Navigation Links
Study links high levels of nitric oxide to infertility and sperm DNA damage

Iranian scientists have linked a chemical that plays an essential role in many bodily functions to sperm DNA damage and male infertility, the 22nd annual conference of the European Society of Human Reproduction heard today (Monday).

Dr Iraj Amiri, embryology laboratory director at the IVF Centre, Fatemieh Hospital, Hamadan, Iran, said: "In recent years nitric oxide (NO) has been recognised as a molecule that plays an important role in regulating the biology and physiology of the reproductive system, and we know that it can affect human sperm functions, such as motility, viability and metabolism. At low concentrations it can have a positive effect on cells, but a negative effect at high concentrations.

"In our study we discovered that there were significantly higher concentrations of nitric oxide in the seminal plasma of infertile patients than in healthy men. High concentrations of NO were significantly correlated with greater sperm DNA damage, and low concentrations of NO were significantly correlated with better sperm motility."

The researchers collected semen samples from 45 infertile patients and 70 healthy sperm donors. Most of the infertile men had low sperm counts or poor sperm motility. They measured levels of NO and used a test that can detect DNA damage and repair in individual cells (single cell gel electrophoresis (comet) assay) to determine DNA damage.

"We found that the NO levels in the infertile men were, on average, twice as high as in the fertile men," said Dr Amiri. "However, at this stage we were unable to find the cut-off point at which NO levels switched from having a positive effect to having a negative effect.

"This study indicates that infertile men have higher levels of sperm DNA damage and NO concentration in their seminal plasma compared to fertile men, and that the sperm DNA damage may be caused by the NO."

Dr Amiri said the infertile men may have had higher concentrations of NO because of ma le genital tract disease and associated factors, such as inflammation and infection, which can lead to NO over-production. There were no significant differences between the fertile and infertile men as to whether they lived in the country or in built-up, traffic-congested areas, although Dr Amiri did not rule out the role played by NO in air pollution.

"Our next step is to identify the role of some environmental factors such as air pollution, jobs, disease and smoking on over-production of NO in infertile males. We also want to find a cut-off level at which NO changes from having a beneficial effect on sperm to having a negative affect."


Source:European Society for Human Reproduction and Embryology

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:

(Date:11/19/2015)... -- Although some 350 companies are actively involved in molecular ... according to Kalorama Information. These include Roche Diagnostics, Hologic, Abbott ... of the 6.1 billion-dollar molecular testing market, according to ... Diagnostic s .    ... one company and only a handful of companies can ...
(Date:11/17/2015)... Paris , qui ... Paris , qui s,est tenu du ... leader de l,innovation biométrique, a inventé le premier scanner ... sur la même surface de balayage. Jusqu,ici, deux scanners ... les empreintes digitales. Désormais, un seul scanner est en ...
(Date:11/12/2015)... 2015  A golden retriever that stayed healthy despite ... has provided a new lead for treating this muscle-wasting ... Institute of MIT and Harvard and the University of ... Cell, pinpoints a protective gene that ... effects. The Boston Children,s lab of Lou Kunkel ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... 2015 --> ... "Oligonucleotide Synthesis Market by Product & Services (Primer, Probe, ... DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic Labs) ... market is expected to reach USD 1,918.6 Million by ... CAGR of 10.1% during the forecast period. ...
(Date:11/24/2015)... 24, 2015 SHPG ) announced today that ... Piper Jaffray 27 th Annual Healthcare Conference in ... at 8:30 a.m. EST (1:30 p.m. GMT). --> SHPG ... will participate in the Piper Jaffray 27 th Annual Healthcare ... Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ...
(Date:11/24/2015)... CITY , Nov. 24, 2015 /PRNewswire/ - ... "Company") announced today that the remaining 11,000 post-share ... Share Purchase Warrants (the "Series B Warrants") subject ... were exercised on November 23, 2015, which will ... Shares.  After giving effect to the issuance of ...
(Date:11/24/2015)... ... November 24, 2015 , ... InSphero AG, the leading supplier of ... has promoted Melanie Aregger to serve as Chief Operating Officer. , Having ... management team and was promoted to Head of InSphero Diagnostics in 2014. ...
Breaking Biology Technology: