Navigation Links
Study links high levels of nitric oxide to infertility and sperm DNA damage

Iranian scientists have linked a chemical that plays an essential role in many bodily functions to sperm DNA damage and male infertility, the 22nd annual conference of the European Society of Human Reproduction heard today (Monday).

Dr Iraj Amiri, embryology laboratory director at the IVF Centre, Fatemieh Hospital, Hamadan, Iran, said: "In recent years nitric oxide (NO) has been recognised as a molecule that plays an important role in regulating the biology and physiology of the reproductive system, and we know that it can affect human sperm functions, such as motility, viability and metabolism. At low concentrations it can have a positive effect on cells, but a negative effect at high concentrations.

"In our study we discovered that there were significantly higher concentrations of nitric oxide in the seminal plasma of infertile patients than in healthy men. High concentrations of NO were significantly correlated with greater sperm DNA damage, and low concentrations of NO were significantly correlated with better sperm motility."

The researchers collected semen samples from 45 infertile patients and 70 healthy sperm donors. Most of the infertile men had low sperm counts or poor sperm motility. They measured levels of NO and used a test that can detect DNA damage and repair in individual cells (single cell gel electrophoresis (comet) assay) to determine DNA damage.

"We found that the NO levels in the infertile men were, on average, twice as high as in the fertile men," said Dr Amiri. "However, at this stage we were unable to find the cut-off point at which NO levels switched from having a positive effect to having a negative effect.

"This study indicates that infertile men have higher levels of sperm DNA damage and NO concentration in their seminal plasma compared to fertile men, and that the sperm DNA damage may be caused by the NO."

Dr Amiri said the infertile men may have had higher concentrations of NO because of ma le genital tract disease and associated factors, such as inflammation and infection, which can lead to NO over-production. There were no significant differences between the fertile and infertile men as to whether they lived in the country or in built-up, traffic-congested areas, although Dr Amiri did not rule out the role played by NO in air pollution.

"Our next step is to identify the role of some environmental factors such as air pollution, jobs, disease and smoking on over-production of NO in infertile males. We also want to find a cut-off level at which NO changes from having a beneficial effect on sperm to having a negative affect."


'"/>

Source:European Society for Human Reproduction and Embryology


Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... ... August 11, 2017 , ... “There is an ... natural alternatives to synthetic ingredients,” said Matt Hundt, President of Third Wave Bioactives. ... manufacturing presence and know-how of Biorigin will allow us to bring truly novel ...
(Date:8/10/2017)... ... 2017 , ... Teachers from three Philadelphia middle schools are ... the 16th, the University City Science Center will kick off the second FirstHand ... middle school educators an opportunity for professional development related to STEM education. ...
(Date:8/10/2017)... NC (PRWEB) , ... August 09, 2017 , ... Each ... Almost half never recover well enough to live an independent lifestyle and, even worse, ... , A new discovery by doctors at the University of California Davis Medical Center ...
(Date:8/10/2017)... ... August 09, 2017 , ... SPIE, the international ... — the Wellman Center for Photomedicine, the Manstein Lab in the Cutaneous Biology ... Laser Institute at University of California, Irvine — and the Hillenkamp family to ...
Breaking Biology Technology: