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Study in Science holds promise for a new approach to drug therapy

an eleven-fold increase in the analgesic potency of morphine. Researchers believe it does this by binding to the hotspot, and blocking the G gamma beta subunit's ability to activate phopholipase C, which in turn inhibits pain signals.

"Imagine if we could identify 50 small molecules, with each one bringing about a specific set of changes in the behavior the hotspot," Smrcka said. "Taken together, this arsenal would grant us precise control over one of the most important biochemical switches in the body. This area of study is so important because of the sheer number of drugs already on the market that could be made more effective by differential targeting."


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Source:University of Rochester Medical Center


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5' RACE Anchor Primer from Invitrogen
Mouse monoclonal antibody raised against a partial recombinant FBXO11. NCBI Entrez Gene ID = FBXO11
Mouse monoclonal antibody raised against a partial recombinant ZNF155. NCBI Entrez Gene ID = ZNF155
Mouse polyclonal antibody raised against a partial recombinant LASS3. NCBI Entrez Gene ID = 204219
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