HIV protein gets into cells 3Dr. John Polanyi wins Canada's most prestigious science award 2
(Date:8/28/2014)... August 28, 2014 The ability for ... culture that will allow individuals to perform at the ... important for employers looking to compete in this post–recession ... embracing this trend, as the sector increasingly focuses on ... company, which will have real results on the organization's ...
(Date:8/28/2014)... Sterlitech is proud to announce that ... stable of products . These additional products ... include membrane filters with surface charges. , ... for our membrane process testing equipment, and correspondingly, a ... membranes,” explains Sterlitech President Mark Spatz. “The addition ...
(Date:8/28/2014)... Washington, USA (PRWEB) August 27, 2014 ... next month for SPIE Laser Damage 2014 ... optical materials for high-power lasers will run 14-17 September. ... society for optics and photonics . , The premier ... for understanding laser damage to optical materials will engage ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a ... SoundConnect to support their communication needs with ... web conferencing platform GlobalMeet powered by SoundConnect. The ... SoundConnect delivers award winning “results driven” business ... will be utilizing GlobalMeet powered by SoundConnect ...
Breaking Biology Technology:Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3PrimeSource Chooses SoundConnect as Collaboration Provider 2
... When the world's largest pharmaceutical company quit developing ... of Wisconsin-Madison researcher Hector DeLuca, the biochemist ... drug development firm. , ,In the beginning, it ... company, Deltanoid Pharmaceuticals , to address the ...
... Mequon, Wis. - Despite a slump in housing ... online mortgage-lending industry continues to build additions. , ,In ... in online transactions for first mortgages, mortgage refinances, home ... is poised to reach $22 million in revenue for ...
... you dropped the word sustainability in a crowd of ... have pegged you as an aging hippie, then scrambled ... to work. , ,Today, sustainability still carries some linguistic ... to talk because there's no avoiding a rational conversation. ...
Cached Biology Technology:Deltanoid presses on with drug research 2Mortgagebot builds online sales even as housing declines 2Mortgagebot builds online sales even as housing declines 3Mortgagebot builds online sales even as housing declines 4Re-engineering our economy to be sustainable and profitable 2Re-engineering our economy to be sustainable and profitable 3Re-engineering our economy to be sustainable and profitable 4